Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A0A8V8TQ18 | CLTC | Clathrin heavy chain | Homo sapiens (Human) | 1721 aa |
Protein Details: A0A8V8TQ18 (CLTC)
Protein Information
| Accession | A0A8V8TQ18 |
|---|---|
| Protein Names | Clathrin heavy chain |
| Gene Symbol | CLTC |
| Organism | Homo sapiens (Human) |
| Length | 1721 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 21076176 26876311 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAQILPIRFQ11EHLQLQNLGI21NPANIGFSTL31TMESDKFICI41REKVGEQAQV
51-10051VIIDMNDPSN61PIRRPISADS71AIMNPASKVI81ALKAGKTLQI91FNIEMKSKMK
101-150101AHTMTDDVTF111WKWISLNTVA121LVTDNAVYHW131SMEGESQPVK141MFDRHSSLAG
151-200151CQIINYRTDA161KQKWLLLTGI171SAQQNRVVGA181MQLYSVDRKV191SQPIEGHAAS
201-250201FAQFKMEGNA211EESTLFCFAV221RGQAGGKLHI231IEVGTPPTGN241QPFPKKAVDV
251-300251FFPPEAQNDF261PVAMQISEKH271DVVFLITKYG281YIHLYDLETG291TCIYMNRISG
301-350301ETIFVTAPHE311ATAGIIGVNR321KGQVLSVCVE331EENIIPYITN341VLQNPDLALR
351-400351MAVRNNLAGA361EELFARKFNA371LFAQGNYSEA381AKVAANAPKG391ILRTPDTIRR
401-450401FQSVPAQPGQ411TSPLLQYFGI421LLDQGQLNKY431ESLELCRPVL441QQGRKQLLEK
451-500451WLKEDKLECS461EELGDLVKSV471DPTLALSVYL481RANVPNKVIQ491CFAETGQVQK
501-550501IVLYAKKVGY511TPDWIFLLRN521VMRISPDQGQ531QFAQMLVQDE541EPLADITQIV
551-600551DVFMEYNLIQ561QCTAFLLDAL571KNNRPSEGPL581QTRLLEMNLM591HAPQVADAIL
601-650601GNQMFTHYDR611AHIAQLCEKA621GLLQRALEHF631TDLYDIKRAV641VHTHLLNPEW
651-700651LVNYFGSLSV661EDSLECLRAM671LSANIRQNLQ681ICVQVASKYH691EQLSTQSLIE
701-750701LFESFKSFEG711LFYFLGSIVN721FSQDPDVHFK731YIQAACKTGQ741IKEVERICRE
751-800751SNCYDPERVK761NFLKEAKLTD771QLPLIIVCDR781FDFVHDLVLY791LYRNNLQKYI
801-850801EIYVQKGLAL811SPMLEYSGTI821TAHSNLKLLG831SSSPPALASK841YLGLQVNPSR
851-900851LPVVIGGLLD861VDCSEDVIKN871LILVVRGQFS881TDELVAEVEK891RNRLKLLLPW
901-950901LEARIHEGCE911EPATHNALAK921IYIDSNNNPE931RFLRENPYYD941SRVVGKYCEK
951-1000951RDPHLACVAY961ERGQCDLELI971NVCNENSLFK981SLSRYLVRRK991DPELWGSVLL
1001-10501001ESNPYRRPLI1011DQVVQTALSE1021TQDPEEVSVT1031VKAFMTADLP1041NELIELLEKI
1051-11001051VLDNSVFSEH1061RNLQNLLILT1071AIKADRTRVM1081EYINRLDNYD1091APDIANIAIS
1101-11501101NELFEEAFAI1111FRKFDVNTSA1121VQVLIEHIGN1131LDRAYEFAER1141CNEPAVWSQL
1151-12001151AKAQLQKGMV1161KEAIDSYIKA1171DDPSSYMEVV1181QAANTSGNWE1191ELVKYLQMAR
1201-12501201KKARESYVET1211ELIFALAKTN1221RLAELEEFIN1231GPNNAHIQQV1241GDRCYDEKMY
1251-13001251DAAKLLYNNV1261SNFGRLASTL1271VHLGEYQAAV1281DGARKANSTR1291TWKEVCFACV
1301-13501301DGKEFRLAQM1311CGLHIVVHAD1321ELEELINYYQ1331DRGYFEELIT1341MLEAALGLER
1351-14001351AHMGMFTELA1361ILYSKFKPQK1371MREHLELFWS1381RVNIPKVLRA1391AEQAHLWAEL
1401-14501401VFLYDKYEEY1411DNAIITMMNH1421PTDAWKEGQF1431KDIITKVANV1441ELYYRAIQFY
1451-15001451LEFKPLLLND1461LLMVLSPRLD1471HTRAVNYFSK1481VKQLPLVKPY1491LRSVQNHNNK
1501-15501501SVNESLNNLF1511ITEEDYQALR1521TSIDAYDNFD1531NISLAQRLEK1541HELIEFRRIA
1551-16001551AYLFKGNNRW1561KQSVELCKKD1571SLYKDAMQYA1581SESKDTELAE1591ELLQWFLQEE
1601-16501601KRECFGACLF1611TCYDLLRPDV1621VLETAWRHNI1631MDFAMPYFIQ1641VMKEYLTKVD
1651-17001651AIKEKVDKLD1661ASESLRKEEE1671QATETQPIVY1681GQPQLMLTAG1691PSVAVPPQAP
1701-17211701FGYGYTAPPY1711GQPQPGFGYS1721M
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 39 | CLATHRIN HEAVY CHAIN RELATED Clathrin heavy chain, N-terminal Clathrin, heavy chain, propeller repeat | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.87
