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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
B3KQV6 PPP2R1A Protein phosphatase 2 scaffold subunit … Homo sapiens (Human) 410 aa

Protein Details: B3KQV6 (PPP2R1A)

Protein Information
Accession B3KQV6
Protein Names Protein phosphatase 2 scaffold subunit Aalpha (cDNA FLJ33169 fis, clone ADRGL2000384, highly similar to Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform)
Gene Symbol PPP2R1A
Organism Homo sapiens (Human)
Length 410 aa
Isoforms No isoforms
Related PMIDs 21076176 22496122 29575903 31251020 31382980 32944167
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.750
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
24
LNCaP cells
Specificity: 0.750
24/46 (52.2%)
4
PC3 cells
Specificity: 0.125
4/4 (100.0%)
2
Jurkat T cells
Specificity: 0.062
2/25 (8.0%)
1
U937 cells
Specificity: 0.031
1/1 (100.0%)
1
Endothelial cells
Specificity: 0.031
1/2 (50.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MVRRAAASKL11GEFAKVLELD21NVKSEIIPMF31SNLASDEQDS41VRLLAVEACV
51-10051NIAQLLPQED61LEALVMPTLR71QAAEDKSWRV81RYMVADKFTE91LQKAVGPEIT
101-150101KTDLVPAFQN111LMKDCEAEVR121AAASHKVKEF131CENLSADCRE141NVIMSQILPC
151-200151IKELVSDANQ161HVKSALASVI171MGLSPILGKD181NTIEHLLPLF191LAQLKDECPE
201-250201VRLNIISNLD211CVNEVIGIRQ221LSQSLLPAIV231ELAEDAKWRV241RLAIIEYMPL
251-300251LAGQLGVEFF261DEKLNSLCMA271WLVDHVYAIR281EAATSNLKKL291VEKFGKEWAH
301-350301ATIIPKVLAM311SGDPNYLHRM321TTLFCINVLS331EVCGQDITTK341HMLPTVLRMA
351-400351GDPVANVRFN361VAKSLQKIGP371ILDNSTLQSE381VKPILEKLTQ391DQDVDVKYFA
401-410401QEALTVLSLA
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
49 Prediction (Low) - -
150 Prediction (Medium) - -
198 Prediction (Medium) - -
211 Experimental CYSMODDB SWISSPALM DBPTM Prediction (High) - 29575903
325 Prediction (Low) - -
333 Prediction (Low) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
28 R → C 0.001887 SNP Missense Mutation UCEC
111 S → C 0.002545 SNP Missense Mutation GBM
144 R → C 0.001887 SNP Missense Mutation UCEC
148 C → C 0.001887 SNP Silent UCEC
148 C → Y 0.005435 SNP Missense Mutation ESCA
257 W → C 0.002294 SNP Missense Mutation OV
258 R → C 0.001887 SNP Missense Mutation UCEC
329 C → F 0.001764 SNP Missense Mutation LUAD
377 C → F 0.001764 SNP Missense Mutation LUAD
456 Y → C 0.001969 SNP Missense Mutation HNSC
459 R → C 0.002141 SNP Missense Mutation SKCM
459 R → C 0.001887 SNP Missense Mutation UCEC
480 A → Cfs*31 0.001969 INS Frame Shift Ins HNSC