Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A0A385KNS5 | CD44 | CD44 antigen (Extracellular matrix receptor … | Homo sapiens (Human) | 361 aa |
Protein Details: A0A385KNS5 (CD44)
Protein Information
| Accession | A0A385KNS5 |
|---|---|
| Protein Names | CD44 antigen (Extracellular matrix receptor III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (Phagocytic glycoprotein I) |
| Gene Symbol | CD44 |
| Organism | Homo sapiens (Human) |
| Length | 361 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19801377 22496122 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MDKFWWHAAW11GLCLVPLSLA21QIDLNITCRF31AGVFHVEKNG41RYSISRTEAA
51-10051DLCKAFNSTL61PTMAQMEKAL71SIGFETCRYG81FIEGHVVIPR91IQPNSICAAN
101-150101NTGVYILTSN111TSQYDTYCFN121ASAPPEEDCT131SVTDLPNAFD141GPITITIVNR
151-200151DGTRYVQKGE161YRTNPEDIYP171SNPTDDDVSS181GSSSERSSTS191GGYIFYTFST
201-250201VHPIPDEDSP211WITDSTDRIP221ATRDQDTFHP231SGGSHTTHGS241ESDGHSHGSQ
251-300251EGGANTTSGP261IRTPQIPEWL271IILASLLALA281LILAVCIAVN291SRRRCGQKKK
301-350301LVINSGNGAV311EDRKPSGLNG321EASKSQEMVH331LVNKESSETP341DQFMTADETR
351-361351NLQNVDMKIG361V
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 13 | CD44 antigen-like | - | - |
Deep-Palm: 0.04
|
|
| 28 | CD44 antigen-like C-type lectin fold | - | - |
GPS-Palm: 0.65
Deep-Palm: 0.86
|
|
| 53 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.86
|
|
| 77 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.80
Deep-Palm: 0.74
|
|
| 97 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.37
|
|
| 118 | - | - | - |
Deep-Palm: 0.15
|
|
| 129 | - | - | - |
Deep-Palm: 0.08
|
|
| 286 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.98
|
|
| 295 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.97
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
1
EC cell
Specificity: 0.167
1/1 (100.0%)
1
DU145 cell
Specificity: 0.167
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.667
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 28 | C → C | 0.002288 | SNP | Silent | STAD |
| 29 | R → C | 0.001969 | SNP | Missense Mutation | LGG |
| 41 | R → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 199 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 245 | F → C | 0.005618 | SNP | Missense Mutation | PAAD |
| 359 | W → C | 0.002288 | SNP | Missense Mutation | STAD |
| 542 | G → C | 0.002545 | SNP | Missense Mutation | GBM |