Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A0A024R3X4 | HSPD1 | 60 kDa heat shock protein, … | Homo sapiens (Human) | 573 aa |
Protein Details: A0A024R3X4 (HSPD1)
Protein Information
| Accession | A0A024R3X4 |
|---|---|
| Protein Names | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (Heat shock protein 60) (Mitochondrial matrix protein P1) |
| Gene Symbol | HSPD1 |
| Organism | Homo sapiens (Human) |
| Length | 573 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 22496122 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MLRLPTVFRQ11MRPVSRVLAP21HLTRAYAKDV31KFGADARALM41LQGVDLLADA
51-10051VAVTMGPKGR61TVIIEQSWGS71PKVTKDGVTV81AKSIDLKDKY91KNIGAKLVQD
101-150101VANNTNEEAG111DGTTTATVLA121RSIAKEGFEK131ISKGANPVEI141RRGVMLAVDA
151-200151VIAELKKQSK161PVTTPEEIAQ171VATISANGDK181EIGNIISDAM191KKVGRKGVIT
201-250201VKDGKTLNDE211LEIIEGMKFD221RGYISPYFIN231TSKGQKCEFQ241DAYVLLSEKK
251-300251ISSIQSIVPA261LEIANAHRKP271LVIIAEDVDG281EALSTLVLNR291LKVGLQVVAV
301-350301KAPGFGDNRK311NQLKDMAIAT321GGAVFGEEGL331TLNLEDVQPH341DLGKVGEVIV
351-400351TKDDAMLLKG361KGDKAQIEKR371IQEIIEQLDV381TTSEYEKEKL391NERLAKLSDG
401-450401VAVLKVGGTS411DVEVNEKKDR421VTDALNATRA431AVEEGIVLGG441GCALLRCIPA
451-500451LDSLTPANED461QKIGIEIIKR471TLKIPAMTIA481KNAGVEGSLI491VEKIMQSSSE
501-550501VGYDAMAGDF511VNMVEKGIID521PTKVVRTALL531DAAGVASLLT541TAEVVVTEIP
551-573551KEEKDPGMGA561MGGMGGGMGG571GMF
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 237 | - | - |
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.55
|
|
| 442 | - | - |
LNCaP
(31251020)
Unknown
(32651440)
|
GPS-Palm: 0.92
Deep-Palm: 0.98
|
|
| 447 | - | - |
LNCaP
(31251020)
Unknown
(32651440)
cerebral cortex
(36430497)
|
Deep-Palm: 0.97
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
4
cerebral cortex
Specificity: 0.364
4/4 (100.0%)
1
Jurkat T cell
Specificity: 0.091
1/1 (100.0%)
1
EC cell
Specificity: 0.091
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.364
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.091
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 362 | G → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 370 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 370 | R → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 370 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |