Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A0A8V8TQ14 | CLTC | Clathrin heavy chain | Homo sapiens (Human) | 1680 aa |
Protein Details: A0A8V8TQ14 (CLTC)
Protein Information
| Accession | A0A8V8TQ14 |
|---|---|
| Protein Names | Clathrin heavy chain |
| Gene Symbol | CLTC |
| Organism | Homo sapiens (Human) |
| Length | 1680 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 21076176 26876311 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAQILPIRFQ11EHLQLQNLGI21NPANIGFSTL31TMESDKFICI41REKVGEQAQV
51-10051VIIDMNDPSN61PIRRPISADS71AIMNPASKVI81ALKGIKEYAG91KTLQIFNIEM
101-150101KSKMKAHTMT111DDVTFWKWIS121LNTVALVTDN131AVYHWSMEGE141SQPVKMFDRH
151-200151SSLAGCQIIN161YRTDAKQKWL171LLTGISAQQN181RVVGAMQLYS191VDRKVSQPIE
201-250201GHAASFAQFK211MEGNAEESTL221FCFAVRGQAG231GKLHIIEVGT241PPTGNQPFPK
251-300251KAVDVFFPPE261AQNDFPVAMQ271ISEKHDVVFL281ITKYGYIHLY291DLETGTCIYM
301-350301NRISGETIFV311TAPHEATAGI321IGVNRKGQVL331SVCVEEENII341PYITNVLQNP
351-400351DLALRMAVRN361NLAGAEELFA371RKFNALFAQG381NYSEAAKVAA391NAPKGILRTP
401-450401DTIRRFQSVP411AQPGQTSPLL421QYFGILLDQG431QLNKYESLEL441CRPVLQQGRK
451-500451QLLEKWLKED461KLECSEELGD471LVKSVDPTLA481LSVYLRANVP491NKVIQCFAET
501-550501GQVQKIVLYA511KKVGYTPDWI521FLLRNVMRIS531PDQGQQFAQM541LVQDEEPLAD
551-600551ITQIVDVFME561YNLIQQCTAF571LLDALKNNRP581SEGPLQTRLL591EMNLMHAPQV
601-650601ADAILGNQMF611THYDRAHIAQ621LCEKAGLLQR631ALEHFTDLYD641IKRAVVHTHL
651-700651LNPEWLVNYF661GSLSVEDSLE671CLRAMLSANI681RQNLQICVQV691ASKYHEQLST
701-750701QSLIELFESF711KSFEGLFYFL721GSIVNFSQDP731DVHFKYIQAA741CKTGQIKEVE
751-800751RICRESNCYD761PERVKNFLKE771AKLTDQLPLI781IVCDRFDFVH791DLVLYLYRNN
801-850801LQKYIEIYVQ811KVNPSRLPVV821IGGLLDVDCS831EDVIKNLILV841VRGQFSTDEL
851-900851VAEVEKRNRL861KLLLPWLEAR871IHEGCEEPAT881HNALAKIYID891SNNNPERFLR
901-950901ENPYYDSRVV911GKYCEKRDPH921LACVAYERGQ931CDLELINVCN941ENSLFKSLSR
951-1000951YLVRRKDPEL961WGSVLLESNP971YRRPLIDQVV981QTALSETQDP991EEVSVTVKAF
1001-10501001MTADLPNELI1011ELLEKIVLDN1021SVFSEHRNLQ1031NLLILTAIKA1041DRTRVMEYIN
1051-11001051RLDNYDAPDI1061ANIAISNELF1071EEAFAIFRKF1081DVNTSAVQVL1091IEHIGNLDRA
1101-11501101YEFAERCNEP1111AVWSQLAKAQ1121LQKGMVKEAI1131DSYIKADDPS1141SYMEVVQAAN
1151-12001151TSGNWEELVK1161YLQMARKKAR1171ESYVETELIF1181ALAKTNRLAE1191LEEFINGPNN
1201-12501201AHIQQVGDRC1211YDEKMYDAAK1221LLYNNVSNFG1231RLASTLVHLG1241EYQAAVDGAR
1251-13001251KANSTRTWKE1261VCFACVDGKE1271FRLAQMCGLH1281IVVHADELEE1291LINYYQDRGY
1301-13501301FEELITMLEA1311ALGLERAHMG1321MFTELAILYS1331KFKPQKMREH1341LELFWSRVNI
1351-14001351PKVLRAAEQA1361HLWAELVFLY1371DKYEEYDNAI1381ITMMNHPTDA1391WKEGQFKDII
1401-14501401TKVANVELYY1411RAIQFYLEFK1421PLLLNDLLMV1431LSPRLDHTRA1441VNYFSKVKQL
1451-15001451PLVKPYLRSV1461QNHNNKSVNE1471SLNNLFITEE1481DYQALRTSID1491AYDNFDNISL
1501-15501501AQRLEKHELI1511EFRRIAAYLF1521KGNNRWKQSV1531ELCKKDSLYK1541DAMQYASESK
1551-16001551DTELAEELLQ1561WFLQEEKREC1571FGACLFTCYD1581LLRPDVVLET1591AWRHNIMDFA
1601-16501601MPYFIQVMKE1611YLTKVDKLDA1621SESLRKEEEQ1631ATETQPIVYG1641QPQLMLTAGP
1651-16801651SVAVPPQAPF1661GYGYTAPPYG1671QPQPGFGYSM
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 39 | CLATHRIN HEAVY CHAIN RELATED Clathrin heavy chain, N-terminal Clathrin, heavy chain, propeller repeat | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.87
