Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A0A0A0MSC1 | ADCY3 | Adenylate cyclase type 3 (EC … | Homo sapiens (Human) | 1145 aa |
Protein Details: A0A0A0MSC1 (ADCY3)
Protein Information
| Accession | A0A0A0MSC1 |
|---|---|
| Protein Names | Adenylate cyclase type 3 (EC 4.6.1.1) |
| Gene Symbol | ADCY3 |
| Organism | Homo sapiens (Human) |
| Length | 1145 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19801377 31251020 31382980 32944167 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.583
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
7
LNCaP cells
Specificity: 0.583
7/46 (15.2%)
4
PC3 cells
Specificity: 0.333
4/4 (100.0%)
1
U937 cells
Specificity: 0.083
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MPRNQGFSEP11EYSAEYSAEY21SVSLPSDPDR31GVGRTHEISV41RNSGSCLCLP
51-10051RFMRLTFVPE61SLENLYQTYF71KRQRHETLLV81LVVFAALFDC91YVVVMCAVVF
101-150101SSDKLASLAV111AGIGLVLDII121LFVLCKKGLL131PDRVTRRVLP141YVLWLLITAQ
151-200151IFSYLGLNFA161RAHAASDTVG171WQVFFVFSFF181ITLPLSLSPI191VIISVVSCVV
201-250201HTLVLGVTVA211QQQQEELKGM221QLLREILANV231FLYLCAIAVG241IMSYYMADRK
251-300251HRKAFLEARQ261SLEVKMNLEE271QSQQQENLML281SILPKHVADE291MLKDMKKDES
301-350301QKDQQQFNTM311YMYRHENVSI321LFADIVGFTQ331LSSACSAQEL341VKLLNELFAR
351-400351FDKLAAKYHQ361LRIKILGDCY371YCICGLPDYR381EDHAVCSILM391GLAMVEAISY
401-450401VREKTKTGVD411MRVGVHTGTV421LGGVLGQKRW431QYDVWSTDVT441VANKMEAGGI
451-500451PGRVHISQST461MDCLKGEFDV471EPGDGGSRCD481YLEEKGIETY491LIIASKPEVK
501-550501KTATQNGLNG511SALPNGAPAS521SKSSSPALIE531TKEPNGSAHS541SGSTSEKPEE
551-600551QDAQADNPSF561PNPRRRLRLQ571DLADRVVDAS581EDEHELNQLL591NEALLERESA
601-650601QVVKKRNTFL611LSMRFMDPEM621ETRYSVEKEK631QSGAAFSCSC641VVLLCTALVE
651-700651ILIDPWLMTN661YVTFMVGEIL671LLILTICSLA681AIFPRAFPKK691LVAFSTWIDR
701-750701TRWARNTWAM711LAIFILVMAN721VVDMLSCLQY731YTGPSNATAG741METEGSCLEN
751-800751PKYYNYVAVL761SLIATIMLVQ771VSHMVKLTLM781LLVAGAVATI791NLYAWRPVFD
801-850801EYDHKRFREH811DLPMVALEQM821QGFNPGLNGT831DSRLPLVPSK841YSMTVMVFLM
851-900851MLSFYYFSRH861VEKLARTLFL871WKIEVHDQKE881RVYEMRRWNE891ALVTNMLPEH
901-950901VARHFLGSKK911RDEELYSQTY921DEIGVMFASL931PNFADFYTEE941SINNGGIECL
951-1000951RFLNEIISDF961DSLLDNPKFR971VITKIKTIGS981TYMAASGVTP991DVNTNGFASS
1001-10501001NKEDKSERER1011WQHLADLADF1021ALAMKDTLTN1031INNQSFNNFM1041LRIGMNKGGV
1051-11001051LAGVIGARKP1061HYDIWGNTVN1071VASRMESTGV1081MGNIQVVEET1091QVILREYGFR
1101-11451101FVRRGPIFVK1111GKGELLTFFL1121KGRDKLATFP1131NGPSVTLPHQ1141VVDNS
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 46 | Experimental Prediction (High) | - | 19801377 |
| 48 | Experimental Prediction (High) | - | 19801377 |
| 90 | Prediction (Low) | - | - |
| 125 | Prediction (High) | - | - |
| 198 | Prediction (Low) | - | - |
| 335 | Prediction (Medium) | - | - |
| 369 | Prediction (Low) | - | - |
| 372 | Prediction (Low) | - | - |
| 374 | Prediction (Low) | - | - |
| 638 | Prediction (Low) | - | - |
| 677 | Prediction (Medium) | - | - |
| 949 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 48 | C → S | 0.002747 | SNP | Missense Mutation | LIHC |
| 129 | L → Cfs*19 | 0.001887 | DEL | Frame Shift Del | UCEC |
| 415 | V → Cfs*27 | 0.002288 | DEL | Frame Shift Del | STAD |
| 415 | V → Cfs*27 | 0.002506 | DEL | Frame Shift Del | COAD |
| 858 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 880 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 880 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1041 | R → C | 0.002288 | SNP | Missense Mutation | STAD |