Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
A2A274 ACO2 Aconitate hydratase, mitochondrial (EC 4.2.1.3) … Homo sapiens (Human) 805 aa

Protein Details: A2A274 (ACO2)

Protein Information
Accession A2A274
Protein Names Aconitate hydratase, mitochondrial (EC 4.2.1.3) (Citrate hydro-lyase)
Gene Symbol ACO2
Organism Homo sapiens (Human)
Length 805 aa
Isoforms No isoforms
Related PMIDs 31251020 31382980 32944167
Database Sources No database sources
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.900
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
36
LNCaP cells
Specificity: 0.900
36/46 (78.3%)
3
PC3 cells
Specificity: 0.075
3/4 (75.0%)
1
U937 cells
Specificity: 0.025
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MAPYSLLVTR11LQKALGVRQY21HVASVLCQRA31KVAMSHFEPN41EYIHYDLLEK
51-10051NINIVRKRLN61RPLTLSEKIV71YGHLDDPASQ81EIERGKSYLR91LRPDRVAMQD
101-150101ATAQMAMLQF111ISSGLSKVAV121PSTIHCDHLI131EAQVGGEKDL141RRAKDINQEV
151-200151YNFLATAGAK161YGVGFWKPGS171GIIHQIILEN181YAYPGVLLIG191TDSHTPNGGG
201-250201LGGICIGVGG211ADAVDVMAGI221PWELKCPKVI231GVKLTGSLSG241WSSPKDVILK
251-300251VAGILTVKGG261TGAIVEYHGP271GVDSISCTGE281EGGQATWPLP291CAGPDGSPVG
301-350301SRSGMATICN311MGAEIGATTS321VFPYNHRMKK331YLSKTGREDI341ANLADEFKDH
351-400351LVPDPGCHYD361QLIEINLSEL371KPHINGPFTP381DLAHPVAEVG391KVAEKEGWPL
401-450401DIRVGLIGSC411TNSSYEDMGR421SAAVAKQALA431HGLKCKSQFT441ITPGSEQIRA
451-500451TIERDGYAQI461LRDLGGIVLA471NACGPCIGQW481DRKDIKKGEK491NTIVTSYNRN
501-550501FTGRNDANPE511THAFVTSPEI521VTALAIAGTL531KFNPETDYLT541GTDGKKFRLE
551-600551APDADELPKG561EFDPGQDTYQ571HPPKDSSGQH581VDVSPTSQRL591QLLEPFDKWD
601-650601GKDLEDLQIL611IKVKGKCTTD621HISAAGPWLK631FRGHLDNISN641NLLIGAINIE
651-700651NGKANSVRNA661VTQEFGPVPD671TARYYKKHGI681RWVVIGDENY691GEGSSREHAA
701-750701LEPRHLGGRA711IITKSFARIH721ETNLKKQGLL731PLTFADPADY741NKIHPVDKLT
751-800751IQGLKDFTPG761KPLKCIIKHP771NGTQETILLN781HTFNETQIEW791FRAGSALNRM
801-805801KELQQ
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
27 Prediction (Medium) - -
205 Prediction (Low) - -
226 Prediction (Medium) - -
309 Prediction (Low) - -
410 Prediction (Medium) - -
435 Prediction (Medium) - -
473 Prediction (High) - -
476 Prediction (High) - -
617 Prediction (Low) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
56 R → C 0.002141 SNP Missense Mutation SKCM
141 R → C 0.001887 SNP Missense Mutation UCEC
279 G → C 0.002033 SNP Missense Mutation LUSC
564 R → C 0.003774 SNP Missense Mutation UCEC
633 R → C 0.002288 SNP Missense Mutation STAD
679 R → C 0.002427 SNP Missense Mutation BLCA
740 C → C 0.001887 SNP Silent UCEC
284* C → ? 0.002545 SNP Nonsense Mutation GBM