Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| A2VCT3 | OGDH | 2-oxoglutarate dehydrogenase complex component E1 … | Homo sapiens (Human) | 640 aa |
Protein Details: A2VCT3 (OGDH)
Protein Information
| Accession | A2VCT3 |
|---|---|
| Protein Names | 2-oxoglutarate dehydrogenase complex component E1 (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase) |
| Gene Symbol | OGDH |
| Organism | Homo sapiens (Human) |
| Length | 640 aa |
| Isoforms | No isoforms |
| Related PMIDs | 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501CSTPGEAQPN11VDKLVEDHLA21VQSLIRAYQI31RGHHVAQLDP41LGILDADLDS
51-10051SVPADIISST61DKLDLAVFKE71RLRMLTVGGF81YGLDESDLDK91VFHLPTTTFI
101-150101GGQESALPLR111EIIRRLEMAY121CQHIGVEFMF131INDLEQCQWI141RQKFETPGIM
151-200151QFTNEEKRTL161LARLVRSTRF171EEFLQRKWSS181EKRFGLEGCE191VLIPALKTII
201-250201DKSSENGVDY211VIMGMPHRGR221LNVLANVIRK231ELEQIFCQFD241SKLEAADEGS
251-300251GDVKYHLGMY261HRRINRVTDR271NITLSLVANP281SHLEAADPVV291MGKTKAEQFY
301-350301CGDTEGKKVM311SILLHGDAAF321AGQGIVYETF331HLSDLPSYTT341HGTVHVVVNN
351-400351QIGFTTDPRM361ARSSPYPTDV371ARVVNAPIFH381VNSDDPEAVM391YVCKVAAEWR
401-450401STFHKDVVVD411LVCYRRNGHN421EMDEPMFTQP431LMYKQIRKQK441PVLQKYAELL
451-500451VSQGVVNQPE461YEEEISKYDK471ICEEAFARSK481DEKILHIKHW491LDSPWPGFFT
501-550501LDGQPRSMSC511PSTGLTEDIL521THIGNVASSV531PVENFTIHGG541LSRILKTRGE
551-600551MVKNRTVDWA561LAEYMAFGSL571LKEGIHIRLS581GQDVERGTFS591HRHHVLHDQN
601-640601VDKRTCIPMN611HLWPNQAPYT621VCNSSLSEYG631VLGFELCFTR
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 1 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.02
|
|
| 121 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.70
|
|
| 137 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.05
|
|
| 189 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
|
GPS-Palm: 0.91
Deep-Palm: 0.97
|
|
| 237 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.81
Deep-Palm: 0.94
|
|
| 301 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.69
Deep-Palm: 0.91
|
|
| 393 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.11
|
|
| 413 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
|
GPS-Palm: 0.87
Deep-Palm: 0.38
|
|
| 472 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.84
Deep-Palm: 0.61
|
|
| 510 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.78
Deep-Palm: 0.77
|
|
| 606 | - | - | - |
Deep-Palm: 0.04
|
|
| 622 | - | - | - |
Deep-Palm: 0.27
|
|
| 637 | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.03
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
cerebral cortex
Specificity: 0.500
4/4 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.500
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 41 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 81 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 81 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 277 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 283 | C → C | 0.001887 | SNP | Silent | UCEC |
| 604 | C → C | 0.001764 | SNP | Silent | LUAD |
| 653 | W → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 686 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 700 | C → S | 0.001764 | SNP | Missense Mutation | LUAD |
| 713 | Y → C | 0.002976 | SNP | Missense Mutation | KIRC |
| 769 | W → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 794 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 864 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 904 | C → C | 0.001969 | SNP | Silent | LGG |
| 909 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |