Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A0A087WVQ6 | CLTC | Clathrin heavy chain | Homo sapiens (Human) | 1679 aa |
Protein Details: A0A087WVQ6 (CLTC)
Protein Information
| Accession | A0A087WVQ6 |
|---|---|
| Protein Names | Clathrin heavy chain |
| Gene Symbol | CLTC |
| Organism | Homo sapiens (Human) |
| Length | 1679 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 26876311 29575903 31251020 31382980 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAQILPIRFQ11EHLQLQNLGI21NPANIGFSTL31TMESDKFICI41REKVGEQAQV
51-10051VIIDMNDPSN61PIRRPISADS71AIMNPASKVI81ALKGIKESGK91TLQIFNIEMK
101-150101SKMKAHTMTD111DVTFWKWISL121NTVALVTDNA131VYHWSMEGES141QPVKMFDRHS
151-200151SLAGCQIINY161RTDAKQKWLL171LTGISAQQNR181VVGAMQLYSV191DRKVSQPIEG
201-250201HAASFAQFKM211EGNAEESTLF221CFAVRGQAGG231KLHIIEVGTP241PTGNQPFPKK
251-300251AVDVFFPPEA261QNDFPVAMQI271SEKHDVVFLI281TKYGYIHLYD291LETGTCIYMN
301-350301RISGETIFVT311APHEATAGII321GVNRKGQVLS331VCVEEENIIP341YITNVLQNPD
351-400351LALRMAVRNN361LAGAEELFAR371KFNALFAQGN381YSEAAKVAAN391APKGILRTPD
401-450401TIRRFQSVPA411QPGQTSPLLQ421YFGILLDQGQ431LNKYESLELC441RPVLQQGRKQ
451-500451LLEKWLKEDK461LECSEELGDL471VKSVDPTLAL481SVYLRANVPN491KVIQCFAETG
501-550501QVQKIVLYAK511KVGYTPDWIF521LLRNVMRISP531DQGQQFAQML541VQDEEPLADI
551-600551TQIVDVFMEY561NLIQQCTAFL571LDALKNNRPS581EGPLQTRLLE591MNLMHAPQVA
601-650601DAILGNQMFT611HYDRAHIAQL621CEKAGLLQRA631LEHFTDLYDI641KRAVVHTHLL
651-700651NPEWLVNYFG661SLSVEDSLEC671LRAMLSANIR681QNLQICVQVA691SKYHEQLSTQ
701-750701SLIELFESFK711SFEGLFYFLG721SIVNFSQDPD731VHFKYIQAAC741KTGQIKEVER
751-800751ICRESNCYDP761ERVKNFLKEA771KLTDQLPLII781VCDRFDFVHD791LVLYLYRNNL
801-850801QKYIEIYVQK811VNPSRLPVVI821GGLLDVDCSE831DVIKNLILVV841RGQFSTDELV
851-900851AEVEKRNRLK861LLLPWLEARI871HEGCEEPATH881NALAKIYIDS891NNNPERFLRE
901-950901NPYYDSRVVG911KYCEKRDPHL921ACVAYERGQC931DLELINVCNE941NSLFKSLSRY
951-1000951LVRRKDPELW961GSVLLESNPY971RRPLIDQVVQ981TALSETQDPE991EVSVTVKAFM
1001-10501001TADLPNELIE1011LLEKIVLDNS1021VFSEHRNLQN1031LLILTAIKAD1041RTRVMEYINR
1051-11001051LDNYDAPDIA1061NIAISNELFE1071EAFAIFRKFD1081VNTSAVQVLI1091EHIGNLDRAY
1101-11501101EFAERCNEPA1111VWSQLAKAQL1121QKGMVKEAID1131SYIKADDPSS1141YMEVVQAANT
1151-12001151SGNWEELVKY1161LQMARKKARE1171SYVETELIFA1181LAKTNRLAEL1191EEFINGPNNA
1201-12501201HIQQVGDRCY1211DEKMYDAAKL1221LYNNVSNFGR1231LASTLVHLGE1241YQAAVDGARK
1251-13001251ANSTRTWKEV1261CFACVDGKEF1271RLAQMCGLHI1281VVHADELEEL1291INYYQDRGYF
1301-13501301EELITMLEAA1311LGLERAHMGM1321FTELAILYSK1331FKPQKMREHL1341ELFWSRVNIP
1351-14001351KVLRAAEQAH1361LWAELVFLYD1371KYEEYDNAII1381TMMNHPTDAW1391KEGQFKDIIT
1401-14501401KVANVELYYR1411AIQFYLEFKP1421LLLNDLLMVL1431SPRLDHTRAV1441NYFSKVKQLP
1451-15001451LVKPYLRSVQ1461NHNNKSVNES1471LNNLFITEED1481YQALRTSIDA1491YDNFDNISLA
1501-15501501QRLEKHELIE1511FRRIAAYLFK1521GNNRWKQSVE1531LCKKDSLYKD1541AMQYASESKD
1551-16001551TELAEELLQW1561FLQEEKRECF1571GACLFTCYDL1581LRPDVVLETA1591WRHNIMDFAM
1601-16501601PYFIQVMKEY1611LTKVDKLDAS1621ESLRKEEEQA1631TETQPIVYGQ1641PQLMLTAGPS
1651-16791651VAVPPQAPFG1661YGYTAPPYGQ1671PQPGFGYSM
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 39 | CLATHRIN HEAVY CHAIN RELATED Clathrin heavy chain, N-terminal Clathrin, heavy chain, propeller repeat | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.87
|
|
