Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| B3KQV6 | PPP2R1A | Protein phosphatase 2 scaffold subunit … | Homo sapiens (Human) | 410 aa |
Protein Details: B3KQV6 (PPP2R1A)
Protein Information
| Accession | B3KQV6 |
|---|---|
| Protein Names | Protein phosphatase 2 scaffold subunit Aalpha (cDNA FLJ33169 fis, clone ADRGL2000384, highly similar to Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform) |
| Gene Symbol | PPP2R1A |
| Organism | Homo sapiens (Human) |
| Length | 410 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 31382980 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MVRRAAASKL11GEFAKVLELD21NVKSEIIPMF31SNLASDEQDS41VRLLAVEACV
51-10051NIAQLLPQED61LEALVMPTLR71QAAEDKSWRV81RYMVADKFTE91LQKAVGPEIT
101-150101KTDLVPAFQN111LMKDCEAEVR121AAASHKVKEF131CENLSADCRE141NVIMSQILPC
151-200151IKELVSDANQ161HVKSALASVI171MGLSPILGKD181NTIEHLLPLF191LAQLKDECPE
201-250201VRLNIISNLD211CVNEVIGIRQ221LSQSLLPAIV231ELAEDAKWRV241RLAIIEYMPL
251-300251LAGQLGVEFF261DEKLNSLCMA271WLVDHVYAIR281EAATSNLKKL291VEKFGKEWAH
301-350301ATIIPKVLAM311SGDPNYLHRM321TTLFCINVLS331EVCGQDITTK341HMLPTVLRMA
351-400351GDPVANVRFN361VAKSLQKIGP371ILDNSTLQSE381VKPILEKLTQ391DQDVDVKYFA
401-410401QEALTVLSLA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 49 | Armadillo-like helical Protein Phosphatase 2A Regulatory Subunit A | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.96
|
|
| 115 | - | - | - |
Deep-Palm: 0.94
|
|
| 131 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.90
|
|
| 138 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.45
|
|
| 150 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.84
Deep-Palm: 0.77
|
|
| 198 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.81
Deep-Palm: 0.95
|
|
| 211 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
|
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.90
Deep-Palm: 0.87
|
| 268 | - | - | - |
Deep-Palm: 0.77
|
|
| 325 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.27
|
|
| 333 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.37
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.364
4
PC3
Specificity: 0.286
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.286
4/4 (100.0%)
2
LNCaP
Specificity: 0.143
2/2 (100.0%)
1
U937 cell
Specificity: 0.071
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
Cerebral Cortex (Mass)
Specificity: 0.214
3/4 (75.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 28 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 111 | S → C | 0.002545 | SNP | Missense Mutation | GBM |
| 144 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 148 | C → C | 0.001887 | SNP | Silent | UCEC |
| 148 | C → Y | 0.005435 | SNP | Missense Mutation | ESCA |
| 257 | W → C | 0.002294 | SNP | Missense Mutation | OV |
| 258 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 329 | C → F | 0.001764 | SNP | Missense Mutation | LUAD |
| 377 | C → F | 0.001764 | SNP | Missense Mutation | LUAD |
| 456 | Y → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 459 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 459 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 480 | A → Cfs*31 | 0.001969 | INS | Frame Shift Ins | HNSC |