Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| B4DNK4 | PKM | Pyruvate kinase (EC 2.7.1.40) | Homo sapiens (Human) | 457 aa |
Protein Details: B4DNK4 (PKM)
Protein Information
| Accession | B4DNK4 |
|---|---|
| Protein Names | Pyruvate kinase (EC 2.7.1.40) |
| Gene Symbol | PKM |
| Organism | Homo sapiens (Human) |
| Length | 457 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSKPHSEAGT11AFIQTQQLHA21AMADTFLEHM31CRLDIDSPPI41TARNTGIICT
51-10051IGPASRSVEL61KKGATLKITL71DNAYMEKCDE81NILWLDYKNI91CKVVEVGSKI
101-150101YVDDGLISLQ111VKQKGADFLV121TEVENGGSLG131SKKGVNLPGA141AVDLPAVSEK
151-200151DIQDLKFGVE161QDVDMVFASF171IRKASDVHEV181RKVLGEKGKN191IKIISKIENH
201-250201EGVRRFDEIL211EASDGIMVAR221GDLGIEIPAE231KVFLAQKMMI241GRCNRAGKPV
251-300251ICATQMLESM261IKKPRPTRAE271GSDVANAVLD281GADCIMLSGE291TAKGDYPLEA
301-350301VRMQHLIARE311AEAAIYHLQL321FEELRRLAPI331TSDPTEATAV341GAVEASFKCC
351-400351SGAIIVLTKS361GRSAHQVARY371RPRAPIIAVT381RNPQTARQAH391LYRGIFPVLC
401-450401KDPVQEAWAE411DVDLRVNFAM421NVGKARGFFK431KGDVVIVLTG441WRPGSGFTNT
451-457451MRVVPVP
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 31 | Pyruvate kinase, C-terminal domain superfamily | - |
Unknown
(32651440)
cerebral cortex
(36430497)
|
Deep-Palm: 0.40
|
|
| 49 | - |
HeLa
(29575903)
|
LNCaP
(31251020)
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.89
Deep-Palm: 0.91
|
|
| 78 | - | - |
LNCaP
(31251020)
Unknown
(32651440)
cerebral cortex
(36430497)
|
Deep-Palm: 0.34
|
|
| 91 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.67
|
|
| 243 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.89
|
|
| 252 | - | - |
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.86
Deep-Palm: 0.77
|
|
| 284 | Pyruvate kinase, barrel domain |
HeLa
(29575903)
|
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.81
Deep-Palm: 0.85
|
|
| 349 | Pyruvate kinase, alpha/beta domain |
HeLa
(29575903)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.92
Deep-Palm: 0.96
|
|
| 350 | Pyruvate kinase, alpha/beta domain |
HeLa
(29575903)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.95
Deep-Palm: 0.95
|
|
| 400 | SWISSPALM DBPTM CYSMODDB | Pyruvate kinase alpha/beta domain |
HeLa
(29575903)
|
Unknown
(32651440)
cerebral cortex
(36430497)
|
Deep-Palm: 0.94
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.364
4
PC3
Specificity: 0.250
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.250
4/4 (100.0%)
3
LNCaP
Specificity: 0.188
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.250
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.062
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 32 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 49 | C → Y | 0.002288 | SNP | Missense Mutation | STAD |
| 92 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 158 | W → C | 0.010870 | SNP | Missense Mutation | ACC |
| 298 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 307 | F → C | 0.007299 | SNP | Missense Mutation | READ |
| 317 | C → Y | 0.001014 | SNP | Missense Mutation | BRCA |
| 376 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 467 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 467 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 516 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |