Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A0AAQ5BHN6 | CLTC | Clathrin heavy chain | Homo sapiens (Human) | 1644 aa |
Protein Details: A0AAQ5BHN6 (CLTC)
Protein Information
| Accession | A0AAQ5BHN6 |
|---|---|
| Protein Names | Clathrin heavy chain |
| Gene Symbol | CLTC |
| Organism | Homo sapiens (Human) |
| Length | 1644 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 21076176 26876311 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MESDKFICIR11EKVGEQAQVV21IIDMNDPSNP31IRRPISADSA41IMNPASKVIA
51-10051LKAGKTLQIF61NIEMKSKMKA71HTMTDDVTFW81KWISLNTVAL91VTDNAVYHWS
101-150101MEGESQPVKM111FDRHSSLAGC121QIINYRTDAK131QKWLLLTGIS141AQQNRVVGAM
151-200151QLYSVDRKVS161QPIEGHAASF171AQFKMEGNAE181ESTLFCFAVR191GQAGGKLHII
201-250201EVGTPPTGNQ211PFPKKAVDVF221FPPEAQNDFP231VAMQISEKHD241VVFLITKYGY
251-300251IHLYDLETGT261CIYMNRISGE271TIFVTAPHEA281TAGIIGVNRK291GQVLSVCVEE
301-350301ENIIPYITNV311LQNPDLALRM321AVRNNLAGAE331ELFARKFNAL341FAQGNYSEAA
351-400351KVAANAPKGI361LRTPDTIRRF371QSVPAQPGQT381SPLLQYFGIL391LDQGQLNKYE
401-450401SLELCRPVLQ411QGRKQLLEKW421LKEDKLECSE431ELGDLVKSVD441PTLALSVYLR
451-500451ANVPNKVIQC461FAETGQVQKI471VLYAKKVGYT481PDWIFLLRNV491MRISPDQGQQ
501-550501FAQMLVQDEE511PLADITQIVD521VFMEYNLIQQ531CTAFLLDALK541NNRPSEGPLQ
551-600551TRLLEMNLMH561APQVADAILG571NQMFTHYDRA581HIAQLCEKAG591LLQRALEHFT
601-650601DLYDIKRAVV611HTHLLNPEWL621VNYFGSLSVE631DSLECLRAML641SANIRQNLQI
651-700651CVQVASKYHE661QLSTQSLIEL671FESFKSFEGL681FYFLGSIVNF691SQDPDVHFKY
701-750701IQAACKTGQI711KEVERICRES721NCYDPERVKN731FLKEAKLTDQ741LPLIIVCDRF
751-800751DFVHDLVLYL761YRNNLQKYIE771IYVQKVNPSR781LPVVIGGLLD791VDCSEDVIKN
801-850801LILVVRGQFS811TDELVAEVEK821RNRLKLLLPW831LEARIHEGCE841EPATHNALAK
851-900851IYIDSNNNPE861RFLRENPYYD871SRVVGKYCEK881RDPHLACVAY891ERGQCDLELI
901-950901NVCNENSLFK911SLSRYLVRRK921DPELWGSVLL931ESNPYRRPLI941DQVVQTALSE
951-1000951TQDPEEVSVT961VKAFMTADLP971NELIELLEKI981VLDNSVFSEH991RNLQNLLILT
1001-10501001AIKADRTRVM1011EYINRLDNYD1021APDIANIAIS1031NELFEEAFAI1041FRKFDVNTSA
1051-11001051VQVLIEHIGN1061LDRAYEFAER1071CNEPAVWSQL1081AKAQLQKGMV1091KEAIDSYIKA
1101-11501101DDPSSYMEVV1111QAANTSGNWE1121ELVKYLQMAR1131KKARESYVET1141ELIFALAKTN
1151-12001151RLAELEEFIN1161GPNNAHIQQV1171GDRCYDEKMY1181DAAKLLYNNV1191SNFGRLASTL
1201-12501201VHLGEYQAAV1211DGARKANSTR1221TWKEVCFACV1231DGKEFRLAQM1241CGLHIVVHAD
1251-13001251ELEELINYYQ1261DRGYFEELIT1271MLEAALGLER1281AHMGMFTELA1291ILYSKFKPQK
1301-13501301MREHLELFWS1311RVNIPKVLRA1321AEQAHLWAEL1331VFLYDKYEEY1341DNAIITMMNH
1351-14001351PTDAWKEGQF1361KDIITKVANV1371ELYYRAIQFY1381LEFKPLLLND1391LLMVLSPRLD
1401-14501401HTRAVNYFSK1411VKQLPLVKPY1421LRSVQNHNNK1431SVNESLNNLF1441ITEEDYQALR
1451-15001451TSIDAYDNFD1461NISLAQRLEK1471HELIEFRRIA1481AYLFKGNNRW1491KQSVELCKKD
1501-15501501SLYKDAMQYA1511SESKDTELAE1521ELLQWFLQEE1531KRECFGACLF1541TCYDLLRPDV
1551-16001551VLETAWRHNI1561MDFAMPYFIQ1571VMKEYLTKVD1581KLDASESLRK1591EEEQATETQP
1601-16441601IVYGQPQLML1611TAGPSVAVPP1621QAPFGYGYTA1631PPYGQPQPGF1641GYSM
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 8 | Clathrin heavy chain, N-terminal Clathrin, heavy chain, propeller repeat | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.04
|
|
