Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| B0QY89 | EIF3L | Eukaryotic translation initiation factor 3 … | Homo sapiens (Human) | 607 aa |
Protein Details: B0QY89 (EIF3L)
Protein Information
| Accession | B0QY89 |
|---|---|
| Protein Names | Eukaryotic translation initiation factor 3 subunit L (eIF3l) (Eukaryotic translation initiation factor 3 subunit 6-interacting protein) (Eukaryotic translation initiation factor 3 subunit E-interacting protein) |
| Gene Symbol | EIF3L |
| Organism | Homo sapiens (Human) |
| Length | 607 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31382980 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MARGLGKASG11FPAGPSGAEL21PASGRRRGPL31ISLFPAVLAS41EAAMSYPADD
51-10051YESEAAYDPY61AYPSDYDMHT71GDPKQDLAYE81RQYEQQTYQV91IPEVIKNFIQ
101-150101YFHKTVSDLI111DQKVYELQAS121RVSSDVIDQK131VYEIQDIYEN141SWTKLTERFF
151-200151KNTPWPEAEA161IAPQVGNDAV171FLILYKELYY181RHIYAKVSGG191PSLEQRFESY
201-250201YNYCNLFNYI211LNADGPAPLE221LPNQWLWDII231DEFIYQFQSF241SQYRCKTAKK
251-300251SEEEIDFLRS261NPKIWNVHSV271LNVLHSLVDK281SNINRQLEVY291TSGGDPESVA
301-350301GEYGRHSLYK311MLGYFSLVGL321LRLHSLLGDY331YQAIKVLENI341ELNKKSMYSR
351-400351VPECQVTTYY361YVGFAYLMMR371RYQDAIRVFA381NILLYIQRTK391SMFQRTTYKY
401-450401EMINKQNEQM411HALLAIALTM421YPMRIDESIH431LQLREKYGDK441MLRMQKGDPQ
451-500451VYEELFSYSC461PKFLSPVVPN471YDNVHPNYHK481EPFLQQLKVF491SDEVQQQAQL
501-550501STIRSFLKLY511TTMPVAKLAG521FLDLTEQEFR531IQLLVFKHKM541KNLVWTSGIS
551-600551ALDGEFQSAS561EVDFYIDKDM571IHIADTKVAR581RYGDFFIRQI591HKFEELNRTL
601-607601KKMGQRP
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 204 | - | - | - |
Deep-Palm: 0.30
|
|
| 245 | - | - | - |
Deep-Palm: 0.49
|
|
| 354 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.11
|
|
| 460 | SWISSPALM DBPTM CYSMODDB | RNA polymerase I-associated factor PAF67 |
HeLa
(29575903)
| - |
Deep-Palm: 0.27
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
U937 cell
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 216 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 216 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 217 | S → C | 0.002294 | SNP | Missense Mutation | OV |
| 279 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 400 | R → C | 0.010870 | SNP | Missense Mutation | ACC |
| 467 | Y → C | 0.003460 | SNP | Missense Mutation | CESC |