Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A0A087WVQ6 | CLTC; hCG_1818599 | Clathrin heavy chain | Homo sapiens (Human) | 1679 aa |
Protein Details: A0A087WVQ6 (CLTC)
Protein Information
| Accession | A0A087WVQ6 |
|---|---|
| Protein Names | Clathrin heavy chain |
| Gene Symbol | CLTC; hCG_1818599 |
| Organism | Homo sapiens (Human) |
| Length | 1679 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 21076176 26876311 29575903 31251020 31382980 32944167 36430497 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.621
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
36
LNCaP cells
Specificity: 0.621
36/46 (78.3%)
11
Jurkat T cells
Specificity: 0.190
11/25 (44.0%)
4
PC3 cells
Specificity: 0.069
4/4 (100.0%)
4
Cerebral cortex
Specificity: 0.069
4/4 (100.0%)
1
U937 cells
Specificity: 0.017
1/1 (100.0%)
1
HeLa cells
Specificity: 0.017
1/1 (100.0%)
1
Prefrontal cortex
Specificity: 0.017
1/1 (100.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MAQILPIRFQ11EHLQLQNLGI21NPANIGFSTL31TMESDKFICI41REKVGEQAQV
51-10051VIIDMNDPSN61PIRRPISADS71AIMNPASKVI81ALKGIKESGK91TLQIFNIEMK
101-150101SKMKAHTMTD111DVTFWKWISL121NTVALVTDNA131VYHWSMEGES141QPVKMFDRHS
151-200151SLAGCQIINY161RTDAKQKWLL171LTGISAQQNR181VVGAMQLYSV191DRKVSQPIEG
201-250201HAASFAQFKM211EGNAEESTLF221CFAVRGQAGG231KLHIIEVGTP241PTGNQPFPKK
251-300251AVDVFFPPEA261QNDFPVAMQI271SEKHDVVFLI281TKYGYIHLYD291LETGTCIYMN
301-350301RISGETIFVT311APHEATAGII321GVNRKGQVLS331VCVEEENIIP341YITNVLQNPD
351-400351LALRMAVRNN361LAGAEELFAR371KFNALFAQGN381YSEAAKVAAN391APKGILRTPD
401-450401TIRRFQSVPA411QPGQTSPLLQ421YFGILLDQGQ431LNKYESLELC441RPVLQQGRKQ
451-500451LLEKWLKEDK461LECSEELGDL471VKSVDPTLAL481SVYLRANVPN491KVIQCFAETG
501-550501QVQKIVLYAK511KVGYTPDWIF521LLRNVMRISP531DQGQQFAQML541VQDEEPLADI
551-600551TQIVDVFMEY561NLIQQCTAFL571LDALKNNRPS581EGPLQTRLLE591MNLMHAPQVA
601-650601DAILGNQMFT611HYDRAHIAQL621CEKAGLLQRA631LEHFTDLYDI641KRAVVHTHLL
651-700651NPEWLVNYFG661SLSVEDSLEC671LRAMLSANIR681QNLQICVQVA691SKYHEQLSTQ
701-750701SLIELFESFK711SFEGLFYFLG721SIVNFSQDPD731VHFKYIQAAC741KTGQIKEVER
751-800751ICRESNCYDP761ERVKNFLKEA771KLTDQLPLII781VCDRFDFVHD791LVLYLYRNNL
801-850801QKYIEIYVQK811VNPSRLPVVI821GGLLDVDCSE831DVIKNLILVV841RGQFSTDELV
851-900851AEVEKRNRLK861LLLPWLEARI871HEGCEEPATH881NALAKIYIDS891NNNPERFLRE
901-950901NPYYDSRVVG911KYCEKRDPHL921ACVAYERGQC931DLELINVCNE941NSLFKSLSRY
951-1000951LVRRKDPELW961GSVLLESNPY971RRPLIDQVVQ981TALSETQDPE991EVSVTVKAFM
1001-10501001TADLPNELIE1011LLEKIVLDNS1021VFSEHRNLQN1031LLILTAIKAD1041RTRVMEYINR
1051-11001051LDNYDAPDIA1061NIAISNELFE1071EAFAIFRKFD1081VNTSAVQVLI1091EHIGNLDRAY
1101-11501101EFAERCNEPA1111VWSQLAKAQL1121QKGMVKEAID1131SYIKADDPSS1141YMEVVQAANT
1151-12001151SGNWEELVKY1161LQMARKKARE1171SYVETELIFA1181LAKTNRLAEL1191EEFINGPNNA
1201-12501201HIQQVGDRCY1211DEKMYDAAKL1221LYNNVSNFGR1231LASTLVHLGE1241YQAAVDGARK
1251-13001251ANSTRTWKEV1261CFACVDGKEF1271RLAQMCGLHI1281VVHADELEEL1291INYYQDRGYF
1301-13501301EELITMLEAA1311LGLERAHMGM1321FTELAILYSK1331FKPQKMREHL1341ELFWSRVNIP
1351-14001351KVLRAAEQAH1361LWAELVFLYD1371KYEEYDNAII1381TMMNHPTDAW1391KEGQFKDIIT
1401-14501401KVANVELYYR1411AIQFYLEFKP1421LLLNDLLMVL1431SPRLDHTRAV1441NYFSKVKQLP
1451-15001451LVKPYLRSVQ1461NHNNKSVNES1471LNNLFITEED1481YQALRTSIDA1491YDNFDNISLA
1501-15501501QRLEKHELIE1511FRRIAAYLFK1521GNNRWKQSVE1531LCKKDSLYKD1541AMQYASESKD
1551-16001551TELAEELLQW1561FLQEEKRECF1571GACLFTCYDL1581LRPDVVLETA1591WRHNIMDFAM
1601-16501601PYFIQVMKEY1611LTKVDKLDAS1621ESLRKEEEQA1631TETQPIVYGQ1641PQLMLTAGPS
1651-16791651VAVPPQAPFG1661YGYTAPPYGQ1671PQPGFGYSM
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 39 | Prediction (Low) | - | - |
| 155 | Prediction (Medium) | - | - |
| 221 | Prediction (Low) | - | - |
| 296 | Prediction (Low) | - | - |
| 440 | Prediction (Medium) | - | - |
| 463 | Prediction (Low) | - | - |
| 495 | Prediction (Medium) | - | - |
| 621 | Prediction (Medium) | - | - |
| 670 | Prediction (Medium) | - | - |
| 686 | Prediction (Low) | - | - |
| 740 | Prediction (Medium) | - | - |
| 757 | Prediction (Low) | - | - |
| 782 | Prediction (Medium) | - | - |
| 938 | Prediction (Medium) | - | - |
| 1261 | Prediction (Medium) | - | - |
| 1264 | Prediction (Low) | - | - |
| 1276 | Prediction (Low) | - | - |
| 1532 | Prediction (Medium) | - | - |
| 1569 | Prediction (Low) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 176 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 294 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 305 | V → Cfs*6 | 0.002976 | INS | Frame Shift Ins | KIRC |
| 328 | C → Ffs*9 | 0.002747 | DEL | Frame Shift Del | LIHC |
| 354 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 655 | F → C | 0.001969 | SNP | Missense Mutation | LGG |
| 895 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 903 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 903 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 923 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1189 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1210 | M → Cfs*52 | 0.002506 | DEL | Frame Shift Del | COAD |
| 1289 | Y → C | 0.002294 | SNP | Missense Mutation | OV |
| 1544 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| ? | ? → ? | 0.001014 | SNP | Missense Mutation | BRCA |