Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
A0A7I2V586 ACO2 Aconitate hydratase, mitochondrial (Aconitase) (EC … Homo sapiens (Human) 747 aa

Protein Details: A0A7I2V586 (ACO2)

Protein Information
Accession A0A7I2V586
Protein Names Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3)
Gene Symbol ACO2
Organism Homo sapiens (Human)
Length 747 aa
Isoforms No isoforms
Related PMIDs 21076176 26876311 32944167
Database Sources No database sources
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
3
PC3 cells
Specificity: 0.500
3/4 (75.0%)
2
Jurkat T cells
Specificity: 0.333
2/25 (8.0%)
1
Prefrontal cortex
Specificity: 0.167
1/1 (100.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MSHFEPNEYI11HYDLLEKNIN21IVRKRLNRPL31TLSEKIVYGH41LDDPASQEIE
51-10051RGKSYLRLRP61DRVAMQDATA71QMAMLQFISS81GLSKVAVPST91IHCDHLIEAQ
101-150101VGGEKDLRRA111KDINQEVYNF121LATAGAKYGV131GFWKPGSGII141HQIILENYAY
151-200151PGVLLIGTDS161HTPNGGGLGG171ICIGVGGADA181VDVMAGIPWE191LKCPKVIGVK
201-250201LTGSLSGWSS211PKDVILKVAG221ILTVKGGTGA231IVEYHGPGVD241SISCTGMATI
251-300251CNMGAEIGAT261TSVFPYNHRM271KKYLSKTGRE281DIANLADEFK291DHLVPDPGCH
301-350301YDQLIEINLS311ELKPHINGPF321TPDLAHPVAE331VGKVAEKEGW341PLDIRVGLIG
351-400351SCTNSSYEDM361GRSAAVAKQA371LAHGLKCKSQ381FTITPGSEQI391RATIERDGYA
401-450401QILRDLGGIV411LANACGPCIG421QWDRKDIKKG431EKNTIVTSYN441RNFTGRNDAN
451-500451PETHAFVTSP461EIVTALAIAG471TLKFNPETDY481LTGTDGKKFR491LEAPDADELP
501-550501KGEFDPGQDT511YQHPPKDSSG521QHVDVSPTSQ531RLQLLEPFDK541WDGKDLEDLQ
551-600551ILIKVKGKCT561TDHISAAGPW571LKFRGHLDNI581SNNLLIGAIN591IENGKANSVR
601-650601NAVTQEFGPV611PDTARYYKKH621GIRWVVIGDE631NYGEGSSREH641AALEPRHLGG
651-700651RAIITKSFAR661IHETNLKKQG671LLPLTFADPA681DYNKIHPVDK691LTIQGLKDFT
701-747701PGKPLKCIIK711HPNGTQETIL721LNHTFNETQI731EWFRAGSALN741RMKELQQ
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
172 Prediction (Low) - -
193 Prediction (Medium) - -
352 Prediction (Medium) - -
377 Prediction (Medium) - -
415 Prediction (High) - -
418 Prediction (High) - -
559 Prediction (Low) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
56 R → C 0.002141 SNP Missense Mutation SKCM
141 R → C 0.001887 SNP Missense Mutation UCEC
279 G → C 0.002033 SNP Missense Mutation LUSC
564 R → C 0.003774 SNP Missense Mutation UCEC
633 R → C 0.002288 SNP Missense Mutation STAD
679 R → C 0.002427 SNP Missense Mutation BLCA
740 C → C 0.001887 SNP Silent UCEC
284* C → ? 0.002545 SNP Nonsense Mutation GBM