Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
B4DNK4 PKM Pyruvate kinase (EC 2.7.1.40) Homo sapiens (Human) 457 aa

Protein Details: B4DNK4 (PKM)

Protein Information
Accession B4DNK4
Protein Names Pyruvate kinase (EC 2.7.1.40)
Gene Symbol PKM
Organism Homo sapiens (Human)
Length 457 aa
Isoforms No isoforms
Related PMIDs 29575903 31251020 32944167 36430497
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
36
LNCaP cells
Specificity: 0.800
36/46 (78.3%)
4
PC3 cells
Specificity: 0.089
4/4 (100.0%)
4
Cerebral cortex
Specificity: 0.089
4/4 (100.0%)
1
HeLa cells
Specificity: 0.022
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MSKPHSEAGT11AFIQTQQLHA21AMADTFLEHM31CRLDIDSPPI41TARNTGIICT
51-10051IGPASRSVEL61KKGATLKITL71DNAYMEKCDE81NILWLDYKNI91CKVVEVGSKI
101-150101YVDDGLISLQ111VKQKGADFLV121TEVENGGSLG131SKKGVNLPGA141AVDLPAVSEK
151-200151DIQDLKFGVE161QDVDMVFASF171IRKASDVHEV181RKVLGEKGKN191IKIISKIENH
201-250201EGVRRFDEIL211EASDGIMVAR221GDLGIEIPAE231KVFLAQKMMI241GRCNRAGKPV
251-300251ICATQMLESM261IKKPRPTRAE271GSDVANAVLD281GADCIMLSGE291TAKGDYPLEA
301-350301VRMQHLIARE311AEAAIYHLQL321FEELRRLAPI331TSDPTEATAV341GAVEASFKCC
351-400351SGAIIVLTKS361GRSAHQVARY371RPRAPIIAVT381RNPQTARQAH391LYRGIFPVLC
401-450401KDPVQEAWAE411DVDLRVNFAM421NVGKARGFFK431KGDVVIVLTG441WRPGSGFTNT
451-457451MRVVPVP
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
49 Experimental Prediction (Medium) - 29575903
91 Prediction (Low) - -
243 Prediction (High) - -
252 Prediction (Medium) - -
284 Experimental Prediction (Medium) Pyruvate kinase barrel domain 29575903
349 Experimental Prediction (High) Pyruvate kinase alpha/beta domain 29575903
350 Experimental Prediction (High) Pyruvate kinase alpha/beta domain 29575903
400 Experimental CYSMODDB SWISSPALM DBPTM Pyruvate kinase alpha/beta domain 29575903
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
32 R → C 0.002288 SNP Missense Mutation STAD
49 C → Y 0.002288 SNP Missense Mutation STAD
92 R → C 0.001887 SNP Missense Mutation UCEC
158 W → C 0.010870 SNP Missense Mutation ACC
298 G → C 0.001887 SNP Missense Mutation UCEC
307 F → C 0.007299 SNP Missense Mutation READ
317 C → Y 0.001014 SNP Missense Mutation BRCA
376 R → C 0.002545 SNP Missense Mutation GBM
467 R → C 0.002288 SNP Missense Mutation STAD
467 R → C 0.002033 SNP Missense Mutation LUSC
516 R → C 0.001887 SNP Missense Mutation UCEC