Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A0A1B0GWB6 | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase (EC 3.1.4.11) | Homo sapiens (Human) | 1072 aa |
Protein Details: A0A1B0GWB6 (PLCB1)
Protein Information
| Accession | A0A1B0GWB6 |
|---|---|
| Protein Names | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase (EC 3.1.4.11) |
| Gene Symbol | PLCB1 |
| Organism | Homo sapiens (Human) |
| Length | 1072 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26876311 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
1
Prefrontal cortex
Specificity: 1.000
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MITVVYGPDL11VNISHLNLVA21FQEEVAKEWT31NEVFSLATNL41LAQNMSRDAF
51-10051LEKAYTKLKL61QVTPEGRIPL71KNIYRLFSAD81RKRVETALEA91CSLPSSRNDS
101-150101IPQEDFTPEV111YRVFLNNLCP121RPEIDNIFSE131FGAKSKPYLT141VDQMMDFINL
151-200151KQRDPRLNEI161LYPPLKQEQV171QVLIEKYEPN181NSLARKGQIS191VDGFMRYLSG
201-250201EENGVVSPEK211LDLNEDMSQP221LSHYFINSSH231NTYLTAGQLA241GNSSVEMYRQ
251-300251VLLSGCRCVE261LDCWKGRTAE271EEPVITHGFT281MTTEISFKEV291IEAIAECAFK
301-350301TSPFPILLSF311ENHVDSPKQQ321AKMAEYCRLI331FGDALLMEPL341EKYPLESGVP
351-400351LPSPMDLMYK361ILVKNKKKSH371KSSEGSGKKK381LSEQASNTYS391DSSSMFEPSS
401-450401PGAGEADTES411DDDDDDDDCK421KSSMDEGTAG431SEAMATEEMS441NLVNYIQPVK
451-500451FESFEISKKR461NKSFEMSSFV471ETKGLEQLTK481SPVEFVEYNK491MQLSRIYPKG
501-550501TRVDSSNYMP511QLFWNAGCQM521VALNFQTMDL531AMQINMGMYE541YNGKSGYRLK
551-600551PEFMRRPDKH561FDPFTEGIVD571GIVANTLSVK581IISGQFLSDK591KVGTYVEVDM
601-650601FGLPVDTRRK611AFKTKTSQGN621AVNPVWEEEP631IVFKKVVLPT641LACLRIAVYE
651-700651EGGKFIGHRI661LPVQAIRPGY671HYICLRNERN681QPLTLPAVFV691YIEVKDYVPD
701-750701TYADVIEALS711NPIRYVNLME721QRAKQLAALT731LEDEEEVKKE741ADPGETPSEA
751-800751PSEARTTPAE761NGVNHTTTLT771PKPPSQALHS781QPAPGSVKAP791AKTEDLIQSV
801-850801LTEVEAQTIE811ELKQQKSFVK821LQKKHYKEMK831DLVKRHHKKT841TDLIKEHTTK
851-900851YNEIQNDYLR861RRAALEKSAK871KDSKKKSEPS881SPDHGSSTIE891QDLAALDAEM
901-950901TQKLIDLKDK911QQQQLLNLRQ921EQYYSEKYQK931REHIKLLIQK941LTDVAEECQN
951-1000951NQLKKLKEIC961EKEKKELKKK971MDKKRQEKIT981EAKSKDKSQM991EEEKTEMIRS
1001-10501001YIQEVVQYIK1011RLEEAQSKRQ1021EKLVEKHKEI1031RQQILDEKPK1041GEGSSSFLSE
1051-10721051TCHEDPSVSP1061NFTPPNPQAL1071KW
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 91 | Prediction (High) | - | - |
| 119 | Prediction (Low) | - | - |
| 256 | Prediction (Medium) | - | - |
| 297 | Prediction (Medium) | - | - |
| 327 | Prediction (Medium) | - | - |
| 643 | Prediction (High) | - | - |
| 674 | Prediction (Medium) | - | - |
| 948 | Prediction (Medium) | - | - |
| 960 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 101 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 130 | W → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 168 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 176 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 350 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 350 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 398 | C → S | 0.001764 | SNP | Missense Mutation | LUAD |
| 546 | Y → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 565 | F → C | 0.007299 | SNP | Missense Mutation | READ |
| 603 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 647 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 648 | Y → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 760 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 1029 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |