Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
A0A7I2V3U0 ACO2 Aconitate hydratase, mitochondrial (Aconitase) (EC … Homo sapiens (Human) 725 aa

Protein Details: A0A7I2V3U0 (ACO2)

Protein Information
Accession A0A7I2V3U0
Protein Names Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3)
Gene Symbol ACO2
Organism Homo sapiens (Human)
Length 725 aa
Isoforms No isoforms
Related PMIDs 21076176 26876311 32944167
Database Sources No database sources
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
3
PC3 cells
Specificity: 0.500
3/4 (75.0%)
2
Jurkat T cells
Specificity: 0.333
2/25 (8.0%)
1
Prefrontal cortex
Specificity: 0.167
1/1 (100.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MPRLNRPLTL11SEKIVYGHLD21DPASQEIERG31KSYLRLRPDR41VAMQDATAQM
51-10051AMLQFISSGL61SKVAVPSTIH71CDHLIEAQVG81GEKDLRRAKD91INQEVYNFLA
101-150101TAGAKYGVGF111WKPGSGIIHQ121IILENYAYPG131VLLIGTDSHT141PNGGGLGGIC
151-200151IGVGGADAVD161VMAGIPWELK171CPKVIGVKLT181GSLSGWSSPK191DVILKVAGIL
201-250201TVKGGTGAIV211EYHGPGVDSI221SCTGMATICN231MGAEIGATTS241VFPYNHRMKK
251-300251YLSKTGREDI261ANLADEFKDH271LVPDPGCHYD281QLIEINLSEL291KPHINGPFTP
301-350301DLAHPVAEVG311KVAEKEGWPL321DIRVGLIGSC331TNSSYEDMGR341SAAVAKQALA
351-400351HGLKCKSQFT361ITPGSEQIRA371TIERDGYAQI381LRDLGGIVLA391NACGPCIGQW
401-450401DRKDIKKGEK411NTIVTSYNRN421FTGRNDANPE431THAFVTSPEI441VTALAIAGTL
451-500451KFNPETDYLT461GTDGKKFRLE471APDADELPKG481EFDPGQDTYQ491HPPKDSSGQH
501-550501VDVSPTSQRL511QLLEPFDKWD521GKDLEDLQIL531IKVKGKCTTD541HISAAGPWLK
551-600551FRGHLDNISN561NLLIGAINIE571NGKANSVRNA581VTQEFGPVPD591TARYYKKHGI
601-650601RWVVIGDENY611GEGSSREHAA621LEPRHLGGRA631IITKSFARIH641ETNLKKQGLL
651-700651PLTFADPADY661NKIHPVDKLT671IQGLKDFTPG681KPLKCIIKHP691NGTQETILLN
701-725701HTFNETQIEW711FRAGSALNRM721KELQQ
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
150 Prediction (Low) - -
171 Prediction (Medium) - -
330 Prediction (Medium) - -
355 Prediction (Medium) - -
393 Prediction (High) - -
396 Prediction (High) - -
537 Prediction (Low) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
56 R → C 0.002141 SNP Missense Mutation SKCM
141 R → C 0.001887 SNP Missense Mutation UCEC
279 G → C 0.002033 SNP Missense Mutation LUSC
564 R → C 0.003774 SNP Missense Mutation UCEC
633 R → C 0.002288 SNP Missense Mutation STAD
679 R → C 0.002427 SNP Missense Mutation BLCA
740 C → C 0.001887 SNP Silent UCEC
284* C → ? 0.002545 SNP Nonsense Mutation GBM