Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A2BF26 | HLA-C | Major histocompatibility complex, class I, … | Homo sapiens (Human) | 397 aa |
Protein Details: A2BF26 (HLA-C)
Protein Information
| Accession | A2BF26 |
|---|---|
| Protein Names | Major histocompatibility complex, class I, C |
| Gene Symbol | HLA-C |
| Organism | Homo sapiens (Human) |
| Length | 397 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29575903 32944167 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MRVMAPRTLI11LLLSGALALT21ETWACSHSMR31YFYTAVSRPG41RGEPRFIAVG
51-10051YVDDTQFVQF61DSDAASPRGE71PRAPWVEQEG81PEYWDRETQK91YKRQAQTDRV
101-150101NLRKLRGYYN111QSEAGSHTLQ121RMYGCDLGPD131GRLLRGYNQF141AYDGKDYIAL
151-200151NEDLRSWTAA161DKAAQITQRK171WEAAREAEQR181RAYLEGTCVE191WLRRYLENGK
201-250201KTLQRAEHPK211THVTHHPVSD221HEATLRCWAL231GFYPAEITLT241WQRDGEDQTQ
251-300251DTELVETRPA261GDGTFQKWAA271VVVPSGEEQR281YTCHVQHEGL291PEPLTLRWGP
301-350301SSQPTIPIVG311IVAGLAVLAV321LAVLGAVMAV331VMCRRKSSGR341EGVRSGVWPA
351-397351TVPRALMSLS361SLVKPETAAC371VGLRCRISSH381LSFVTSRASG391ISFCKGI
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 25 | MHC class I-like antigen recognition-like superfamily MHC classes I/II-like antigen recognition protein | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.97
|
|
| 125 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.95
|
|
| 188 | - | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.98
|
|
| 227 | - | - | - |
Deep-Palm: 0.15
|
|
| 283 | SWISSPALM DBPTM CYSMODDB | - | - | - |
Deep-Palm: 0.92
|
| 333 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.98
|
|
| 370 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.95
|
|
| 375 | - | - | - |
Deep-Palm: 0.93
|
|
| 394 | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.02
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.750
3
PC3
Specificity: 0.750
3/3 (100.0%)
1
HeLa cell
Specificity: 0.250
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 233 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 283 | C → C | 0.002545 | SNP | Silent | GBM |
| 298 | W → C | 0.002141 | SNP | Missense Mutation | SKCM |