Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A0A024R0A8 | AHCYL1 | Adenosylhomocysteinase (EC 3.13.2.1) | Homo sapiens (Human) | 530 aa |
Protein Details: A0A024R0A8 (AHCYL1)
Protein Information
| Accession | A0A024R0A8 |
|---|---|
| Protein Names | Adenosylhomocysteinase (EC 3.13.2.1) |
| Gene Symbol | AHCYL1 |
| Organism | Homo sapiens (Human) |
| Length | 530 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26876311 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSMPDAMPLP11GVGEELKQAK21EIEDAEKYSF31MATVTKAPKK41QIQFADDMQE
51-10051FTKFPTKTGR61RSLSRSISQS71STDSYSSAAS81YTDSSDDEVS91PREKQQTNSK
101-150101GSSNFCVKNI111KQAEFGRREI121EIAEQDMSAL131ISLRKRAQGE141KPLAGAKIVG
151-200151CTHITAQTAV161LIETLCALGA171QCRWSACNIY181STQNEVAAAL191AEAGVAVFAW
201-250201KGESEDDFWW211CIDRCVNMDG221WQANMILDDG231GDLTHWVYKK241YPNVFKKIRG
251-300251IVEESVTGVH261RLYQLSKAGK271LCVPAMNVND281SVTKQKFDNL291YCCRESILDG
301-350301LKRTTDVMFG311GKQVVVCGYG321EVGKGCCAAL331KALGAIVYIT341EIDPICALQA
351-400351CMDGFRVVKL361NEVIRQVDVV371ITCTGNKNVV381TREHLDRMKN391SCIVCNMGHS
401-450401NTEIDVTSLR411TPELTWERVR421SQVDHVIWPD431GKRVVLLAEG441RLLNLSCSTV
451-500451PTFVLSITAT461TQALALIELY471NAPEGRYKQD481VYLLPKKMDE491YVASLHLPSF
501-530501DAHLTELTDD511QAKYLGLNKN521GPFKPNYYRY
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 106 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.54
|
|
| 151 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.80
Deep-Palm: 0.97
|
|
| 166 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.86
Deep-Palm: 0.24
|
|
| 172 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.75
Deep-Palm: 0.52
|
|
| 177 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.56
|
|
| 211 | - | - |
Unknown
(32651440)
cerebral cortex
(36430497)
|
Deep-Palm: 0.03
|
|
| 215 | - | - | - |
Deep-Palm: 0.05
|
|
| 272 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.90
Deep-Palm: 0.95
|
|
| 292 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.91
Deep-Palm: 0.59
|
|
| 293 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.94
Deep-Palm: 0.61
|
|
| 317 | - | - | - |
Deep-Palm: 0.91
|
|
| 326 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.97
|
|
| 327 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.96
|
|
| 346 | - | - | - |
Deep-Palm: 0.93
|
|
| 351 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.43
|
|
| 373 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.90
Deep-Palm: 0.82
|
|
| 392 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.73
Deep-Palm: 0.21
|
|
| 395 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.35
|
|
| 447 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.98
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
cerebral cortex
Specificity: 0.444
4/4 (100.0%)
1
frontal cortex
Specificity: 0.111
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.444
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 292 | C → W | 0.002033 | SNP | Missense Mutation | LUSC |
| 441 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 392* | C → ? | 0.002545 | SNP | Nonsense Mutation | GBM |