Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A0A087WSZ2 | ACTN3 | Actinin alpha 3 | Homo sapiens (Human) | 944 aa |
Protein Details: A0A087WSZ2 (ACTN3)
Protein Information
| Accession | A0A087WSZ2 |
|---|---|
| Protein Names | Actinin alpha 3 |
| Gene Symbol | ACTN3 |
| Organism | Homo sapiens (Human) |
| Length | 944 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29575903 31251020 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
34
LNCaP cells
Specificity: 1.000
34/46 (73.9%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MGIGLCVPPA11RCWKRLTRSS21RGQPLERPAA31TIIIGLSIVE41RSKQTQRGPV
51-10051DFSRSHSAPA61AEQECKPRIS71AARSTPAPPS81PAVPGFRTTP91CQTFTAWCNS
101-150101HLRKAGTQIE111NIEEDFRNGL121KLMLLLEVIS131GERLPRPDKG141KMRFHKIANV
151-200151NKALDFIASK161GVKLVSIGAE171EIVDGNLKMT181LGMIWTIILR191FAIQDISVEE
201-250201TSAKEGLLLW211CQRKTAPYRN221VNVQNFHTSW231KDGLALCALI241HRHRPDLIDY
251-300251AKLRKDDPIG261NLNTAFEVAE271KYLDIPKMLD281AEDIVNTPKP291DEKAIMTYVS
301-350301CFYHAFAGAE311QAETAANRIC321KVLAVNQENE331KLMEEYEKLA341SELLEWIRRT
351-400351VPWLENRVGE361PSMSAMQRKL371EDFRDYRRLH381KPPRIQEKCQ391LEINFNTLQT
401-450401KLRLSHRPAF411MPSEGKLVSD421IANAWRGLEQ431VEKGYEDWLL441SEIRRLQRLQ
451-500451HLAEKFRQKA461SLHEAWTRGK471EEMLSQRDYD481SALLQEVRAL491LRRHEAFESD
501-550501LAAHQDRVEH511IAALAQELNE521LDYHEAASVN531SRCQAICDQW541DNLGTLTQKR
551-600551RDALERMEKL561LETIDRLQLE571FARRAAPFNN581WLDGAVEDLQ591DVWLVHSVEE
601-650601TQSLLTAHDQ611FKATLPEADR621ERGAIMGIQG631EIQKICQTYG641LRPCSTNPYI
651-700651TLSPQDINTK661WDMVRKLVPS671CDQTLQEELA681RQQVNERLRR691QFAAQANAIG
701-750701PWIQAKVEEV711GRLAAGLAGS721LEEQMAGLRQ731QEQNIINYKT741NIDRLEGDHQ
751-800751LLQESLVFDN761KHTVYSMEHI771RVGWEQLLTS781IARTINEVEN791QVLTRDAKGL
801-850801SQEQLNEFRA811SFNHFDRKQN821GMMEPDDFRA831CLISMGYDLG841EVEFARIMTM
851-900851VDPNAAGVVT861FQAFIDFMTR871ETAETDTTEQ881VVASFKILAG891DKNYITPEEL
901-944901RRELPAKQAE911YCIRRMVPYK921GSGAPAGALD931YVAFSSALYG941ESDL
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 6 | Prediction (High) | - | - |
| 12 | Prediction (Medium) | - | - |
| 98 | Prediction (Low) | - | - |
| 211 | Experimental Prediction (High) | Calponin homology (CH) domain | 29575903 |
| 237 | Prediction (Medium) | - | - |
| 320 | Prediction (Low) | - | - |
| 636 | Prediction (Medium) | - | - |
| 644 | Prediction (Low) | - | - |
| 671 | Prediction (Medium) | - | - |
| 831 | Prediction (Medium) | - | - |
| 912 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 74 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 100 | R → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 100 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 176 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 325 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 372 | G → C | 0.002294 | SNP | Missense Mutation | OV |
| 402 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 436 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 494 | C → C | 0.008130 | SNP | Silent | THYM |
| 628 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 803 | R → C | 0.002545 | SNP | Missense Mutation | GBM |