Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A2A3R5 | RPS6 | 40S ribosomal protein S6 | Homo sapiens (Human) | 218 aa |
Protein Details: A2A3R5 (RPS6)
Protein Information
| Accession | A2A3R5 |
|---|---|
| Protein Names | 40S ribosomal protein S6 |
| Gene Symbol | RPS6 |
| Organism | Homo sapiens (Human) |
| Length | 218 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 22496122 31251020 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MATEVAADAL11GEEWKGYVVR21ISGGNDKQGF31PMKQGVLTHG41RVRLLLSKGH
51-10051SCYRPRRTGE61RKRKSVRGCI71VDANLSVLNL81VIVKKGEKDI91PGLTDTTVPR
101-150101RLGPKRASRI111RKLFNLSKED121DVRQYVVRKP131LNKEGKKPRT141KAPKIQRLVT
151-200151PRVLQHKRRR161IALKKQRTKK171NKEEAAEYAK181LLAKRMKEAK191EKRQEQIAKR
201-218201RRLSSLRAST211SKSESSQK
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 52 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.97
|
|
| 69 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.98
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.600
3
LNCaP
Specificity: 0.600
3/3 (100.0%)
1
Jurkat T cell
Specificity: 0.200
1/1 (100.0%)
1
EC cell
Specificity: 0.200
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 22 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 31 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 131 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 183 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 191 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 191 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 232 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 236 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |