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UniProt ID Gene Symbol Protein Name Organism Length Action
A2A3R6 RPS6 40S ribosomal protein S6 Homo sapiens (Human) 249 aa

Protein Details: A2A3R6 (RPS6)

Protein Information
AccessionA2A3R6
Protein Names40S ribosomal protein S6
Gene SymbolRPS6
OrganismHomo sapiens (Human)
Length249 aa
IsoformsNo isoforms
Related PMIDs 19137006 22496122
Database SourcesNo database sources
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MKLNISFPAT11GCQKLIEVDD21ERKLRTFYEK31RMATEVAADA41LGEEWKGYVV
51-10051RISGGNDKQG61FPMKQGVLTH71GRVRLLLSKG81HSCYRPRRTG91ERKRKSVRGC
101-150101IVDANLSVLN111LVIVKKGEKD121IPGLTDTTVP131RRLGPKRASR141IRKLFNLSKE
151-200151DDVRQYVVRK161PLNKEGKKPR171TKAPKIQRLV181TPRVLQHKRR191RIALKKQRTK
201-249201KNKEEAAEYA211KLLAKRMKEA221KEKRQEQIAK231RRRLSSLRAS241TSKSESSQK
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
12 Small ribosomal subunit protein eS6 - -
GPS-Palm: 0.89
Deep-Palm: 0.16
83 - - -
GPS-Palm: 0.94
Deep-Palm: 0.97
100 - - -
GPS-Palm: 0.78
Deep-Palm: 0.98
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
1
Jurkat T cell
Specificity: 0.500
1/1 (100.0%)
1
EC cell
Specificity: 0.500
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
22 R → C 0.002141 SNP Missense Mutation SKCM
31 R → C 0.001887 SNP Missense Mutation UCEC
131 R → C 0.002427 SNP Missense Mutation BLCA
183 R → C 0.001887 SNP Missense Mutation UCEC
191 R → C 0.002506 SNP Missense Mutation COAD
191 R → C 0.003460 SNP Missense Mutation CESC
232 R → C 0.001887 SNP Missense Mutation UCEC
236 S → C 0.001014 SNP Missense Mutation BRCA