Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A0AAQ5BHU5 | CLTC | Clathrin heavy chain | Homo sapiens (Human) | 1668 aa |
Protein Details: A0AAQ5BHU5 (CLTC)
Protein Information
| Accession | A0AAQ5BHU5 |
|---|---|
| Protein Names | Clathrin heavy chain |
| Gene Symbol | CLTC |
| Organism | Homo sapiens (Human) |
| Length | 1668 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 21076176 26876311 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAQILPIRFQ11EHLQLQNLGI21NPANIGFSTL31TMESDKFICI41REKVGEQAQV
51-10051VIIDMNDPSN61PIRRPISADS71AIMNPASKVI81ALKAGKTLQI91FNIEMKSKMK
101-150101AHTMTDDVTF111WKWISLNTVA121LVTDNAVYHW131SMEGESQPVK141MFDRHSSLAG
151-200151CQIINYRTDA161KQKWLLLTGI171SAQQNRVVGA181MQLYSVDRKV191SQPIEGHAAS
201-250201FAQFKMEGNA211EESTLFCFAV221RGQAGGKLHI231IEVGTPPTGN241QPFPKKAVDV
251-300251FFPPEAQNDF261PVAMQISEKH271DVVFLITKYG281YIHLYDLETG291TCIYMNRISG
301-350301ETIFVTAPHE311ATAGIIGVNR321KGQVLSVCVE331EENIIPYITN341VLQNPDLALR
351-400351MAVRNNLAGA361EELFARKFNA371LFAQGNYSEA381AKGILRTPDT391IRRFQSVPAQ
401-450401PGQTSPLLQY411FGILLDQGQL421NKYESLELCR431PVLQQGRKQL441LEKWLKEDKL
451-500451ECSEELGDLV461KSVDPTLALS471VYLRANVPNK481VIQCFAETGQ491VQKIVLYAKK
501-550501VGYTPDWIFL511LRNVMRISPD521QGQQFAQMLV531QDEEPLADIT541QIVDVFMEYN
551-600551LIQQCTAFLL561DALKNNRPSE571GPLQTRLLEM581NLMHAPQVAD591AILGNQMFTH
601-650601YDRAHIAQLC611EKAGLLQRAL621EHFTDLYDIK631RAVVHTHLLN641PEWLVNYFGS
651-700651LSVEDSLECL661RAMLSANIRQ671NLQICVQVAS681KYHEQLSTQS691LIELFESFKS
701-750701FEGLFYFLGS711IVNFSQDPDV721HFKYIQAACK731TGQIKEVERI741CRESNCYDPE
751-800751RVKNFLKEAK761LTDQLPLIIV771CDRFDFVHDL781VLYLYRNNLQ791KYIEIYVQKV
801-850801NPSRLPVVIG811GLLDVDCSED821VIKNLILVVR831GQFSTDELVA841EVEKRNRLKL
851-900851LLPWLEARIH861EGCEEPATHN871ALAKIYIDSN881NNPERFLREN891PYYDSRVVGK
901-950901YCEKRDPHLA911CVAYERGQCD921LELINVCNEN931SLFKSLSRYL941VRRKDPELWG
951-1000951SVLLESNPYR961RPLIDQVVQT971ALSETQDPEE981VSVTVKAFMT991ADLPNELIEL
1001-10501001LEKIVLDNSV1011FSEHRNLQNL1021LILTAIKADR1031TRVMEYINRL1041DNYDAPDIAN
1051-11001051IAISNELFEE1061AFAIFRKFDV1071NTSAVQVLIE1081HIGNLDRAYE1091FAERCNEPAV
1101-11501101WSQLAKAQLQ1111KGMVKEAIDS1121YIKADDPSSY1131MEVVQAANTS1141GNWEELVKYL
1151-12001151QMARKKARES1161YVETELIFAL1171AKTNRLAELE1181EFINGPNNAH1191IQQVGDRCYD
1201-12501201EKMYDAAKLL1211YNNVSNFGRL1221ASTLVHLGEY1231QAAVDGARKA1241NSTRTWKEVC
1251-13001251FACVDGKEFR1261LAQMCGLHIV1271VHADELEELI1281NYYQDRGYFE1291ELITMLEAAL
1301-13501301GLERAHMGMF1311TELAILYSKF1321KPQKMREHLE1331LFWSRVNIPK1341VLRAAEQAHL
1351-14001351WAELVFLYDK1361YEEYDNAIIT1371MMNHPTDAWK1381EGQFKDIITK1391VANVELYYRA
1401-14501401IQFYLEFKPL1411LLNDLLMVLS1421PRLDHTRAVN1431YFSKVKQLPL1441VKPYLRSVQN
1451-15001451HNNKSVNESL1461NNLFITEEDY1471QALRTSIDAY1481DNFDNISLAQ1491RLEKHELIEF
1501-15501501RRIAAYLFKG1511NNRWKQSVEL1521CKKDSLYKDA1531MQYASESKDT1541ELAEELLQWF
1551-16001551LQEEKRECFG1561ACLFTCYDLL1571RPDVVLETAW1581RHNIMDFAMP1591YFIQVMKEYL
1601-16501601TKVDKLDASE1611SLRKEEEQAT1621ETQPIVYGQP1631QLMLTAGPSV1641AVPPQAPFGY
1651-16681651GYTAPPYGQP1661QPGFGYSM
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 39 | CLATHRIN HEAVY CHAIN RELATED Clathrin heavy chain, N-terminal Clathrin, heavy chain, propeller repeat | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.87
