Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A0A8V8TRE8 | CLTC | Clathrin heavy chain | Homo sapiens (Human) | 1617 aa |
Protein Details: A0A8V8TRE8 (CLTC)
Protein Information
| Accession | A0A8V8TRE8 |
|---|---|
| Protein Names | Clathrin heavy chain |
| Gene Symbol | CLTC |
| Organism | Homo sapiens (Human) |
| Length | 1617 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 21076176 26876311 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAQILPIRFQ11EHLQLQNLGI21NPANIGFSTL31TMESDKFICI41REKVGEQAQV
51-10051VIIDMNDPSN61PIRRPISADS71AIMNPASKVI81ALKAGKTLQI91FNIEMKSKMK
101-150101AHTMTDDVTF111WKWISLNTVA121LVTDNAVYHW131SMEGESQPVK141MFDRHSSLAG
151-200151CQIINYRTDA161KQKWLLLTGI171SAQQNRVVGA181MQLYSVDRKV191SQPIEGHAAS
201-250201FAQFKMEGNA211EESTLFCFAV221RGQAGGKLHI231IEVGTPPTGN241QPFPKKAVDV
251-300251FFPPEAQNDF261PVAMQVLSVC271VEEENIIPYI281TNVLQNPDLA291LRMAVRNNLA
301-350301GAEELFARKF311NALFAQGNYS321EAAKVAANAP331KGILRTPDTI341RRFQSVPAQP
351-400351GQTSPLLQYF361GILLDQGQLN371KYESLELCRP381VLQQGRKQLL391EKWLKEDKLE
401-450401CSEELGDLVK411SVDPTLALSV421YLRANVPNKV431IQCFAETGQV441QKIVLYAKKV
451-500451GYTPDWIFLL461RNVMRISPDQ471GQQFAQMLVQ481DEEPLADITQ491IVDVFMEYNL
501-550501IQQCTAFLLD511ALKNNRPSEG521PLQTRLLEMN531LMHAPQVADA541ILGNQMFTHY
551-600551DRAHIAQLCE561KAGLLQRALE571HFTDLYDIKR581AVVHTHLLNP591EWLVNYFGSL
601-650601SVEDSLECLR611AMLSANIRQN621LQICVQVASK631YHEQLSTQSL641IELFESFKSF
651-700651EGLFYFLGSI661VNFSQDPDVH671FKYIQAACKT681GQIKEVERIC691RESNCYDPER
701-750701VKNFLKEAKL711TDQLPLIIVC721DRFDFVHDLV731LYLYRNNLQK741YIEIYVQKVN
751-800751PSRLPVVIGG761LLDVDCSEDV771IKNLILVVRG781QFSTDELVAE791VEKRNRLKLL
801-850801LPWLEARIHE811GCEEPATHNA821LAKIYIDSNN831NPERFLRENP841YYDSRVVGKY
851-900851CEKRDPHLAC861VAYERGQCDL871ELINVCNENS881LFKSLSRYLV891RRKDPELWGS
901-950901VLLESNPYRR911PLIDQVVQTA921LSETQDPEEV931SVTVKAFMTA941DLPNELIELL
951-1000951EKIVLDNSVF961SEHRNLQNLL971ILTAIKADRT981RVMEYINRLD991NYDAPDIANI
1001-10501001AISNELFEEA1011FAIFRKFDVN1021TSAVQVLIEH1031IGNLDRAYEF1041AERCNEPAVW
1051-11001051SQLAKAQLQK1061GMVKEAIDSY1071IKADDPSSYM1081EVVQAANTSG1091NWEELVKYLQ
1101-11501101MARKKARESY1111VETELIFALA1121KTNRLAELEE1131FINGPNNAHI1141QQVGDRCYDE
1151-12001151KMYDAAKLLY1161NNVSNFGRLA1171STLVHLGEYQ1181AAVDGARKAN1191STRTWKEVCF
1201-12501201ACVDGKEFRL1211AQMCGLHIVV1221HADELEELIN1231YYQDRGYFEE1241LITMLEAALG
1251-13001251LERAHMGMFT1261ELAILYSKFK1271PQKMREHLEL1281FWSRVNIPKV1291LRAAEQAHLW
1301-13501301AELVFLYDKY1311EEYDNAIITM1321MNHPTDAWKE1331GQFKDIITKV1341ANVELYYRAI
1351-14001351QFYLEFKPLL1361LNDLLMVLSP1371RLDHTRAVNY1381FSKVKQLPLV1391KPYLRSVQNH
1401-14501401NNKSVNESLN1411NLFITEEDYQ1421ALRTSIDAYD1431NFDNISLAQR1441LEKHELIEFR
1451-15001451RIAAYLFKGN1461NRWKQSVELC1471KKDSLYKDAM1481QYASESKDTE1491LAEELLQWFL
1501-15501501QEEKRECFGA1511CLFTCYDLLR1521PDVVLETAWR1531HNIMDFAMPY1541FIQVMKEYLT
1551-16001551KVDKLDASES1561LRKEEEQATE1571TQPIVYGQPQ1581LMLTAGPSVA1591VPPQAPFGYG
1601-16171601YTAPPYGQPQ1611PGFGYSM
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 39 | CLATHRIN HEAVY CHAIN RELATED Clathrin heavy chain, N-terminal Clathrin, heavy chain, propeller repeat | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.87
