Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| B4DXW1 | ACTR3 | Actin related protein 3 (cDNA … | Homo sapiens (Human) | 367 aa |
Protein Details: B4DXW1 (ACTR3)
Protein Information
| Accession | B4DXW1 |
|---|---|
| Protein Names | Actin related protein 3 (cDNA FLJ51148, highly similar to Actin-like protein 3) (cDNA FLJ52434, highly similar to Actin-like protein 3) (cDNA, FLJ79112, highly similar to Actin-like protein 3) (cDNA, FLJ79295, highly similar to Actin-like protein 3) |
| Gene Symbol | ACTR3 |
| Organism | Homo sapiens (Human) |
| Length | 367 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MKGVDDLDFF11IGDEAIEKPT21YATKWPIRHG31IVEDWDLMER41FMEQVIFKYL
51-10051RAEPEDHYFL61LTEPPLNTPE71NREYTAEIMF81ESFNVPGLYI91AVQAVLALAA
101-150101SWTSRQVGER111TLTGTVIDSG121DGVTHVIPVA131EGYVIGSCIK141HIPIAGRDIT
151-200151YFIQQLLRDR161EVGIPPEQSL171ETAKAVKERY181SYVCPDLVKE191FNKYDTDGSK
201-250201WIKQYTGINA211ISKKEFSIDV221GYERFLGPEI231FFHPEFANPD241FTQPISEVVD
251-300251EVIQNCPIDV261RRPLYKNIVL271SGGSTMFRDF281GRRLQRDLKR291TVDARLKLSE
301-350301ELSGGRLKPK311PIDVQVITHH321MQRYAVWFGG331SMLASTPEFY341QVCHTKKDYE
351-367351EIGPSICRHN361PVFGVMS
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 138 | SWISSPALM DBPTM CYSMODDB | Actin |
HeLa
(29575903)
| - |
GPS-Palm: 0.82
Deep-Palm: 0.78
|
| 184 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.89
|
|
| 256 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.77
|
|
| 343 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.25
|
|
| 357 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.02
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
PC3
Specificity: 0.400
4/4 (100.0%)
2
cerebral cortex
Specificity: 0.200
2/2 (100.0%)
1
LNCaP
Specificity: 0.100
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
Cerebral Cortex (Mass)
Specificity: 0.300
3/4 (75.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 34 | C → C | 0.001887 | SNP | Splice Region | UCEC |
| 230 | R → C | 0.007299 | SNP | Missense Mutation | READ |