Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A0A1B0GWB6 | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase (EC 3.1.4.11) | Homo sapiens (Human) | 1072 aa |
Protein Details: A0A1B0GWB6 (PLCB1)
Protein Information
| Accession | A0A1B0GWB6 |
|---|---|
| Protein Names | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase (EC 3.1.4.11) |
| Gene Symbol | PLCB1 |
| Organism | Homo sapiens (Human) |
| Length | 1072 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26876311 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MITVVYGPDL11VNISHLNLVA21FQEEVAKEWT31NEVFSLATNL41LAQNMSRDAF
51-10051LEKAYTKLKL61QVTPEGRIPL71KNIYRLFSAD81RKRVETALEA91CSLPSSRNDS
101-150101IPQEDFTPEV111YRVFLNNLCP121RPEIDNIFSE131FGAKSKPYLT141VDQMMDFINL
151-200151KQRDPRLNEI161LYPPLKQEQV171QVLIEKYEPN181NSLARKGQIS191VDGFMRYLSG
201-250201EENGVVSPEK211LDLNEDMSQP221LSHYFINSSH231NTYLTAGQLA241GNSSVEMYRQ
251-300251VLLSGCRCVE261LDCWKGRTAE271EEPVITHGFT281MTTEISFKEV291IEAIAECAFK
301-350301TSPFPILLSF311ENHVDSPKQQ321AKMAEYCRLI331FGDALLMEPL341EKYPLESGVP
351-400351LPSPMDLMYK361ILVKNKKKSH371KSSEGSGKKK381LSEQASNTYS391DSSSMFEPSS
401-450401PGAGEADTES411DDDDDDDDCK421KSSMDEGTAG431SEAMATEEMS441NLVNYIQPVK
451-500451FESFEISKKR461NKSFEMSSFV471ETKGLEQLTK481SPVEFVEYNK491MQLSRIYPKG
501-550501TRVDSSNYMP511QLFWNAGCQM521VALNFQTMDL531AMQINMGMYE541YNGKSGYRLK
551-600551PEFMRRPDKH561FDPFTEGIVD571GIVANTLSVK581IISGQFLSDK591KVGTYVEVDM
601-650601FGLPVDTRRK611AFKTKTSQGN621AVNPVWEEEP631IVFKKVVLPT641LACLRIAVYE
651-700651EGGKFIGHRI661LPVQAIRPGY671HYICLRNERN681QPLTLPAVFV691YIEVKDYVPD
701-750701TYADVIEALS711NPIRYVNLME721QRAKQLAALT731LEDEEEVKKE741ADPGETPSEA
751-800751PSEARTTPAE761NGVNHTTTLT771PKPPSQALHS781QPAPGSVKAP791AKTEDLIQSV
801-850801LTEVEAQTIE811ELKQQKSFVK821LQKKHYKEMK831DLVKRHHKKT841TDLIKEHTTK
851-900851YNEIQNDYLR861RRAALEKSAK871KDSKKKSEPS881SPDHGSSTIE891QDLAALDAEM
901-950901TQKLIDLKDK911QQQQLLNLRQ921EQYYSEKYQK931REHIKLLIQK941LTDVAEECQN
951-1000951NQLKKLKEIC961EKEKKELKKK971MDKKRQEKIT981EAKSKDKSQM991EEEKTEMIRS
1001-10501001YIQEVVQYIK1011RLEEAQSKRQ1021EKLVEKHKEI1031RQQILDEKPK1041GEGSSSFLSE
1051-10721051TCHEDPSVSP1061NFTPPNPQAL1071KW
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 91 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.93
Deep-Palm: 0.97
|
|
| 119 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.68
Deep-Palm: 0.76
|
|
| 256 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.64
|
|
| 258 | - | - | - |
Deep-Palm: 0.78
|
|
| 263 | - | - | - |
Deep-Palm: 0.72
|
|
| 297 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.86
Deep-Palm: 0.73
|
|
| 327 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.81
|
|
| 419 | - | - | - |
Deep-Palm: 0.33
|
|
| 518 | - | - | - |
Deep-Palm: 0.09
|
|
| 643 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.94
Deep-Palm: 0.92
|
|
| 674 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.85
|
|
| 948 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.92
|
|
| 960 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.96
|
|
| 1052 | - | - | - |
Deep-Palm: 0.61
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
cerebral cortex
Specificity: 0.571
4/4 (100.0%)
1
frontal cortex
Specificity: 0.143
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
Cerebral Cortex (Mass)
Specificity: 0.286
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 101 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 130 | W → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 168 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 176 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 350 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 350 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 398 | C → S | 0.001764 | SNP | Missense Mutation | LUAD |
| 546 | Y → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 565 | F → C | 0.007299 | SNP | Missense Mutation | READ |
| 603 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 647 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 648 | Y → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 760 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 1029 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |