Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
A0A7I2V3F1 ACO2 Aconitate hydratase, mitochondrial (Aconitase) (EC … Homo sapiens (Human) 788 aa

Protein Details: A0A7I2V3F1 (ACO2)

Protein Information
Accession A0A7I2V3F1
Protein Names Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3)
Gene Symbol ACO2
Organism Homo sapiens (Human)
Length 788 aa
Isoforms No isoforms
Related PMIDs 21076176 26876311 32944167
Database Sources No database sources
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
3
PC3 cells
Specificity: 0.500
3/4 (75.0%)
2
Jurkat T cells
Specificity: 0.333
2/25 (8.0%)
1
Prefrontal cortex
Specificity: 0.167
1/1 (100.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MAPYSLLVTR11LQVKASPAQS21AFLALSLPRK31KRGPKQRRPG41EERRHLFLLF
51-10051EDSIACSRGV61CFHSSRLNRP71LTLSEKIVYG81HLDDPASQEI91ERGKSYLRLR
101-150101PDRVAMQDAT111AQMAMLQFIS121SGLSKVAVPS131TIHCDHLIEA141QVGGEKDLRR
151-200151AKDINQEVYN161FLATAGAKYG171VGFWKPGSGI181IHQIILENYA191YPGVLLIGTD
201-250201SHTPNGGGLG211GICIGVGGAD221AVDVMAGIPW231ELKCPKVIGV241KLTGSLSGWS
251-300251SPKDVILKVA261GILTVKGGTG271AIVEYHGPGV281DSISCTGMAT291ICNMGAEIGA
301-350301TTSVFPYNHR311MKKYLSKTGR321EDIANLADEF331KDHLVPDPGC341HYDQLIEINL
351-400351SELKPHINGP361FTPDLAHPVA371EVGKVAEKEG381WPLDIRVGLI391GSCTNSSYED
401-450401MGRSAAVAKQ411ALAHGLKCKS421QFTITPGSEQ431IRATIERDGY441AQILRDLGGI
451-500451VLANACGPCI461GQWDRKDIKK471GEKNTIVTSY481NRNFTGRNDA491NPETHAFVTS
501-550501PEIVTALAIA511GTLKFNPETD521YLTGTDGKKF531RLEAPDADEL541PKGEFDPGQD
551-600551TYQHPPKDSS561GQHVDVSPTS571QRLQLLEPFD581KWDGKDLEDL591QILIKVKGKC
601-650601TTDHISAAGP611WLKFRGHLDN621ISNNLLIGAI631NIENGKANSV641RNAVTQEFGP
651-700651VPDTARYYKK661HGIRWVVIGD671ENYGEGSSRE681HAALEPRHLG691GRAIITKSFA
701-750701RIHETNLKKQ711GLLPLTFADP721ADYNKIHPVD731KLTIQGLKDF741TPGKPLKCII
751-788751KHPNGTQETI761LLNHTFNETQ771IEWFRAGSAL781NRMKELQQ
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
61 Prediction (Medium) - -
213 Prediction (Low) - -
234 Prediction (Medium) - -
393 Prediction (Medium) - -
418 Prediction (Medium) - -
456 Prediction (High) - -
459 Prediction (High) - -
600 Prediction (Low) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
56 R → C 0.002141 SNP Missense Mutation SKCM
141 R → C 0.001887 SNP Missense Mutation UCEC
279 G → C 0.002033 SNP Missense Mutation LUSC
564 R → C 0.003774 SNP Missense Mutation UCEC
633 R → C 0.002288 SNP Missense Mutation STAD
679 R → C 0.002427 SNP Missense Mutation BLCA
740 C → C 0.001887 SNP Silent UCEC
284* C → ? 0.002545 SNP Nonsense Mutation GBM