|
|
| 151 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.89
Deep-Palm: 0.73
|
|
| 217 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.66
Deep-Palm: 0.87
|
|
| 270 | - | - | - |
Deep-Palm: 0.17
|
|
| 378 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.86
Deep-Palm: 0.98
|
|
| 401 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.98
|
|
| 433 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.88
Deep-Palm: 0.92
|
|
| 504 | - | - | - |
Deep-Palm: 0.48
|
|
| 559 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.82
Deep-Palm: 0.85
|
|
| 608 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.94
|
|
| 624 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.82
|
|
| 678 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.56
|
|
| 690 | - | - | - |
Deep-Palm: 0.49
|
|
| 695 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.95
|
|
| 720 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.80
Deep-Palm: 0.96
|
|
| 766 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.96
|
|
| 812 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.98
|
|
| 851 | - | - | - |
Deep-Palm: 0.89
|
|
| 860 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.90
|
|
| 868 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
Deep-Palm: 0.41
|
|
| 876 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.86
Deep-Palm: 0.91
|
|
| 1044 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
Deep-Palm: 0.66
|
|
| 1147 | - | - | - |
Deep-Palm: 0.08
|
|
| 1199 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.84
Deep-Palm: 0.76
|
|
| 1202 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.50
|
|
| 1214 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.86
|
|
| 1470 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.70
|
|
| 1507 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.79
|
|
| 1511 | - | - | - |
Deep-Palm: 0.71
|
|
| 1515 | - | - | - |
Deep-Palm: 0.94
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
PC3
Specificity: 0.364
4/4 (100.0%)
2
Jurkat T cell
Specificity: 0.182
2/2 (100.0%)
1
frontal cortex
Specificity: 0.091
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.364
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 176 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 294 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 305 | V → Cfs*6 | 0.002976 | INS | Frame Shift Ins | KIRC |
| 328 | C → Ffs*9 | 0.002747 | DEL | Frame Shift Del | LIHC |
| 354 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 655 | F → C | 0.001969 | SNP | Missense Mutation | LGG |
| 895 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 903 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 903 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 923 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1189 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1210 | M → Cfs*52 | 0.002506 | DEL | Frame Shift Del | COAD |
| 1289 | Y → C | 0.002294 | SNP | Missense Mutation | OV |
| 1544 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| ? | ? → ? | 0.001014 | SNP | Missense Mutation | BRCA |