Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A0A7I2V614 | ACO2 | Aconitate hydratase, mitochondrial (Aconitase) (EC … | Homo sapiens (Human) | 731 aa |
Protein Details: A0A7I2V614 (ACO2)
Protein Information
| Accession | A0A7I2V614 |
|---|---|
| Protein Names | Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) |
| Gene Symbol | ACO2 |
| Organism | Homo sapiens (Human) |
| Length | 731 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26876311 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAPYSLLVTR11LQKALGVRQY21HVASVLCQRA31KVAMSHFEPN41EYIHYDLLEK
51-10051NINIVRKRLN61RPLTLSEKIV71YGHLDDPASQ81EIERGKSYLR91LRPDRVAMQD
101-150101ATAQMAMLQF111ISSGLSKVAV121PSTIHCDHLI131EAQVGGEKDL141RRAKDINQEV
151-200151YNFLATAGAK161YGVGFWKPGS171GIIHQIILEN181YAYPGVLLIG191TDSHTPNGGG
201-250201LGGICIGVGG211ADAVDVMAGI221PWELKCPKVI231GVKLTGSLSG241WSSPKDVILK
251-300251VAGILTVKGG261TGAIVEYHGP271GVDSISCTGM281ATICNMGAEI291GATTSVFPYN
301-350301HRMKKYLSKT311GREDIANLAD321EFKDHLVPDP331GCHYDQLIEI341NLSELKPHIN
351-400351GPFTPDLAHP361VAEVGKVAEK371EGWPLDIRVG381LIGSCTNSSY391EDMGRSAAVA
401-450401KQALAHGLKC411KSQFTITPGS421EQIRATIERD431GYAQILRDLG441GIVLANACGP
451-500451CIGQWDRKDI461KKGEKNTIVT471SYNRNFTGRN481DANPETHAFV491TSPEIVTALA
501-550501IAGTLKFNPE511TDYLTGTDGK521KFRLEAPDAD531ELPKGEFDPG541QDTYQHPPKD
551-600551SSGQHVDVSP561TSQRLQLLEP571FDKWDGKDLE581DLQILIKVKG591KCTTDHISAA
601-650601GPWLKFRGHL611DNISNNLLIG621AINIENGKAN631SVRNAVTQEF641GPVPDTARYY
651-700651KAAGEEGPLQ661PLYREPQDAQ671APETWHQVGG681DRRRELRRGL691EPGACSSGAS
701-731701PPWGPGHHHQ711ELCQDPRDQP721EETGPAASDL731R
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 27 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.89
|
|
| 126 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.92
|
|
| 205 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.83
|
|
| 226 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.96
|
|
| 277 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.29
|
|
| 284 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.34
|
|
| 332 | - | - | - |
Deep-Palm: 0.70
|
|
| 385 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
|
GPS-Palm: 0.86
Deep-Palm: 0.96
|
|
| 410 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.97
|
|
| 448 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.94
Deep-Palm: 0.97
|
|
| 451 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.94
Deep-Palm: 0.96
|
|
| 592 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
GPS-Palm: 0.76
Deep-Palm: 0.89
|
|
| 695 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.96
|
|
| 713 | - | - | - |
Deep-Palm: 0.30
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
frontal cortex
Specificity: 0.167
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.667
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.167
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 56 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 141 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 279 | G → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 564 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |
| 633 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 679 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 740 | C → C | 0.001887 | SNP | Silent | UCEC |
| 284* | C → ? | 0.002545 | SNP | Nonsense Mutation | GBM |