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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
A0A2R8Y4R4 ATP2B2 ATPase plasma membrane Ca2+ transporting … Homo sapiens (Human) 996 aa

Protein Details: A0A2R8Y4R4 (ATP2B2)

Protein Information
AccessionA0A2R8Y4R4
Protein NamesATPase plasma membrane Ca2+ transporting 2
Gene SymbolATP2B2
OrganismHomo sapiens (Human)
Length996 aa
IsoformsNo isoforms
Related PMIDs 26876311 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesNo database sources
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501DESSLTGESD11QVRKSVDKDP21MLLSGTHVME31GSGRMLVTAV41GVNSQTGIIF
51-10051TLLGAGGEEE61EKKDKKAADG71AAASNAADSA81NASLVNGKMQ91DGNVDASQSK
101-150101AKQQDGAAAM111EMQPLKSAEG121GDADDRKKAS131MHKKEKSVLQ141GKLTKLAVQI
151-200151GKAGLVMSAI161TVIILVLYFT171VDTFVVNKKP181WLPECTPVYV191QYFVKFFIIG
201-250201VTVLVVAVPE211GLPLAVTISL221AYSVKKMMKD231NNLVRHLDAC241ETMGNATAIC
251-300251SDKTGTLTTN261RMTVVQAYVG271DVHYKEIPDP281SSINTKTMEL291LINAIAINSA
301-350301YTTKILPPEK311EGALPRQVGN321KTECGLLGFV331LDLKQDYEPV341RSQMPEEKLY
351-400351KVYTFNSVRK361SMSTVIKLPD371ESFRMYSKGA381SEIVLKKCCK391ILNGAGEPRV
401-450401FRPRDRDEMV411KKVIEPMACD421GLRTICVAYR431DFPSSPEPDW441DNENDILNEL
451-500451TCICVVGIED461PVRPEVPEAI471RKCQRAGITV481RMVTGDNINT491ARAIAIKCGI
501-550501IHPGEDFLCL511EGKEFNRRIR521NEKGEIEQER531IDKIWPKLRV541LARSSPTDKH
551-600551TLVKGIIDST561HTEQRQVVAV571TGDGTNDGPA581LKKADVGFAM591GIAGTDVAKE
601-650601ASDIILTDDN611FSSIVKAVMW621GRNVYDSISK631FLQFQLTVNV641VAVIVAFTGA
651-700651CITQDSPLKA661VQMLWVNLIM671DTFASLALAT681EPPTETLLLR691KPYGRNKPLI
701-750701SRTMMKNILG711HAVYQLALIF721TLLFVGEKMF731QIDSGRNAPL741HSPPSEHYTI
751-800751IFNTFVMMQL761FNEINARKIH771GERNVFDGIF781RNPIFCTIVL791GTFAIQIVIV
801-850801QFGGKPFSCS811PLQLDQWMWC821IFIGLGELVW831GQVIATIPTS841RLKFLKEAGR
851-900851LTQKEEIPEE861ELNEDVEEID871HAERELRRGQ881ILWFRGLNRI891QTQIRVVKAF
901-950901RSSLYEGLEK911PESRTSIHNF921MAHPEFRIED931SQPHIPLIDD941TDLEEDAALK
951-996951QNSSPPSSLN961KNNSAIDSGI971NLTTDTSKSA981TSSSPGSPIH991SLETSL
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
185 - - -
Deep-Palm: 0.23
240 - -
cerebral cortex (36430497)
Deep-Palm: 0.76
250 - -
cerebral cortex (36430497)
GPS-Palm: 0.80
Deep-Palm: 0.93
324 - - -
GPS-Palm: 0.86
Deep-Palm: 0.97
388 - - -
GPS-Palm: 0.75
Deep-Palm: 0.85
389 - - -
GPS-Palm: 0.81
Deep-Palm: 0.86
419 - - -
GPS-Palm: 0.87
Deep-Palm: 0.57
426 - - -
GPS-Palm: 0.73
Deep-Palm: 0.37
452 - - -
Deep-Palm: 0.24
454 - - -
Deep-Palm: 0.29
473 - - -
GPS-Palm: 0.85
Deep-Palm: 0.94
498 - - -
GPS-Palm: 0.82
Deep-Palm: 0.83
509 - - -
GPS-Palm: 0.89
Deep-Palm: 0.87
651 - - -
GPS-Palm: 0.86
Deep-Palm: 0.92
786 - - -
Deep-Palm: 0.38
809 - - -
GPS-Palm: 0.88
Deep-Palm: 0.08
820 - - -
Deep-Palm: 0.10
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
frontal cortex
Specificity: 0.333
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
Cerebral Cortex (Mass)
Specificity: 0.667
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
32 R → C 0.002141 SNP Missense Mutation SKCM
32 R → C 0.001887 SNP Missense Mutation UCEC
59 R → C 0.002294 SNP Missense Mutation OV
86 F → C 0.007299 SNP Missense Mutation READ
151 W → C 0.001887 SNP Missense Mutation UCEC
185 R → C 0.001764 SNP Missense Mutation LUAD
249 R → C 0.002288 SNP Missense Mutation STAD
249 R → C 0.002506 SNP Missense Mutation COAD
432 C → S 0.006944 SNP Missense Mutation TGCT
491 G → C 0.002033 SNP Missense Mutation LUSC
497 C → S 0.001764 SNP Missense Mutation LUAD
559 G → C 0.002288 SNP Missense Mutation STAD
588 R → C 0.001887 SNP Missense Mutation UCEC
597 Y → C 0.001887 SNP Missense Mutation UCEC
606 R → C 0.001969 SNP Missense Mutation HNSC
606 R → C 0.002020 SNP Missense Mutation PRAD
606 R → C 0.001887 SNP Missense Mutation UCEC
621 R → C 0.001764 SNP Missense Mutation LUAD
621 R → C 0.002141 SNP Missense Mutation SKCM
651 R → C 0.001887 SNP Missense Mutation UCEC
666 C → C 0.001887 SNP Silent UCEC
673 C → C 0.001887 SNP Silent UCEC
677 R → C 0.005435 SNP Missense Mutation ESCA
699 C → C 0.001887 SNP Silent UCEC
869 R → C 0.001887 SNP Missense Mutation UCEC
1014 R → C 0.001887 SNP Missense Mutation UCEC
1020 R → C 0.001887 SNP Missense Mutation UCEC
1055 S → C 0.002747 SNP Missense Mutation LIHC
1067 C → C 0.003460 SNP Silent CESC
1142 R → C 0.002141 SNP Missense Mutation SKCM
1178 S → C 0.002294 SNP Missense Mutation OV
1211 S → C 0.001764 SNP Missense Mutation LUAD