Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A0A7I2V586 | ACO2 | Aconitate hydratase, mitochondrial (Aconitase) (EC … | Homo sapiens (Human) | 747 aa |
Protein Details: A0A7I2V586 (ACO2)
Protein Information
| Accession | A0A7I2V586 |
|---|---|
| Protein Names | Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) |
| Gene Symbol | ACO2 |
| Organism | Homo sapiens (Human) |
| Length | 747 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26876311 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSHFEPNEYI11HYDLLEKNIN21IVRKRLNRPL31TLSEKIVYGH41LDDPASQEIE
51-10051RGKSYLRLRP61DRVAMQDATA71QMAMLQFISS81GLSKVAVPST91IHCDHLIEAQ
101-150101VGGEKDLRRA111KDINQEVYNF121LATAGAKYGV131GFWKPGSGII141HQIILENYAY
151-200151PGVLLIGTDS161HTPNGGGLGG171ICIGVGGADA181VDVMAGIPWE191LKCPKVIGVK
201-250201LTGSLSGWSS211PKDVILKVAG221ILTVKGGTGA231IVEYHGPGVD241SISCTGMATI
251-300251CNMGAEIGAT261TSVFPYNHRM271KKYLSKTGRE281DIANLADEFK291DHLVPDPGCH
301-350301YDQLIEINLS311ELKPHINGPF321TPDLAHPVAE331VGKVAEKEGW341PLDIRVGLIG
351-400351SCTNSSYEDM361GRSAAVAKQA371LAHGLKCKSQ381FTITPGSEQI391RATIERDGYA
401-450401QILRDLGGIV411LANACGPCIG421QWDRKDIKKG431EKNTIVTSYN441RNFTGRNDAN
451-500451PETHAFVTSP461EIVTALAIAG471TLKFNPETDY481LTGTDGKKFR491LEAPDADELP
501-550501KGEFDPGQDT511YQHPPKDSSG521QHVDVSPTSQ531RLQLLEPFDK541WDGKDLEDLQ
551-600551ILIKVKGKCT561TDHISAAGPW571LKFRGHLDNI581SNNLLIGAIN591IENGKANSVR
601-650601NAVTQEFGPV611PDTARYYKKH621GIRWVVIGDE631NYGEGSSREH641AALEPRHLGG
651-700651RAIITKSFAR661IHETNLKKQG671LLPLTFADPA681DYNKIHPVDK691LTIQGLKDFT
701-747701PGKPLKCIIK711HPNGTQETIL721LNHTFNETQI731EWFRAGSALN741RMKELQQ
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 93 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.92
|
|
| 172 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.83
|
|
| 193 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.96
|
|
| 244 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.29
|
|
| 251 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.34
|
|
| 299 | - | - | - |
Deep-Palm: 0.70
|
|
| 352 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
|
GPS-Palm: 0.86
Deep-Palm: 0.96
|
|
| 377 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.97
|
|
| 415 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.94
Deep-Palm: 0.97
|
|
| 418 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.94
Deep-Palm: 0.96
|
|
| 559 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
GPS-Palm: 0.76
Deep-Palm: 0.89
|
|
| 707 | - | - | - |
Deep-Palm: 0.94
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
frontal cortex
Specificity: 0.167
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.667
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.167
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 56 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 141 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 279 | G → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 564 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |
| 633 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 679 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 740 | C → C | 0.001887 | SNP | Silent | UCEC |
| 284* | C → ? | 0.002545 | SNP | Nonsense Mutation | GBM |