Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| B4DR61 | SEC61A1 | SEC61 translocon subunit alpha 1 … | Homo sapiens (Human) | 482 aa |
Protein Details: B4DR61 (SEC61A1)
Protein Information
| Accession | B4DR61 |
|---|---|
| Protein Names | SEC61 translocon subunit alpha 1 (cDNA FLJ59739, highly similar to Protein transport protein Sec61 subunit alpha isoform 1) |
| Gene Symbol | SEC61A1 |
| Organism | Homo sapiens (Human) |
| Length | 482 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 31382980 32944167 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MTQTARVLVK11FLEVIKPFCV21ILPEIQKPER31KIQFKEKVLW41TAITLFIFLV
51-10051CCQIPLFGIM61SSDSADPFYW71MRVILASNRG81TLMELGISPI91VTSGLIMQLL
101-150101AGAKIIEVGD111TPKDRALFNG121AQKLFGMIIT131IGQSIVYVMT141GMYGDPSEMG
151-200151AGICLLITIQ161LFVAGLIVLL171LDELLQKGYG181LGSGISLFIA191TNICETIVWK
201-250201AFSPTTVNTG211RGMEFEGAII221ALFHLLATRT231DKVRALREAF241YRQNLPNLMN
251-300251LIATIFVFAV261VIYFQGFRVD271LPIKSARYRG281QYNTYPIKLF291YTSNIPIILQ
301-350301SALVSNLYVI311SQMLSARFSG321NLLVSLLGTW331SDTSSGGPAR341AYPVGGLCYY
351-400351LSPPESFGSV361LEDPVHAVVY371IVFMLGSCAF381FSKTWIEVSG391SSAKDVAKQL
401-450401KEQQMVMRGH411RETSMVHELN421RYIPTAAAFG431GLCIGALSVL441ADFLGAIGSG
451-482451TGILLAVTII461YQYFEIFVKE471QSEVGSMGAL481LF
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 19 | SWISSPALM DBPTM CYSMODDB | SecY domain superfamily | - |
LNCaP
(31251020)
|
GPS-Palm: 0.88
Deep-Palm: 0.96
|
| 51 | Translocon Sec61/SecY, plug domain SecY domain superfamily SecY/SEC61-alpha family | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.36
|
|
| 52 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.40
|
|
| 154 | - | - | - |
Deep-Palm: 0.94
|
|
| 194 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.60
|
|
| 348 | - | - | - |
Deep-Palm: 0.97
|
|
| 378 | - | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.32
|
|
| 433 | - | - | - |
Deep-Palm: 0.90
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.600
3
PC3
Specificity: 0.600
3/3 (100.0%)
1
LNCaP
Specificity: 0.200
1/1 (100.0%)
1
U937 cell
Specificity: 0.200
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 45 | C → R | 0.002288 | SNP | Missense Mutation | STAD |
| 188 | C → F | 0.001014 | SNP | Missense Mutation | BRCA |
| 236 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 285 | Y → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 311 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 386 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |