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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
A0AAQ5BHT1 CLTC Clathrin heavy chain Homo sapiens (Human) 426 aa

Protein Details: A0AAQ5BHT1 (CLTC)

Protein Information
AccessionA0AAQ5BHT1
Protein NamesClathrin heavy chain
Gene SymbolCLTC
OrganismHomo sapiens (Human)
Length426 aa
IsoformsNo isoforms
Related PMIDs 19137006 21076176 26876311 32944167
Database SourcesNo database sources
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MAQILPIRFQ11EHLQLQNLGI21NPANIGFSTL31TMESDKFICI41REKVGEQAQV
51-10051VIIDMNDPSN61PIRRPISADS71AIMNPASKVI81ALKAGKTLQI91FNIEMKSKMK
101-150101AHTMTDDVTF111WKWISLNTVA121LVTDNAVYHW131SMEGESQPVK141MFDRHSSLAG
151-200151CQIINYRTDA161KQKWLLLTGI171SAQQNRVVGA181MQLYSVDRKV191SQPIEGHAAS
201-250201FAQFKMEGNA211EESTLFCFAV221RGQAGGKLHI231IEVGTPPTGN241QPFPKKAVDV
251-300251FFPPEAQNDF261PVAMQISEKH271DVVFLITKYG281YIHLYDLETG291TCIYMNRISG
301-350301ETIFVTAPHE311ATAGIIGVNR321KGQVLSVCVE331EENIIPYITN341VLQNPDLALR
351-400351MAVRNNLAGA361EELFARKFNA371LFAQGNYSEA381AKVAANAPKT391LSVGSRVSQP
401-426401SQVKLLLYFS411TLVSFWTRDS421STNTNP
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
39 CLATHRIN HEAVY CHAIN RELATED Clathrin heavy chain, N-terminal Clathrin, heavy chain, propeller repeat - -
GPS-Palm: 0.73
Deep-Palm: 0.87
151 - -
cerebral cortex (36430497)
GPS-Palm: 0.89
Deep-Palm: 0.73
217 - -
cerebral cortex (36430497)
GPS-Palm: 0.66
Deep-Palm: 0.87
292 - - -
GPS-Palm: 0.73
Deep-Palm: 0.15
328 - - -
Deep-Palm: 0.86
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
PC3
Specificity: 0.571
4/4 (100.0%)
2
Jurkat T cell
Specificity: 0.286
2/2 (100.0%)
1
frontal cortex
Specificity: 0.143
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
176 R → C 0.007299 SNP Missense Mutation READ
294 Y → C 0.001887 SNP Missense Mutation UCEC
305 V → Cfs*6 0.002976 INS Frame Shift Ins KIRC
328 C → Ffs*9 0.002747 DEL Frame Shift Del LIHC
354 R → C 0.002506 SNP Missense Mutation COAD
655 F → C 0.001969 SNP Missense Mutation LGG
895 R → C 0.002506 SNP Missense Mutation COAD
903 R → C 0.002506 SNP Missense Mutation COAD
903 R → C 0.001887 SNP Missense Mutation UCEC
923 R → C 0.001887 SNP Missense Mutation UCEC
1189 F → C 0.001887 SNP Missense Mutation UCEC
1210 M → Cfs*52 0.002506 DEL Frame Shift Del COAD
1289 Y → C 0.002294 SNP Missense Mutation OV
1544 S → C 0.001764 SNP Missense Mutation LUAD
? ? → ? 0.001014 SNP Missense Mutation BRCA