|
|
| 156 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.89
Deep-Palm: 0.73
|
|
| 222 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.66
Deep-Palm: 0.87
|
|
| 297 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.15
|
|
| 333 | - | - | - |
Deep-Palm: 0.86
|
|
| 441 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.86
Deep-Palm: 0.98
|
|
| 464 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.98
|
|
| 496 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.88
Deep-Palm: 0.92
|
|
| 567 | - | - | - |
Deep-Palm: 0.48
|
|
| 622 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.82
Deep-Palm: 0.85
|
|
| 671 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.94
|
|
| 687 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.82
|
|
| 741 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.56
|
|
| 753 | - | - | - |
Deep-Palm: 0.49
|
|
| 758 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.95
|
|
| 783 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.80
Deep-Palm: 0.96
|
|
| 829 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.96
|
|
| 875 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.98
|
|
| 914 | - | - | - |
Deep-Palm: 0.89
|
|
| 923 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.90
|
|
| 931 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
Deep-Palm: 0.41
|
|
| 939 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.86
Deep-Palm: 0.91
|
|
| 1107 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
Deep-Palm: 0.66
|
|
| 1210 | - | - | - |
Deep-Palm: 0.08
|
|
| 1262 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.84
Deep-Palm: 0.76
|
|
| 1265 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.50
|
|
| 1277 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.86
|
|
| 1533 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.70
|
|
| 1570 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.79
|
|
| 1574 | - | - | - |
Deep-Palm: 0.71
|
|
| 1578 | - | - | - |
Deep-Palm: 0.94
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
PC3
Specificity: 0.364
4/4 (100.0%)
2
Jurkat T cell
Specificity: 0.182
2/2 (100.0%)
1
frontal cortex
Specificity: 0.091
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.364
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 176 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 294 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 305 | V → Cfs*6 | 0.002976 | INS | Frame Shift Ins | KIRC |
| 328 | C → Ffs*9 | 0.002747 | DEL | Frame Shift Del | LIHC |
| 354 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 655 | F → C | 0.001969 | SNP | Missense Mutation | LGG |
| 895 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 903 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 903 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 923 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1189 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1210 | M → Cfs*52 | 0.002506 | DEL | Frame Shift Del | COAD |
| 1289 | Y → C | 0.002294 | SNP | Missense Mutation | OV |
| 1544 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| ? | ? → ? | 0.001014 | SNP | Missense Mutation | BRCA |