Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A0A0U1RRM8 | FERMT2 | FERM domain containing kindlin 2 | Homo sapiens (Human) | 545 aa |
Protein Details: A0A0U1RRM8 (FERMT2)
Protein Information
| Accession | A0A0U1RRM8 |
|---|---|
| Protein Names | FERM domain containing kindlin 2 |
| Gene Symbol | FERMT2 |
| Organism | Homo sapiens (Human) |
| Length | 545 aa |
| Isoforms | No isoforms |
| Related PMIDs | 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MALELEGPLI11TPGSGTDVLY21IGPLKGSIYS31SPGLYSKTMT41PTYDAHDGSP
51-10051LSPTSAWFGD61SALSEGNPGI71LAVSQPITSP81EILAKMFKPQ91ALLDKAKINQ
101-150101GWLDSSRSLM111EQDVKENEAL121LLRFKYYSFF131DLNPKYDAIR141INQLYEQAKW
151-200151AILLEEIECT161EEEMMMFAAL171QYHINKLSIM181TSENHLNNSD191KEVDEVDAAL
201-250201SDLEITLEGG211KTSTILGDIT221SIPELADYIK231VFKPKKLTLK241GYKQYWCTFK
251-300251DTSISCYKSK261EESSGTPAHQ271MNLRGCEVTP281DVNISGQKFN291IKLLIPVAEG
301-350301MNEIWLRCDN311EKQYAHWMAA321CRLASKGKTM331ADSSYNLEVQ341NILSFLKMQH
351-400351LNPDPQLIPE361QITTDITPEC371LVSPRYLKKY381KNKQEKGCKK391HMPGYIRDLI
401-450401TARILEAHQN411VAQMSLIEAK421MRFIQAWQSL431PEFGITHFIA441RFQGGKKEEL
451-500451IGIAYNRLIR461MDASTGDAIK471TWRFSNMKQW481NVNWEIKMVT491VEFADEVRLS
501-545501FICTEVDCKV511VHEFIGGYIF521LSTRAKDQNE531SLDEEMFYKL541TSGWV
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 159 | - | - | - |
Deep-Palm: 0.23
|
|
| 247 | - | - | - |
Deep-Palm: 0.50
|
|
| 256 | - | - | - |
Deep-Palm: 0.05
|
|
| 276 | SWISSPALM DBPTM CYSMODDB | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.55
|
| 308 | - | - | - |
Deep-Palm: 0.11
|
|
| 321 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.28
|
|
| 370 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.86
|
|
| 388 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.64
|
|
| 503 | - | - | - |
Deep-Palm: 0.32
|
|
| 508 | - | - | - |
Deep-Palm: 0.21
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
4
PC3
Specificity: 0.400
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.400
4/4 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
Cerebral Cortex (Mass)
Specificity: 0.200
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 115 | F → C | 0.007299 | SNP | Missense Mutation | READ |
| 397 | C → C | 0.006993 | SNP | Silent | LAML |
| 426 | C → Mfs*2 | 0.002545 | INS | Frame Shift Ins | GBM |
| 439 | F → C | 0.002506 | SNP | Missense Mutation | COAD |
| 525 | R → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 558 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 608 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 679 | W → C | 0.001764 | SNP | Missense Mutation | LUAD |