Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| C9J841 | CLDN12 | Claudin 12 | Homo sapiens (Human) | 175 aa |
Protein Details: C9J841 (CLDN12)
Protein Information
| Accession | C9J841 |
|---|---|
| Protein Names | Claudin 12 |
| Gene Symbol | CLDN12 |
| Organism | Homo sapiens (Human) |
| Length | 175 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGCRDVHAAT11VLSFLCGIAS21VAGLFAGTLL31PNWRKLRLIT41FNRNEKNLTV
51-10051YTGLWVKCAR61YDGSSDCLMY71DTTWYSSVDQ81LDLRVLQFAL91PLSMLIAMGA
101-150101LLLCLIGMCN111TAFRSSVPNI121KLAKCLVNSA131GCHLVAGLLF141FLAGTVSLSP
151-175151SIWVIFYNIH161LNKKFEPVFS171FDYAV
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 3 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.02
|
|
| 16 | Claudin-12 | - | - |
Deep-Palm: 0.87
|
|
| 58 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.34
|
|
| 67 | - | - | - |
Deep-Palm: 0.10
|
|
| 104 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.92
|
|
| 109 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.91
|
|
| 125 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.94
|
| 132 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.94
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
3
LNCaP
Specificity: 0.500
3/3 (100.0%)
3
PC3
Specificity: 0.500
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 151 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |