Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A0A7P0TAE9 | CANX | Calnexin | Homo sapiens (Human) | 626 aa |
Protein Details: A0A7P0TAE9 (CANX)
Protein Information
| Accession | A0A7P0TAE9 |
|---|---|
| Protein Names | Calnexin |
| Gene Symbol | CANX |
| Organism | Homo sapiens (Human) |
| Length | 626 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 19801377 21076176 22496122 26876311 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MEGKWLLCML11LVLGTAIVEA21HDGHDDDVID31IEDDLDDVIE41EVEDSKPDTT
51-10051APPSSPKVTY61KAPVPTGEVY71FADSFDRGTL81SGWILSKAKK91DDTDDEIAKY
101-150101DGKWEVEEMK111ESKLPGDKGL121VLMSRAKHHA131ISAKLNKPFL141FDTKPLIVQY
151-200151EVNFQNGIEC161GGAYVKLLSK171TPELNLDQFH181DKTPYTIMFG191PDKCGEDYKL
201-250201HFIFRHKNPK211TGIYEEKHAK221RPDADLKTYF231TDKKTHLYTL241KSRGTNHLCF
251-300251VHKEMGVSFP261KTPGARHCSY271PKASVLNPDN281SFEILVDQSV291VNSGNLLNDM
301-350301TPPVNPSREI311EDPEDRKPED321WDERPKIPDP331EAVKPDDWDE341DAPAKIPDEE
351-400351ATKPEGWLDD361EPEYVPDPDA371EKPEDWDEDM381DGEWEAPQIA391NPRCESAPGC
401-450401GVWQRPVIDN411PNYKGKWKPP421MIDNPSYQGI431WKPRKIPNPD441FFEDLEPFRM
451-500451TPFSAIGLEL461WSMTSDIFFD471NFIICADRRI481VDDWANDGWG491LKKAADGAAE
501-550501PGVVGQMIEA511AEERPWLWVV521YILTVALPVF531LVILFCCSGK541KQTSGMEYKK
551-600551TDAPQPDVKE561EEEEKEEEKD571KGDEEEEGEE581KLEEKQKSDA591EEDGGTVSQE
601-626601EEDRKPKAEE611DEILNRSPRN621RKPRRE
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 8 | - | - | - |
Deep-Palm: 0.05
|
|
| 160 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.44
|
|
| 194 | - | - | - |
Deep-Palm: 0.12
|
|
| 249 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.39
|
|
| 268 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.68
|
|
| 394 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.15
|
|
| 400 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.81
Deep-Palm: 0.35
|
|
| 475 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.05
|
|
| 536 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.96
|
|
| 537 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.96
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.400
4
PC3
Specificity: 0.267
4/4 (100.0%)
3
Jurkat T cell
Specificity: 0.200
3/3 (100.0%)
1
EC cell
Specificity: 0.067
1/1 (100.0%)
1
frontal cortex
Specificity: 0.067
1/1 (100.0%)
1
DU145 cell
Specificity: 0.067
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.267
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.067
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 438 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 456 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 480 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |