Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A2AB10 | FLOT1 | Flotillin | Homo sapiens (Human) | 252 aa |
Protein Details: A2AB10 (FLOT1)
Protein Information
| Accession | A2AB10 |
|---|---|
| Protein Names | Flotillin |
| Gene Symbol | FLOT1 |
| Organism | Homo sapiens (Human) |
| Length | 252 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19801377 29575903 31251020 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MFFTCGPNEA11MVVSGFCRSP21PVMVAGGRVF31VLPCIQQIQR41ISLNTLTLNV
51-10051KSEKVYTRHG61VPISVTGIAQ71VKIQGQNKEM81LAAACQMFLG91KTEAEIAHIA
101-150101LETLEGHQRA111IMAHMTVEEI121YKDRQKFSEQ131VFKVASSDLV141NMGISVVSYT
151-200151LKDIHDDQDY161LHSLGKARTA171QVQKDARIGE181AEAKRDAGIR191EAKAKQEKVS
201-250201AQYLSEIEMA211KAQRDYELKK221AAYDIEVNTR231RAQADLAYQL241QVAKTKQQIE
251-252251EQ
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 5 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.86
Deep-Palm: 0.02
|
|
| 17 | - |
HeLa
(29575903)
| - |
Deep-Palm: 0.84
|
|
| 34 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
|
LNCaP
(31251020)
cerebral cortex
(36430497)
|
GPS-Palm: 0.95
Deep-Palm: 0.91
|
| 85 | - | - |
LNCaP
(31251020)
cerebral cortex
(36430497)
|
GPS-Palm: 0.73
Deep-Palm: 0.94
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.267
4
LNCaP
Specificity: 0.200
4/4 (100.0%)
4
PC3
Specificity: 0.200
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.200
4/4 (100.0%)
2
HeLa cell
Specificity: 0.100
2/2 (100.0%)
1
DU145 cell
Specificity: 0.050
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.200
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.050
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 28 | R → C | 0.002545 | SNP | Missense Mutation | GBM |