Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| B8XPJ7 | COMT | Catechol O-methyltransferase (EC 2.1.1.6) | Homo sapiens (Human) | 221 aa |
Protein Details: B8XPJ7 (COMT)
Protein Information
| Accession | B8XPJ7 |
|---|---|
| Protein Names | Catechol O-methyltransferase (EC 2.1.1.6) |
| Gene Symbol | COMT |
| Organism | Homo sapiens (Human) |
| Length | 221 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19801377 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGDTKEQRIL11NHVLQHAEPG21NAQSVLEAID31TYCEQKEWAM41NVGDKKGKIV
51-10051GAVIQEHQPF61VLLELGAYCG71YSAVRMARLL81SPGARLITIE91INPDCAAITQ
101-150101RMVDFAGVKD111KVTLVVGASQ121DIIPQLKKKY131DVDTLDMVFL141DHWKDRYLPD
151-200151TLLLEECGLL161RRGTVLLADN171VICPGAPDFL181AHVRGSSCFE191CTHYQSFLEY
201-221201REVVDGLEKA211IYKGPGSEAG221P
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 33 | S-adenosyl-L-methionine-dependent methyltransferase superfamily CATECHOL O-METHYLTRANSFERASE 1-RELATED | - |
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.77
|
|
| 69 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.97
|
|
| 95 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.83
Deep-Palm: 0.97
|
|
| 157 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.90
Deep-Palm: 0.98
|
|
| 173 | - | - |
LNCaP
(31251020)
Unknown
(32651440)
|
GPS-Palm: 0.82
Deep-Palm: 0.98
|
|
| 188 | - | - | - |
Deep-Palm: 0.26
|
|
| 191 | - | - | - |
Deep-Palm: 0.24
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
DU145 cell
Specificity: 0.500
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.500
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 82 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |
| 234 | R → C | 0.002288 | SNP | Missense Mutation | STAD |