| 120 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.89
Deep-Palm: 0.73
|
|
| 186 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.66
Deep-Palm: 0.87
|
|
| 261 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.15
|
|
| 297 | - | - | - |
Deep-Palm: 0.86
|
|
| 405 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.86
Deep-Palm: 0.98
|
|
| 428 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.98
|
|
| 460 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.88
Deep-Palm: 0.92
|
|
| 531 | - | - | - |
Deep-Palm: 0.48
|
|
| 586 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.82
Deep-Palm: 0.85
|
|
| 635 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.94
|
|
| 651 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.82
|
|
| 705 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.56
|
|
| 717 | - | - | - |
Deep-Palm: 0.49
|
|
| 722 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.95
|
|
| 747 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.80
Deep-Palm: 0.96
|
|
| 793 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.96
|
|
| 839 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.98
|
|
| 878 | - | - | - |
Deep-Palm: 0.89
|
|
| 887 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.90
|
|
| 895 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
Deep-Palm: 0.41
|
|
| 903 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.86
Deep-Palm: 0.91
|
|
| 1071 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
Deep-Palm: 0.66
|
|
| 1174 | - | - | - |
Deep-Palm: 0.08
|
|
| 1226 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.84
Deep-Palm: 0.76
|
|
| 1229 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.50
|
|
| 1241 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.86
|
|
| 1497 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.70
|
|
| 1534 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.79
|
|
| 1538 | - | - | - |
Deep-Palm: 0.71
|
|
| 1542 | - | - | - |
Deep-Palm: 0.94
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
PC3
Specificity: 0.364
4/4 (100.0%)
2
Jurkat T cell
Specificity: 0.182
2/2 (100.0%)
1
frontal cortex
Specificity: 0.091
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.364
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 176 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 294 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 305 | V → Cfs*6 | 0.002976 | INS | Frame Shift Ins | KIRC |
| 328 | C → Ffs*9 | 0.002747 | DEL | Frame Shift Del | LIHC |
| 354 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 655 | F → C | 0.001969 | SNP | Missense Mutation | LGG |
| 895 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 903 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 903 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 923 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1189 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1210 | M → Cfs*52 | 0.002506 | DEL | Frame Shift Del | COAD |
| 1289 | Y → C | 0.002294 | SNP | Missense Mutation | OV |
| 1544 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| ? | ? → ? | 0.001014 | SNP | Missense Mutation | BRCA |