Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| B7Z4L4 | RPN1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 | Homo sapiens (Human) | 435 aa |
Protein Details: B7Z4L4 (RPN1)
Protein Information
| Accession | B7Z4L4 |
|---|---|
| Protein Names | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 |
| Gene Symbol | RPN1 |
| Organism | Homo sapiens (Human) |
| Length | 435 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MRVKLASRNV11ESYTKLGNPT21RSEDLLDYGP31FRDVPAYSQD41TFKVHYENNS
51-10051PFLTITSMTR61VIEVSHWGNI71AVEENVDLKH81TGAVLKGPFS91RYDYQRQPDS
101-150101GISSIRSFKT111ILPAAAQDVY121YRDEIGNVST131SHLLILDDSV141EMEIRPRFPL
151-200151FGGWKTHYIV161GYNLPSYEYL171YNLGDQYALK181MRFVDHVFDE191QVIDSLTVKI
201-250201ILPEGAKNIE211IDSPYEISRA221PDELHYTYLD231TFGRPVIVAY241KKNLVEQHIQ
251-300251DIVVHYTFNK261VLMLQEPLLV271VAAFYILFFT281VIIYVRLDFS291ITKDPAAEAR
301-350301MKVACITEQV311LTLVNKRIGL321YRHFDETVNR331YKQSRDISTL341NSGKKSLETE
351-400351HKALTSEIAL361LQSRLKTEGS371DLCDRVSEMQ381KLDAQVKELV391LKSAVEAERL
401-435401VAGKLKKDTY411IENEKLISGK421RQELVTKIDH431ILDAL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 305 | SWISSPALM DBPTM CYSMODDB | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.85
Deep-Palm: 0.97
|
| 373 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.79
Deep-Palm: 0.98
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
3
LNCaP
Specificity: 0.500
3/3 (100.0%)
3
PC3
Specificity: 0.500
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 101 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 263 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 406 | R → C | 0.001969 | SNP | Missense Mutation | LGG |