Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A0A2R8Y7L2 | HSD17B4 | 17-beta-hydroxysteroid dehydrogenase 4 (D-bifunctional protein) … | Homo sapiens (Human) | 589 aa |
Protein Details: A0A2R8Y7L2 (HSD17B4)
Protein Information
| Accession | A0A2R8Y7L2 |
|---|---|
| Protein Names | 17-beta-hydroxysteroid dehydrogenase 4 (D-bifunctional protein) (Multifunctional protein 2) |
| Gene Symbol | HSD17B4 |
| Organism | Homo sapiens (Human) |
| Length | 589 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MTSSASGIYG11NFGQANYSAA21KLGLLGLANS31LAIEGRKSNI41HCNTIAPNAG
51-10051SRMTQTVMPE61DLVEALKPEY71VAPLVLWLCH81ESCEENGGLF91EVGAGWIGKL
101-150101RWERTLGAIV111RQKNHPMTPE121AVKANWKKIC131DFENASKPQS141IQESTGSIIE
151-200151VLSKIDSEGG161VSANHTSRAT171STATSGFAGA181IGQKLPPFSY191AYTELEAIMY
201-250201ALGVGASIKD211PKDLKFIYEG221SSDFSCLPTF231GVIIGQKSMM241GGGLAEIPGL
251-300251SINFAKVLHG261EQYLELYKPL271PRAGKLKCEA281VVADVLDKGS291GVVIIMDVYS
301-350301YSEKELICHN311QFSLFLVGSG321GFGGKRTSDK331VKVAVAIPNR341PPDAVLTDTT
351-400351SLNQAALYRL361SGDWNPLHID371PNFASLAGFD381KPILHGLCTF391GFSARRVLQQ
401-450401FADNDVSRFK411AIKARFAKPV421YPGQTLQTEM431WKEGNRIHFQ441TKVQETGDIV
451-500451ISNAYVDLAP461TSGTSAKTPS471EGGKLQSTFV481FEEIGRRLKD491IGPEVVKKVN
501-550501AVFEWHITKG511GNIGAKWTID521LKSGSGKVYQ531GPAKGAADTT541IILSDEDFME
551-589551VVLGKLDPQK561AFFSGRLKAR571GNIMLSQKLQ581MILKDYAKL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 42 | Peroxisomal Beta-Oxidation Enzymes | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.95
|
|
| 79 | - | - | - |
Deep-Palm: 0.98
|
|
| 83 | - | - | - |
Deep-Palm: 0.95
|
|
| 130 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.77
Deep-Palm: 0.58
|
|
| 226 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.70
|
|
| 278 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.81
Deep-Palm: 0.98
|
|
| 308 | - | - | - |
Deep-Palm: 0.31
|
|
| 388 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.93
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
Cerebral Cortex (Mass)
Specificity: 1.000
3/4 (75.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 226 | C → Y | 0.005435 | SNP | Missense Mutation | ESCA |
| 248 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 385 | S → C | 0.003460 | SNP | Missense Mutation | CESC |
| 543 | R → C | 0.005618 | SNP | Missense Mutation | PAAD |
| 619 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 633 | R → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 634 | R → C | 0.002506 | SNP | Missense Mutation | COAD |