Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
A6H8L4 ADAM17 ADAM metallopeptidase domain 17 (ADAM17 … Homo sapiens (Human) 258 aa

Protein Details: A6H8L4 (ADAM17)

Protein Information
Accession A6H8L4
Protein Names ADAM metallopeptidase domain 17 (ADAM17 protein)
Gene Symbol ADAM17
Organism Homo sapiens (Human)
Length 258 aa
Isoforms No isoforms
Related PMIDs 19801377 32944167
Database Sources No database sources
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
4
PC3 cells
Specificity: 0.667
4/4 (100.0%)
2
DU145 cells
Specificity: 0.333
2/2 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MRQSLLFLTS11VVPFVLAPRP21PDDPGFGPHQ31RLEKLDSLLS41DYDILSLSNI
51-10051QQHSVRKRDL61QTSTHVETLL71TFSALKRHFK81LYLTSSTERF91SQNFKVVVVD
101-150101GKNESEYTVK111WQDFFTGHVV121GEPDSRVLAH131IRDDDVIIRI141NTDGAEYNIE
151-200151PLWRFVNDTK161DKRMLVYKSE171DIKNVSRLQS181PKVCGYLKVD191NEELLPKGLV
201-250201DREPPEELVH211RVKRRADPDP221MKNTCKLLVV231ADHRFYRYMG241RGEESTTTNY
251-258251LIHTDRAN
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
184 Prediction (Low) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
177 R → C 0.002506 SNP Missense Mutation COAD
283 R → C 0.002545 SNP Missense Mutation GBM
330 S → C 0.002506 SNP Missense Mutation COAD
519 S → C 0.001969 SNP Missense Mutation HNSC
630 C → C 0.001887 SNP Silent UCEC
641 C → C 0.001014 SNP Silent BRCA
641 C → Y 0.001887 SNP Missense Mutation UCEC
785 S → C 0.002545 SNP Missense Mutation GBM
786 S → C 0.002294 SNP Missense Mutation OV
813 R → C 0.001014 SNP Missense Mutation BRCA
813 R → C 0.001969 SNP Missense Mutation HNSC
824 C → C 0.001887 SNP Silent UCEC