Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A0A8V8TRF0 | CLTC | Clathrin heavy chain | Homo sapiens (Human) | 1676 aa |
Protein Details: A0A8V8TRF0 (CLTC)
Protein Information
| Accession | A0A8V8TRF0 |
|---|---|
| Protein Names | Clathrin heavy chain |
| Gene Symbol | CLTC |
| Organism | Homo sapiens (Human) |
| Length | 1676 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 21076176 26876311 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAQILPIRFQ11EHLQLQNLGI21NPANIGFSTL31TMESDKFICI41REKVGEQAQV
51-10051VIIDMNDPSN61PIRRPISADS71AIMNPASKVI81ALKDAGKTLQ91IFNIEMKSKM
101-150101KAHTMTDDVT111FWKWISLNTV121ALVTDNAVYH131WSMEGESQPV141KMFDRHSSLA
151-200151GCQIINYRTD161AKQKWLLLTG171ISAQQNRVVG181AMQLYSVDRK191VSQPIEGHAA
201-250201SFAQFKMEGN211AEESTLFCFA221VRGQAGGKLH231IIEVGTPPTG241NQPFPKKAVD
251-300251VFFPPEAQND261FPVAMQISEK271HDVVFLITKY281GYIHLYDLET291GTCIYMNRIS
301-350301GETIFVTAPH311EATAGIIGVN321RKGQVLSVCV331EEENIIPYIT341NVLQNPDLAL
351-400351RMAVRNNLAG361AEELFARKFN371ALFAQGNYSE381AAKVAANAPK391GILRTPDTIR
401-450401RFQSVPAQPG411QTSPLLQYFG421ILLDQGQLNK431YESLELCRPV441LQQGRKQLLE
451-500451KWLKEDKLEC461SEELGDLVKS471VDPTLALSVY481LRANVPNKVI491QCFAETGQVQ
501-550501KIVLYAKKVG511YTPDWIFLLR521NVMRISPDQG531QQFAQMLVQD541EEPLADITQI
551-600551VDVFMEYNLI561QQCTAFLLDA571LKNNRPSEGP581LQTRLLEMNL591MHAPQVADAI
601-650601LGNQMFTHYD611RAHIAQLCEK621AGLLQRALEH631FTDLYDIKRA641VVHTHLLNPE
651-700651WLVNYFGSLS661VEDSLECLRA671MLSANIRQNL681QICVQVASKY691HEQLSTQSLI
701-750701ELFESFKSFE711GLFYFLGSIV721NFSQDPDVHF731KYIQAACKTG741QIKEVERICR
751-800751ESNCYDPERV761KNFLKEAKLT771DQLPLIIVCD781RFDFVHDLVL791YLYRNNLQKY
801-850801IEIYVQKVNP811SRLPVVIGGL821LDVDCSEDVI831KNLILVVRGQ841FSTDELVAEV
851-900851EKRNRLKLLL861PWLEARIHEG871CEEPATHNAL881AKIYIDSNNN891PERFLRENPY
901-950901YDSRVVGKYC911EKRDPHLACV921AYERGQCDLE931LINVCNENSL941FKSLSRYLVR
951-1000951RKDPELWGSV961LLESNPYRRP971LIDQVVQTAL981SETQDPEEVS991VTVKAFMTAD
1001-10501001LPNELIELLE1011KIVLDNSVFS1021EHRNLQNLLI1031LTAIKADRTR1041VMEYINRLDN
1051-11001051YDAPDIANIA1061ISNELFEEAF1071AIFRKFDVNT1081SAVQVLIEHI1091GNLDRAYEFA
1101-11501101ERCNEPAVWS1111QLAKAQLQKG1121MVKEAIDSYI1131KADDPSSYME1141VVQAANTSGN
1151-12001151WEELVKYLQM1161ARKKARESYV1171ETELIFALAK1181TNRLAELEEF1191INGPNNAHIQ
1201-12501201QVGDRCYDEK1211MYDAAKLLYN1221NVSNFGRLAS1231TLVHLGEYQA1241AVDGARKANS
1251-13001251TRTWKEVCFA1261CVDGKEFRLA1271QMCGLHIVVH1281ADELEELINY1291YQDRGYFEEL
1301-13501301ITMLEAALGL1311ERAHMGMFTE1321LAILYSKFKP1331QKMREHLELF1341WSRVNIPKVL
1351-14001351RAAEQAHLWA1361ELVFLYDKYE1371EYDNAIITMM1381NHPTDAWKEG1391QFKDIITKVA
1401-14501401NVELYYRAIQ1411FYLEFKPLLL1421NDLLMVLSPR1431LDHTRAVNYF1441SKVKQLPLVK
1451-15001451PYLRSVQNHN1461NKSVNESLNN1471LFITEEDYQA1481LRTSIDAYDN1491FDNISLAQRL
1501-15501501EKHELIEFRR1511IAAYLFKGNN1521RWKQSVELCK1531KDSLYKDAMQ1541YASESKDTEL
1551-16001551AEELLQWFLQ1561EEKRECFGAC1571LFTCYDLLRP1581DVVLETAWRH1591NIMDFAMPYF
1601-16501601IQVMKEYLTK1611VDKLDASESL1621RKEEEQATET1631QPIVYGQPQL1641MLTAGPSVAV
1651-16761651PPQAPFGYGY1661TAPPYGQPQP1671GFGYSM
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 39 | CLATHRIN HEAVY CHAIN RELATED Clathrin heavy chain, N-terminal Clathrin, heavy chain, propeller repeat | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.87
|
|
| 152 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.89
Deep-Palm: 0.73
|
|
| 218 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.66
Deep-Palm: 0.87
|
|
| 293 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.15
|
|
| 329 | - | - | - |
Deep-Palm: 0.86
|
|
| 437 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.86
Deep-Palm: 0.98
|
|
| 460 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.98
|
|
| 492 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.88
Deep-Palm: 0.92
|
|
| 563 | - | - | - |
Deep-Palm: 0.48
|
|
| 618 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.82
Deep-Palm: 0.85
|
|
| 667 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.94
|
|
| 683 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.82
|
|
| 737 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.56
|
|
| 749 | - | - | - |
Deep-Palm: 0.49
|
|
| 754 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.95
|
|
| 779 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.80
Deep-Palm: 0.96
|
|
| 825 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.96
|
|
| 871 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.98
|
|
| 910 | - | - | - |
Deep-Palm: 0.89
|
|
| 919 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.90
|
|
| 927 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
Deep-Palm: 0.41
|
|
| 935 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.86
Deep-Palm: 0.91
|
|
| 1103 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
Deep-Palm: 0.66
|
|
| 1206 | - | - | - |
Deep-Palm: 0.08
|
|
| 1258 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.84
Deep-Palm: 0.76
|
|
| 1261 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.50
|
|
| 1273 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.86
|
|
| 1529 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.70
|
|
| 1566 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.79
|
|
| 1570 | - | - | - |
Deep-Palm: 0.71
|
|
| 1574 | - | - | - |
Deep-Palm: 0.94
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
PC3
Specificity: 0.364
4/4 (100.0%)
2
Jurkat T cell
Specificity: 0.182
2/2 (100.0%)
1
frontal cortex
Specificity: 0.091
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.364
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 176 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 294 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 305 | V → Cfs*6 | 0.002976 | INS | Frame Shift Ins | KIRC |
| 328 | C → Ffs*9 | 0.002747 | DEL | Frame Shift Del | LIHC |
| 354 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 655 | F → C | 0.001969 | SNP | Missense Mutation | LGG |
| 895 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 903 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 903 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 923 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1189 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1210 | M → Cfs*52 | 0.002506 | DEL | Frame Shift Del | COAD |
| 1289 | Y → C | 0.002294 | SNP | Missense Mutation | OV |
| 1544 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| ? | ? → ? | 0.001014 | SNP | Missense Mutation | BRCA |