Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| B7ZKQ9 | SCARB1 | Scavenger receptor class B member … | Homo sapiens (Human) | 481 aa |
Protein Details: B7ZKQ9 (SCARB1)
Protein Information
| Accession | B7ZKQ9 |
|---|---|
| Protein Names | Scavenger receptor class B member 1 (SR-BI) |
| Gene Symbol | SCARB1 |
| Organism | Homo sapiens (Human) |
| Length | 481 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19801377 31251020 31382980 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGCSAKARWA11AGALGVAGLL21CAVLGAVMIV31MVPSLIKQQV41LKNVRIDPSS
51-10051LSFNMWKEIP61IPFYLSVYFF71DVMNPSEILK81GEKPQVRERG91PYVYREFRHK
101-150101SNITFNNNDT111VSFLEYRTFQ121FQPSKSHGSE131SDYIVMPNIL141VLGAAVMMEN
151-200151KPMTLKLIMT161LAFTTLGERA171FMNRTVGEIM181WGYKDPLVNL191INKYFPGMFP
201-250201FKDKFGLFAE211LNNSDSGLFT221VFTGVQNISR231IHLVDKWNGL241SKVDFWHSDQ
251-300251CNMINGTSGQ261MWPPFMTPES271SLEFYSPEAC281RSMKLMYKES291GVFEGIPTYR
301-350301FVAPKTLFAN311GSIYPPNEGF321CPCLESGIQN331VSTCRFSAPL341FLSHPHFLNA
351-400351DPVLAEAVTG361LHPNQEAHSL371FLDIHPVTGI381PMNCSVKLQL391SLYMKSVAGI
401-450401GQTGKIEPVV411LPLLWFAESG421AMEGETLHTF431YTQLVLMPKE441KCYLFWSSSK
451-481451KGSKDKEAIQ461AYSESLMTSA471PKGSVLQEAK481L
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 3 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.08
|
| 21 | - | - | - |
Deep-Palm: 0.98
|
|
| 251 | - | - | - |
Deep-Palm: 0.03
|
|
| 280 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.78
|
|
| 321 | - | - | - |
Deep-Palm: 0.18
|
|
| 323 | - | - | - |
Deep-Palm: 0.31
|
|
| 334 | - | - | - |
GPS-Palm: 0.65
Deep-Palm: 0.41
|
|
| 384 | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.94
|
|
| 442 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.79
Deep-Palm: 0.59
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.400
4
LNCaP
Specificity: 0.364
4/4 (100.0%)
4
PC3
Specificity: 0.364
4/4 (100.0%)
1
U937 cell
Specificity: 0.091
1/1 (100.0%)
1
DU145 cell
Specificity: 0.091
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.091
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 45 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 45 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 246 | W → C | 0.002288 | SNP | Missense Mutation | STAD |
| 300 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 323 | C → C | 0.002506 | SNP | Silent | COAD |
| 453 | C → F | 0.002033 | SNP | Missense Mutation | LUSC |
| 462 | C → Y | 0.008130 | SNP | Missense Mutation | THYM |