Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| B4DKB2 | ECE1 | Endothelin-converting enzyme 1 (EC 3.4.24.71) | Homo sapiens (Human) | 738 aa |
Protein Details: B4DKB2 (ECE1)
Protein Information
| Accession | B4DKB2 |
|---|---|
| Protein Names | Endothelin-converting enzyme 1 (EC 3.4.24.71) |
| Gene Symbol | ECE1 |
| Organism | Homo sapiens (Human) |
| Length | 738 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19801377 22496122 29575903 31251020 32651440 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MRGVWPPPVS11ALLSALGMST21YKRATLDEED31LVDSLSEGDA41YPNGLQVNFH
51-10051SPRSGQRCWA61ARTQVEKRLV71VLVVLLAAGL81VACLAALGIQ91YQTRSPSVCL
101-150101SEACVSVTSS111ILSSMDPTVD121PCHDFFSYAC131GGWIKANPVP141DGHSRWGTFS
151-200151NLWEHNQAII161KHLLENSTAS171VSEAERKAQV181YYRACMNETR191IEELRAKPLM
201-250201ELIERLGGWN211ITGPWAKDNF221QDTLQVVTAH231YRTSPFFSVY241VSADSKNSNS
251-300251NVIQVDQSGL261GLPSRDYYLN271KTENEKVLTG281YLNYMVQLGK291LLGGGDEEAI
301-350301RPQMQQILDF311ETALANITIP321QEKRRDEELI331YHKVTAAELQ341TLAPAINWLP
351-400351FLNTIFYPVE361INESEPIVVY371DKEYLEQIST381LINTTDRCLL391NNYMIWNLVR
401-450401KTSSFLDQRF411QDADEKFMEV421MYGTKKTCLP431RWKFCVSDTE441NNLGFALGPM
451-500451FVKATFAEDS461KSIATEIILE471IKKAFEESLS481TLKWMDEETR491KSAKEKADAI
501-550501YNMIGYPNFI511MDPKELDKVF521NDYTAVPDLY531FENAMRFFNF541SWRVTADQLR
551-600551KAPNRDQWSM561TPPMVNAYYS571PTKNEIVFPA581GILQAPFYTR591SSPKALNFGG
601-650601IGVVVGHELT611HAFDDQGREY621DKDGNLRPWW631KNSSVEAFKR641QTECMVEQYS
651-700651NYSVNGEPVN661GRHTLGENIA671DNGGLKAAYR681VWCSVRTPES691SHEGLITDPH
701-738701SPSRFRVIGS711LSNSKEFSEH721FRCPPGSPMN731PPHKCEVW
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 58 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
| - |
GPS-Palm: 0.72
Deep-Palm: 0.95
|
| 83 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.98
|
|
| 99 | - | - | - |
Deep-Palm: 0.90
|
|
| 104 | - | - | - |
Deep-Palm: 0.74
|
|
| 122 | - | - | - |
Deep-Palm: 0.09
|
|
| 130 | - | - | - |
Deep-Palm: 0.11
|
|
| 185 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.96
|
|
| 388 | - | - | - |
Deep-Palm: 0.24
|
|
| 428 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.37
|
|
| 435 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.92
Deep-Palm: 0.68
|
|
| 644 | - | - | - |
Deep-Palm: 0.13
|
|
| 683 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.95
|
|
| 723 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.63
|
|
| 735 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.01
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
4
LNCaP
Specificity: 0.400
4/4 (100.0%)
1
HeLa cell
Specificity: 0.100
1/1 (100.0%)
1
Jurkat T cell
Specificity: 0.100
1/1 (100.0%)
1
EC cell
Specificity: 0.100
1/1 (100.0%)
1
DU145 cell
Specificity: 0.100
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
LNCaP cells (Mass)
Specificity: 0.200
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 83 | C → Y | 0.002288 | SNP | Missense Mutation | STAD |
| 83 | C → F | 0.002141 | SNP | Missense Mutation | SKCM |
| 104 | C → C | 0.002288 | SNP | Silent | STAD |
| 183 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 208 | G → C | 0.002506 | SNP | Missense Mutation | COAD |
| 232 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 409 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 509 | F → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 630 | W → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 736 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 767 | C → C | 0.002506 | SNP | Silent | COAD |