|
|
| 151 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.89
Deep-Palm: 0.73
|
|
| 217 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.66
Deep-Palm: 0.87
|
|
| 292 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.15
|
|
| 328 | - | - | - |
Deep-Palm: 0.86
|
|
| 436 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.86
Deep-Palm: 0.98
|
|
| 459 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.98
|
|
| 491 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.88
Deep-Palm: 0.92
|
|
| 562 | - | - | - |
Deep-Palm: 0.48
|
|
| 617 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.82
Deep-Palm: 0.85
|
|
| 666 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.94
|
|
| 682 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.82
|
|
| 736 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.56
|
|
| 748 | - | - | - |
Deep-Palm: 0.49
|
|
| 753 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.95
|
|
| 778 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.80
Deep-Palm: 0.96
|
|
| 863 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.96
|
|
| 909 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.98
|
|
| 948 | - | - | - |
Deep-Palm: 0.89
|
|
| 957 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.90
|
|
| 965 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
Deep-Palm: 0.41
|
|
| 973 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.86
Deep-Palm: 0.91
|
|
| 1141 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
Deep-Palm: 0.66
|
|
| 1244 | - | - | - |
Deep-Palm: 0.08
|
|
| 1296 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.84
Deep-Palm: 0.76
|
|
| 1299 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.50
|
|
| 1311 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.86
|
|
| 1567 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.70
|
|
| 1604 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.79
|
|
| 1608 | - | - | - |
Deep-Palm: 0.71
|
|
| 1612 | - | - | - |
Deep-Palm: 0.94
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
PC3
Specificity: 0.364
4/4 (100.0%)
2
Jurkat T cell
Specificity: 0.182
2/2 (100.0%)
1
frontal cortex
Specificity: 0.091
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.364
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 176 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 294 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 305 | V → Cfs*6 | 0.002976 | INS | Frame Shift Ins | KIRC |
| 328 | C → Ffs*9 | 0.002747 | DEL | Frame Shift Del | LIHC |
| 354 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 655 | F → C | 0.001969 | SNP | Missense Mutation | LGG |
| 895 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 903 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 903 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 923 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1189 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1210 | M → Cfs*52 | 0.002506 | DEL | Frame Shift Del | COAD |
| 1289 | Y → C | 0.002294 | SNP | Missense Mutation | OV |
| 1544 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| ? | ? → ? | 0.001014 | SNP | Missense Mutation | BRCA |