|
|
| 151 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.89
Deep-Palm: 0.73
|
|
| 217 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.66
Deep-Palm: 0.87
|
|
| 292 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.15
|
|
| 328 | - | - | - |
Deep-Palm: 0.86
|
|
| 429 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.86
Deep-Palm: 0.98
|
|
| 452 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.98
|
|
| 484 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.88
Deep-Palm: 0.92
|
|
| 555 | - | - | - |
Deep-Palm: 0.48
|
|
| 610 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.82
Deep-Palm: 0.85
|
|
| 659 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.94
|
|
| 675 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.82
|
|
| 729 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.56
|
|
| 741 | - | - | - |
Deep-Palm: 0.49
|
|
| 746 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.95
|
|
| 771 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.80
Deep-Palm: 0.96
|
|
| 817 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.96
|
|
| 863 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.98
|
|
| 902 | - | - | - |
Deep-Palm: 0.89
|
|
| 911 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.90
|
|
| 919 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
Deep-Palm: 0.41
|
|
| 927 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.86
Deep-Palm: 0.91
|
|
| 1095 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
Deep-Palm: 0.66
|
|
| 1198 | - | - | - |
Deep-Palm: 0.08
|
|
| 1250 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.84
Deep-Palm: 0.76
|
|
| 1253 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.50
|
|
| 1265 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.86
|
|
| 1521 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.70
|
|
| 1558 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.79
|
|
| 1562 | - | - | - |
Deep-Palm: 0.71
|
|
| 1566 | - | - | - |
Deep-Palm: 0.94
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
PC3
Specificity: 0.364
4/4 (100.0%)
2
Jurkat T cell
Specificity: 0.182
2/2 (100.0%)
1
frontal cortex
Specificity: 0.091
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.364
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 176 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 294 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 305 | V → Cfs*6 | 0.002976 | INS | Frame Shift Ins | KIRC |
| 328 | C → Ffs*9 | 0.002747 | DEL | Frame Shift Del | LIHC |
| 354 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 655 | F → C | 0.001969 | SNP | Missense Mutation | LGG |
| 895 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 903 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 903 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 923 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1189 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1210 | M → Cfs*52 | 0.002506 | DEL | Frame Shift Del | COAD |
| 1289 | Y → C | 0.002294 | SNP | Missense Mutation | OV |
| 1544 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| ? | ? → ? | 0.001014 | SNP | Missense Mutation | BRCA |