Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A0A8V8TR47 | CLTC | Clathrin heavy chain | Homo sapiens (Human) | 1679 aa |
Protein Details: A0A8V8TR47 (CLTC)
Protein Information
| Accession | A0A8V8TR47 |
|---|---|
| Protein Names | Clathrin heavy chain |
| Gene Symbol | CLTC |
| Organism | Homo sapiens (Human) |
| Length | 1679 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 21076176 26876311 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAQILPIRFQ11EHLQLQNLGI21NPANIGFSTL31TMESDKFICI41REKVGEQAQV
51-10051VIIDMNDPSN61PIRRPISADS71AIMNPASKVI81ALKAGKTLQI91FNIEMKSKMK
101-150101AHTMTDDVTF111WKWISLNTVA121LVTDNAVYHW131SMEGESQPVK141MFDRHSSLAG
151-200151CQIINYRTDA161KQKWLLLTGI171SAQQNRVVGA181MQLYSVDRKV191SQPIEGHAAS
201-250201FAQFKMEGNA211EESTLFCFAV221RGQAGGKLHI231IEVGTPPTGN241QPFPKKAVDV
251-300251FFPPEAQNDF261PVAMQISEKH271DVVFLITKYG281YIHLYDLETG291TCIYMNRISG
301-350301ETIFVTAPHE311ATAGIIGVNR321KGQVLSVCVE331EENIIPYITN341VLQNPDLALR
351-400351MAVRNNLAGA361EELFARKFNA371LFAQGNYSEA381AKVAANAPKG391ILRTPDTIRR
401-450401FQSVPAQPGQ411TSPLLQYFGI421LLDQGQLNKY431ESLELCRPVL441QQGRKQLLEK
451-500451WLKEDKLECS461EELGDLVKSV471DPTLALSVYL481RANVPNKVIQ491CFAETGQVQK
501-550501IVLYAKKVGY511TPDWIFLLRN521VMRISPDQGQ531QFAQMLVQDE541EPLADITQIV
551-600551DVFMEYNLIQ561QCTAFLLDAL571KNNRPSEGPL581QTRLLEMNLM591HAPQVADAIL
601-650601GNQMFTHYDR611AHIAQLCEKA621GLLQRALEHF631TDLYDIKRAV641VHTHLLNPEW
651-700651LVNYFGSLSV661EDSLECLRAM671LSANIRQNLQ681ICVQVASKYH691EQLSTQSLIE
701-750701LFESFKSFEG711LFYFLGSIVN721FSQDPDVHFK731YIQAACKTGQ741IKEVERICRE
751-800751SNCYDPERVK761NFLKDMYQEA771KLTDQLPLII781VCDRFDFVHD791LVLYLYRNNL
801-850801QKYIEIYVQK811VNPSRLPVVI821GGLLDVDCSE831DVIKNLILVV841RGQFSTDELV
851-900851AEVEKRNRLK861LLLPWLEARI871HEGCEEPATH881NALAKIYIDS891NNNPERFLRE
901-950901NPYYDSRVVG911KYCEKRDPHL921ACVAYERGQC931DLELINVCNE941NSLFKSLSRY
951-1000951LVRRKDPELW961GSVLLESNPY971RRPLIDQVVQ981TALSETQDPE991EVSVTVKAFM
1001-10501001TADLPNELIE1011LLEKIVLDNS1021VFSEHRNLQN1031LLILTAIKAD1041RTRVMEYINR
1051-11001051LDNYDAPDIA1061NIAISNELFE1071EAFAIFRKFD1081VNTSAVQVLI1091EHIGNLDRAY
1101-11501101EFAERCNEPA1111VWSQLAKAQL1121QKGMVKEAID1131SYIKADDPSS1141YMEVVQAANT
1151-12001151SGNWEELVKY1161LQMARKKARE1171SYVETELIFA1181LAKTNRLAEL1191EEFINGPNNA
1201-12501201HIQQVGDRCY1211DEKMYDAAKL1221LYNNVSNFGR1231LASTLVHLGE1241YQAAVDGARK
1251-13001251ANSTRTWKEV1261CFACVDGKEF1271RLAQMCGLHI1281VVHADELEEL1291INYYQDRGYF
1301-13501301EELITMLEAA1311LGLERAHMGM1321FTELAILYSK1331FKPQKMREHL1341ELFWSRVNIP
1351-14001351KVLRAAEQAH1361LWAELVFLYD1371KYEEYDNAII1381TMMNHPTDAW1391KEGQFKDIIT
1401-14501401KVANVELYYR1411AIQFYLEFKP1421LLLNDLLMVL1431SPRLDHTRAV1441NYFSKVKQLP
1451-15001451LVKPYLRSVQ1461NHNNKSVNES1471LNNLFITEED1481YQALRTSIDA1491YDNFDNISLA
1501-15501501QRLEKHELIE1511FRRIAAYLFK1521GNNRWKQSVE1531LCKKDSLYKD1541AMQYASESKD
1551-16001551TELAEELLQW1561FLQEEKRECF1571GACLFTCYDL1581LRPDVVLETA1591WRHNIMDFAM
1601-16501601PYFIQVMKEY1611LTKVDKLDAS1621ESLRKEEEQA1631TETQPIVYGQ1641PQLMLTAGPS
1651-16791651VAVPPQAPFG1661YGYTAPPYGQ1671PQPGFGYSM
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 39 | CLATHRIN HEAVY CHAIN RELATED Clathrin heavy chain, N-terminal Clathrin, heavy chain, propeller repeat | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.87
