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Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| B4DV51 | RAN | GTP-binding nuclear protein Ran | Homo sapiens (Human) | 128 aa |
Protein Details: B4DV51 (RAN)
Protein Information
| Accession | B4DV51 |
|---|---|
| Protein Names | GTP-binding nuclear protein Ran |
| Gene Symbol | RAN |
| Organism | Homo sapiens (Human) |
| Length | 128 aa |
| Isoforms | No isoforms |
| Related PMIDs | 22496122 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MFDVTSRVTY11KNVPNWHRDL21VRVCENIPIV31LCGNKVDIKD41RKVKAKSIVF
51-10051HRKKNLQYYD61ISAKSNYNFE71KPFLWLARKL81IGDPNLEFVA91MPALAPPEVV
101-128101MDPALAAQYE111HDLEVAQTTA121LPDEDDDL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 24 | SWISSPALM DBPTM CYSMODDB | Ras family P-loop containing nucleoside triphosphate hydrolase Small GTPase Ran GTPase |
HeLa
(29575903)
|
cerebral cortex
(36430497)
Unknown
(32651440)
|
Deep-Palm: 0.91
|
| 32 | SWISSPALM DBPTM CYSMODDB | Ras family P-loop containing nucleoside triphosphate hydrolase Small GTPase Ran GTPase |
HeLa
(29575903)
|
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.87
Deep-Palm: 0.97
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
4
cerebral cortex
Specificity: 0.444
4/4 (100.0%)
3
LNCaP
Specificity: 0.333
3/3 (100.0%)
1
EC cell
Specificity: 0.111
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
Jurkat T cells (Mass)
Specificity: 0.111
1/10 (10.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 85 | C → C | 0.002033 | SNP | Silent | LUSC |