Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| B4DKB2 | ECE1 | Endothelin-converting enzyme 1 (EC 3.4.24.71) | Homo sapiens (Human) | 738 aa |
Protein Details: B4DKB2 (ECE1)
Protein Information
| Accession | B4DKB2 |
|---|---|
| Protein Names | Endothelin-converting enzyme 1 (EC 3.4.24.71) |
| Gene Symbol | ECE1 |
| Organism | Homo sapiens (Human) |
| Length | 738 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19801377 22496122 29575903 31251020 32651440 32944167 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.804
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
37
LNCaP cells
Specificity: 0.804
37/46 (80.4%)
4
PC3 cells
Specificity: 0.087
4/4 (100.0%)
2
DU145 cells
Specificity: 0.043
2/2 (100.0%)
1
Jurkat T cells
Specificity: 0.022
1/25 (4.0%)
1
HeLa cells
Specificity: 0.022
1/1 (100.0%)
1
Endothelial cells
Specificity: 0.022
1/2 (50.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MRGVWPPPVS11ALLSALGMST21YKRATLDEED31LVDSLSEGDA41YPNGLQVNFH
51-10051SPRSGQRCWA61ARTQVEKRLV71VLVVLLAAGL81VACLAALGIQ91YQTRSPSVCL
101-150101SEACVSVTSS111ILSSMDPTVD121PCHDFFSYAC131GGWIKANPVP141DGHSRWGTFS
151-200151NLWEHNQAII161KHLLENSTAS171VSEAERKAQV181YYRACMNETR191IEELRAKPLM
201-250201ELIERLGGWN211ITGPWAKDNF221QDTLQVVTAH231YRTSPFFSVY241VSADSKNSNS
251-300251NVIQVDQSGL261GLPSRDYYLN271KTENEKVLTG281YLNYMVQLGK291LLGGGDEEAI
301-350301RPQMQQILDF311ETALANITIP321QEKRRDEELI331YHKVTAAELQ341TLAPAINWLP
351-400351FLNTIFYPVE361INESEPIVVY371DKEYLEQIST381LINTTDRCLL391NNYMIWNLVR
401-450401KTSSFLDQRF411QDADEKFMEV421MYGTKKTCLP431RWKFCVSDTE441NNLGFALGPM
451-500451FVKATFAEDS461KSIATEIILE471IKKAFEESLS481TLKWMDEETR491KSAKEKADAI
501-550501YNMIGYPNFI511MDPKELDKVF521NDYTAVPDLY531FENAMRFFNF541SWRVTADQLR
551-600551KAPNRDQWSM561TPPMVNAYYS571PTKNEIVFPA581GILQAPFYTR591SSPKALNFGG
601-650601IGVVVGHELT611HAFDDQGREY621DKDGNLRPWW631KNSSVEAFKR641QTECMVEQYS
651-700651NYSVNGEPVN661GRHTLGENIA671DNGGLKAAYR681VWCSVRTPES691SHEGLITDPH
701-738701SPSRFRVIGS711LSNSKEFSEH721FRCPPGSPMN731PPHKCEVW
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 58 | CYSMODDB SWISSPALM DBPTM Prediction (Low) | - | - |
| 83 | Prediction (Medium) | - | - |
| 185 | Prediction (Low) | - | - |
| 428 | Prediction (Medium) | - | - |
| 435 | Prediction (High) | - | - |
| 683 | Prediction (Low) | - | - |
| 735 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 83 | C → Y | 0.002288 | SNP | Missense Mutation | STAD |
| 83 | C → F | 0.002141 | SNP | Missense Mutation | SKCM |
| 104 | C → C | 0.002288 | SNP | Silent | STAD |
| 183 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 208 | G → C | 0.002506 | SNP | Missense Mutation | COAD |
| 232 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 409 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 509 | F → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 630 | W → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 736 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 767 | C → C | 0.002506 | SNP | Silent | COAD |