|
|
| 151 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.89
Deep-Palm: 0.73
|
|
| 217 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.66
Deep-Palm: 0.87
|
|
| 292 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.15
|
|
| 328 | - | - | - |
Deep-Palm: 0.86
|
|
| 436 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.86
Deep-Palm: 0.98
|
|
| 459 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.98
|
|
| 491 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.88
Deep-Palm: 0.92
|
|
| 562 | - | - | - |
Deep-Palm: 0.48
|
|
| 617 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.82
Deep-Palm: 0.85
|
|
| 666 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.94
|
|
| 682 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.82
|
|
| 736 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.56
|
|
| 748 | - | - | - |
Deep-Palm: 0.49
|
|
| 753 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.59
|
|
| 782 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.80
Deep-Palm: 0.76
|
|
| 828 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.96
|
|
| 874 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.98
|
|
| 913 | - | - | - |
Deep-Palm: 0.89
|
|
| 922 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.90
|
|
| 930 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
Deep-Palm: 0.41
|
|
| 938 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.86
Deep-Palm: 0.91
|
|
| 1106 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
Deep-Palm: 0.66
|
|
| 1209 | - | - | - |
Deep-Palm: 0.08
|
|
| 1261 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.84
Deep-Palm: 0.76
|
|
| 1264 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.50
|
|
| 1276 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.86
|
|
| 1532 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.70
|
|
| 1569 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.79
|
|
| 1573 | - | - | - |
Deep-Palm: 0.71
|
|
| 1577 | - | - | - |
Deep-Palm: 0.94
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
PC3
Specificity: 0.364
4/4 (100.0%)
2
Jurkat T cell
Specificity: 0.182
2/2 (100.0%)
1
frontal cortex
Specificity: 0.091
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.364
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 176 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 294 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 305 | V → Cfs*6 | 0.002976 | INS | Frame Shift Ins | KIRC |
| 328 | C → Ffs*9 | 0.002747 | DEL | Frame Shift Del | LIHC |
| 354 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 655 | F → C | 0.001969 | SNP | Missense Mutation | LGG |
| 895 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 903 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 903 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 923 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1189 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1210 | M → Cfs*52 | 0.002506 | DEL | Frame Shift Del | COAD |
| 1289 | Y → C | 0.002294 | SNP | Missense Mutation | OV |
| 1544 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| ? | ? → ? | 0.001014 | SNP | Missense Mutation | BRCA |