Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A0A8V8TQK3 | CLTC | Clathrin heavy chain | Homo sapiens (Human) | 1579 aa |
Protein Details: A0A8V8TQK3 (CLTC)
Protein Information
| Accession | A0A8V8TQK3 |
|---|---|
| Protein Names | Clathrin heavy chain |
| Gene Symbol | CLTC |
| Organism | Homo sapiens (Human) |
| Length | 1579 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 21076176 26876311 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAQILPIRFQ11EHLQLQNLGI21NPANIGFSTL31TMESDKFICI41REKVGEQAQV
51-10051VIIDMNDPSN61PIRRPISADS71AIMNPASKVI81ALKAGKTLQI91FNIEMKSKMK
101-150101AHTMTDDVTF111WKWISLNTVA121LVTDNAVYHW131SMEGESQPVK141MFDRHSSLAG
151-200151CQIINYRTDA161KQKWLLLTGI171SAQQNRVVGA181MQLYSVDRKV191SQPIEGHAAS
201-250201FAQFKMEGNA211EESTLFCFAV221RGQAGGKVLS231VCVEEENIIP241YITNVLQNPD
251-300251LALRMAVRNN261LAGAEELFAR271KFNALFAQGN281YSEAAKVAAN291APKGILRTPD
301-350301TIRRFQSVPA311QPGQTSPLLQ321YFGILLDQGQ331LNKYESLELC341RPVLQQGRKQ
351-400351LLEKWLKEDK361LECSEELGDL371VKSVDPTLAL381SVYLRANVPN391KVIQCFAETG
401-450401QVQKIVLYAK411KVGYTPDWIF421LLRNVMRISP431DQGQQFAQML441VQDEEPLADI
451-500451TQIVDVFMEY461NLIQQCTAFL471LDALKNNRPS481EGPLQTRLLE491MNLMHAPQVA
501-550501DAILGNQMFT511HYDRAHIAQL521CEKAGLLQRA531LEHFTDLYDI541KRAVVHTHLL
551-600551NPEWLVNYFG561SLSVEDSLEC571LRAMLSANIR581QNLQICVQVA591SKYHEQLSTQ
601-650601SLIELFESFK611SFEGLFYFLG621SIVNFSQDPD631VHFKYIQAAC641KTGQIKEVER
651-700651ICRESNCYDP661ERVKNFLKEA671KLTDQLPLII681VCDRFDFVHD691LVLYLYRNNL
701-750701QKYIEIYVQK711VNPSRLPVVI721GGLLDVDCSE731DVIKNLILVV741RGQFSTDELV
751-800751AEVEKRNRLK761LLLPWLEARI771HEGCEEPATH781NALAKIYIDS791NNNPERFLRE
801-850801NPYYDSRVVG811KYCEKRDPHL821ACVAYERGQC831DLELINVCNE841NSLFKSLSRY
851-900851LVRRKDPELW861GSVLLESNPY871RRPLIDQVVQ881TALSETQDPE891EVSVTVKAFM
901-950901TADLPNELIE911LLEKIVLDNS921VFSEHRNLQN931LLILTAIKAD941RTRVMEYINR
951-1000951LDNYDAPDIA961NIAISNELFE971EAFAIFRKFD981VNTSAVQVLI991EHIGNLDRAY
1001-10501001EFAERCNEPA1011VWSQLAKAQL1021QKGMVKEAID1031SYIKADDPSS1041YMEVVQAANT
1051-11001051SGNWEELVKY1061LQMARKKARE1071SYVETELIFA1081LAKTNRLAEL1091EEFINGPNNA
1101-11501101HIQQVGDRCY1111DEKMYDAAKL1121LYNNVSNFGR1131LASTLVHLGE1141YQAAVDGARK
1151-12001151ANSTRTWKEV1161CFACVDGKEF1171RLAQMCGLHI1181VVHADELEEL1191INYYQDRGYF
1201-12501201EELITMLEAA1211LGLERAHMGM1221FTELAILYSK1231FKPQKMREHL1241ELFWSRVNIP
1251-13001251KVLRAAEQAH1261LWAELVFLYD1271KYEEYDNAII1281TMMNHPTDAW1291KEGQFKDIIT
1301-13501301KVANVELYYR1311AIQFYLEFKP1321LLLNDLLMVL1331SPRLDHTRAV1341NYFSKVKQLP
1351-14001351LVKPYLRSVQ1361NHNNKSVNES1371LNNLFITEED1381YQALRTSIDA1391YDNFDNISLA
1401-14501401QRLEKHELIE1411FRRIAAYLFK1421GNNRWKQSVE1431LCKKDSLYKD1441AMQYASESKD
1451-15001451TELAEELLQW1461FLQEEKRECF1471GACLFTCYDL1481LRPDVVLETA1491WRHNIMDFAM
1501-15501501PYFIQVMKEY1511LTKVDKLDAS1521ESLRKEEEQA1531TETQPIVYGQ1541PQLMLTAGPS
1551-15791551VAVPPQAPFG1561YGYTAPPYGQ1571PQPGFGYSM
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 39 | CLATHRIN HEAVY CHAIN RELATED Clathrin heavy chain, N-terminal Clathrin, heavy chain, propeller repeat | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.87
|
|
| 151 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.89
Deep-Palm: 0.73
|
|
| 217 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.66
Deep-Palm: 0.93
|
|
| 232 | - | - | - |
Deep-Palm: 0.87
|
|
| 340 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.86
Deep-Palm: 0.98
|
|
| 363 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.98
|
|
| 395 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.88
Deep-Palm: 0.92
|
|
| 466 | - | - | - |
Deep-Palm: 0.48
|
|
| 521 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.82
Deep-Palm: 0.85
|
|
| 570 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.94
|
|
| 586 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.82
|
|
| 640 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.56
|
|
| 652 | - | - | - |
Deep-Palm: 0.49
|
|
| 657 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.95
|
|
| 682 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.80
Deep-Palm: 0.96
|
|
| 728 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.96
|
|
| 774 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.98
|
|
| 813 | - | - | - |
Deep-Palm: 0.89
|
|
| 822 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.90
|
|
| 830 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
Deep-Palm: 0.41
|
|
| 838 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.86
Deep-Palm: 0.91
|
|
| 1006 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
Deep-Palm: 0.66
|
|
| 1109 | - | - | - |
Deep-Palm: 0.08
|
|
| 1161 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.84
Deep-Palm: 0.76
|
|
| 1164 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.50
|
|
| 1176 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.86
|
|
| 1432 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.70
|
|
| 1469 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.79
|
|
| 1473 | - | - | - |
Deep-Palm: 0.71
|
|
| 1477 | - | - | - |
Deep-Palm: 0.94
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
PC3
Specificity: 0.364
4/4 (100.0%)
2
Jurkat T cell
Specificity: 0.182
2/2 (100.0%)
1
frontal cortex
Specificity: 0.091
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.364
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 176 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 294 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 305 | V → Cfs*6 | 0.002976 | INS | Frame Shift Ins | KIRC |
| 328 | C → Ffs*9 | 0.002747 | DEL | Frame Shift Del | LIHC |
| 354 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 655 | F → C | 0.001969 | SNP | Missense Mutation | LGG |
| 895 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 903 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 903 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 923 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1189 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1210 | M → Cfs*52 | 0.002506 | DEL | Frame Shift Del | COAD |
| 1289 | Y → C | 0.002294 | SNP | Missense Mutation | OV |
| 1544 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| ? | ? → ? | 0.001014 | SNP | Missense Mutation | BRCA |