Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
A0A7I2V614 ACO2 Aconitate hydratase, mitochondrial (Aconitase) (EC … Homo sapiens (Human) 731 aa

Protein Details: A0A7I2V614 (ACO2)

Protein Information
Accession A0A7I2V614
Protein Names Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3)
Gene Symbol ACO2
Organism Homo sapiens (Human)
Length 731 aa
Isoforms No isoforms
Related PMIDs 21076176 26876311 32944167
Database Sources No database sources
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
3
PC3 cells
Specificity: 0.500
3/4 (75.0%)
2
Jurkat T cells
Specificity: 0.333
2/25 (8.0%)
1
Prefrontal cortex
Specificity: 0.167
1/1 (100.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MAPYSLLVTR11LQKALGVRQY21HVASVLCQRA31KVAMSHFEPN41EYIHYDLLEK
51-10051NINIVRKRLN61RPLTLSEKIV71YGHLDDPASQ81EIERGKSYLR91LRPDRVAMQD
101-150101ATAQMAMLQF111ISSGLSKVAV121PSTIHCDHLI131EAQVGGEKDL141RRAKDINQEV
151-200151YNFLATAGAK161YGVGFWKPGS171GIIHQIILEN181YAYPGVLLIG191TDSHTPNGGG
201-250201LGGICIGVGG211ADAVDVMAGI221PWELKCPKVI231GVKLTGSLSG241WSSPKDVILK
251-300251VAGILTVKGG261TGAIVEYHGP271GVDSISCTGM281ATICNMGAEI291GATTSVFPYN
301-350301HRMKKYLSKT311GREDIANLAD321EFKDHLVPDP331GCHYDQLIEI341NLSELKPHIN
351-400351GPFTPDLAHP361VAEVGKVAEK371EGWPLDIRVG381LIGSCTNSSY391EDMGRSAAVA
401-450401KQALAHGLKC411KSQFTITPGS421EQIRATIERD431GYAQILRDLG441GIVLANACGP
451-500451CIGQWDRKDI461KKGEKNTIVT471SYNRNFTGRN481DANPETHAFV491TSPEIVTALA
501-550501IAGTLKFNPE511TDYLTGTDGK521KFRLEAPDAD531ELPKGEFDPG541QDTYQHPPKD
551-600551SSGQHVDVSP561TSQRLQLLEP571FDKWDGKDLE581DLQILIKVKG591KCTTDHISAA
601-650601GPWLKFRGHL611DNISNNLLIG621AINIENGKAN631SVRNAVTQEF641GPVPDTARYY
651-700651KAAGEEGPLQ661PLYREPQDAQ671APETWHQVGG681DRRRELRRGL691EPGACSSGAS
701-731701PPWGPGHHHQ711ELCQDPRDQP721EETGPAASDL731R
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
27 Prediction (Medium) - -
205 Prediction (Low) - -
226 Prediction (Medium) - -
385 Prediction (Medium) - -
410 Prediction (Medium) - -
448 Prediction (High) - -
451 Prediction (High) - -
592 Prediction (Low) - -
695 Prediction (Medium) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
56 R → C 0.002141 SNP Missense Mutation SKCM
141 R → C 0.001887 SNP Missense Mutation UCEC
279 G → C 0.002033 SNP Missense Mutation LUSC
564 R → C 0.003774 SNP Missense Mutation UCEC
633 R → C 0.002288 SNP Missense Mutation STAD
679 R → C 0.002427 SNP Missense Mutation BLCA
740 C → C 0.001887 SNP Silent UCEC
284* C → ? 0.002545 SNP Nonsense Mutation GBM