Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| B4DR61 | SEC61A1 | SEC61 translocon subunit alpha 1 … | Homo sapiens (Human) | 482 aa |
Protein Details: B4DR61 (SEC61A1)
Protein Information
| Accession | B4DR61 |
|---|---|
| Protein Names | SEC61 translocon subunit alpha 1 (cDNA FLJ59739, highly similar to Protein transport protein Sec61 subunit alpha isoform 1) |
| Gene Symbol | SEC61A1 |
| Organism | Homo sapiens (Human) |
| Length | 482 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 31382980 32944167 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.789
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
15
LNCaP cells
Specificity: 0.789
15/46 (32.6%)
3
PC3 cells
Specificity: 0.158
3/4 (75.0%)
1
U937 cells
Specificity: 0.053
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MTQTARVLVK11FLEVIKPFCV21ILPEIQKPER31KIQFKEKVLW41TAITLFIFLV
51-10051CCQIPLFGIM61SSDSADPFYW71MRVILASNRG81TLMELGISPI91VTSGLIMQLL
101-150101AGAKIIEVGD111TPKDRALFNG121AQKLFGMIIT131IGQSIVYVMT141GMYGDPSEMG
151-200151AGICLLITIQ161LFVAGLIVLL171LDELLQKGYG181LGSGISLFIA191TNICETIVWK
201-250201AFSPTTVNTG211RGMEFEGAII221ALFHLLATRT231DKVRALREAF241YRQNLPNLMN
251-300251LIATIFVFAV261VIYFQGFRVD271LPIKSARYRG281QYNTYPIKLF291YTSNIPIILQ
301-350301SALVSNLYVI311SQMLSARFSG321NLLVSLLGTW331SDTSSGGPAR341AYPVGGLCYY
351-400351LSPPESFGSV361LEDPVHAVVY371IVFMLGSCAF381FSKTWIEVSG391SSAKDVAKQL
401-450401KEQQMVMRGH411RETSMVHELN421RYIPTAAAFG431GLCIGALSVL441ADFLGAIGSG
451-482451TGILLAVTII461YQYFEIFVKE471QSEVGSMGAL481LF
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 19 | CYSMODDB SWISSPALM DBPTM Prediction (Medium) | - | - |
| 51 | Prediction (Medium) | - | - |
| 52 | Prediction (Medium) | - | - |
| 194 | Prediction (Medium) | - | - |
| 378 | Prediction (Low) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 45 | C → R | 0.002288 | SNP | Missense Mutation | STAD |
| 188 | C → F | 0.001014 | SNP | Missense Mutation | BRCA |
| 236 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 285 | Y → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 311 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 386 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |