Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A0A140VKH4 | CAPN5 | Calpain-5 | Homo sapiens (Human) | 640 aa |
Protein Details: A0A140VKH4 (CAPN5)
Protein Information
| Accession | A0A140VKH4 |
|---|---|
| Protein Names | Calpain-5 |
| Gene Symbol | CAPN5 |
| Organism | Homo sapiens (Human) |
| Length | 640 aa |
| Isoforms | No isoforms |
| Related PMIDs | 22496122 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MFSCVKPYED11QNYSALRRDC21RRRKVLFEDP31LFPATDDSLY41YKGTPGPAVR
51-10051WKRPKGICED61PRLFVDGISS71HDLHQGQVGN81CWFVAACSSL91ASRESLWQKV
101-150101IPDWKEQEWD111PEKPNAYAGI121FHFHFWRFGE131WVDVVIDDRL141PTVNNQLIYC
151-200151HSNSRNEFWC161ALVEKAYAKL171AGCYQALDGG181NTADALVDFT191GGVSEPIDLT
201-250201EGDFANDETK211RNQLFERMLK221VHSRGGLISA231SIKAVTAADM241EARLACGLVK
251-300251GHAYAVTDVR261KVRLGHGLLA271FFKSEKLDMI281RLRNPWGERE291WNGPWSDTSE
301-350301EWQKVSKSER311EKMGVTVQDD321GEFWMTFEDV331CRYFTDIIKC341RVINTSHLSI
351-400351HKTWEEARLH361GAWTLHEDPR371QNRGGGCINH381KDTFFQNPQY391IFEVKKPEDE
401-450401VLICIQQRPK411RSTRREGKGE421NLAIGFDIYK431VEENRQYRMH441SLQHKAASSI
451-500451YINSRSVFLR461TDQPEGRYVI471IPTTFEPGHT481GEFLLRVFTD491VPSNCRELRL
501-550501DEPPHTCWSS511LCGYPQLVTQ521VHVLGAAGLK531DSPTGANSYV541IIKCEGDKVR
551-600551SAVQKGTSTP561EYNVKGIFYR571KKLSQPITVQ581VWNHRVLKDE591FLGQVHLKAD
601-640601PDNLQALHTL611HLRDRNSRQP621SNLPGTVAVH631ILSSTSLMAV
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 4 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.01
|
|
| 20 | Papain-like cysteine peptidase superfamily | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.80
|
|
| 58 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.86
|
|
| 81 | - | - | - |
Deep-Palm: 0.19
|
|
| 87 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.22
|
|
| 150 | - | - |
LNCaP
(31251020)
cerebral cortex
(36430497)
|
Deep-Palm: 0.25
|
|
| 160 | - | - |
LNCaP
(31251020)
cerebral cortex
(36430497)
|
Deep-Palm: 0.30
|
|
| 173 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.95
|
|
| 246 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.92
|
|
| 331 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.02
|
|
| 340 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.06
|
|
| 377 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.10
|
|
| 404 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.92
Deep-Palm: 0.88
|
|
| 495 | - | - |
LNCaP
(31251020)
cerebral cortex
(36430497)
|
GPS-Palm: 0.89
Deep-Palm: 0.80
|
|
| 507 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.54
|
|
| 512 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.80
|
|
| 544 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.83
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
cerebral cortex
Specificity: 0.364
4/4 (100.0%)
1
EC cell
Specificity: 0.091
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
4
Cerebral Cortex (Mass)
Specificity: 0.364
4/4 (100.0%)
2
LNCaP cells (Mass)
Specificity: 0.182
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 254 | Y → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 263 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 267 | G → C | 0.002545 | SNP | Missense Mutation | GBM |
| 283 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 286 | W → C | 0.003460 | SNP | Missense Mutation | CESC |
| 373 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 419 | G → C | 0.002506 | SNP | Missense Mutation | COAD |
| 467 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 499 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 570 | R → C | 0.005618 | SNP | Missense Mutation | PAAD |