| 155 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.89
Deep-Palm: 0.74
|
|
| 221 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.66
Deep-Palm: 0.87
|
|
| 296 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.16
|
|
| 332 | - | - | - |
Deep-Palm: 0.86
|
|
| 440 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.86
Deep-Palm: 0.98
|
|
| 463 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.98
|
|
| 495 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.88
Deep-Palm: 0.91
|
|
| 566 | - | - | - |
Deep-Palm: 0.48
|
|
| 621 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.82
Deep-Palm: 0.85
|
|
| 670 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.94
|
|
| 686 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.82
|
|
| 740 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.56
|
|
| 752 | - | - | - |
Deep-Palm: 0.49
|
|
| 757 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.95
|
|
| 782 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.80
Deep-Palm: 0.96
|
|
| 828 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.96
|
|
| 874 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.98
|
|
| 913 | - | - | - |
Deep-Palm: 0.89
|
|
| 922 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.90
|
|
| 930 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
Deep-Palm: 0.42
|
|
| 938 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.86
Deep-Palm: 0.91
|
|
| 1106 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
Deep-Palm: 0.66
|
|
| 1209 | - | - | - |
Deep-Palm: 0.08
|
|
| 1261 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.84
Deep-Palm: 0.76
|
|
| 1264 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.50
|
|
| 1276 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.86
|
|
| 1532 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.70
|
|
| 1569 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.80
|
|
| 1573 | - | - | - |
Deep-Palm: 0.71
|
|
| 1577 | - | - | - |
Deep-Palm: 0.94
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.364
4
cerebral cortex
Specificity: 0.267
4/4 (100.0%)
3
LNCaP
Specificity: 0.200
3/3 (100.0%)
1
U937 cell
Specificity: 0.067
1/1 (100.0%)
1
HeLa cell
Specificity: 0.067
1/1 (100.0%)
1
Jurkat T cell
Specificity: 0.067
1/1 (100.0%)
1
frontal cortex
Specificity: 0.067
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.267
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 176 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 294 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 305 | V → Cfs*6 | 0.002976 | INS | Frame Shift Ins | KIRC |
| 328 | C → Ffs*9 | 0.002747 | DEL | Frame Shift Del | LIHC |
| 354 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 655 | F → C | 0.001969 | SNP | Missense Mutation | LGG |
| 895 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 903 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 903 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 923 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1189 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1210 | M → Cfs*52 | 0.002506 | DEL | Frame Shift Del | COAD |
| 1289 | Y → C | 0.002294 | SNP | Missense Mutation | OV |
| 1544 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| ? | ? → ? | 0.001014 | SNP | Missense Mutation | BRCA |