Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| C9J8Q5 | ALDH5A1 | Succinate-semialdehyde dehydrogenase (EC 1.2.1.24) | Homo sapiens (Human) | 507 aa |
Protein Details: C9J8Q5 (ALDH5A1)
Protein Information
| Accession | C9J8Q5 |
|---|---|
| Protein Names | Succinate-semialdehyde dehydrogenase (EC 1.2.1.24) |
| Gene Symbol | ALDH5A1 |
| Organism | Homo sapiens (Human) |
| Length | 507 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MATCIWLRSC11GARRLGSTFP21GCRLRPRAGG31LVPASGPAPG41PAQLRCYAGR
51-10051LAGLSAALLR61TDSFVGGRWL71PAAATFPVQD81PASGAALGMV91ADCGVREARA
101-150101AVRAAYEAFC111RWREVSAKGK121PLKEAHGEIL131YSAFFLEWFS141EEARRVYGDI
151-200151IHTPAKDRRA161LVLKQPIGVA171AVITPWNFPS181AMITRKVGAA191LAAGCTVVVK
201-250201PAEDTPFSAL211ALAELASQAG221IPSGVYNVIP231CSRKNAKEVG241EAICTDPLVS
251-300251KISFTGSTTT261GKILLHHAAN271SVKRVSMELG281GLAPFIVFDS291ANVDQAVAGA
301-350301MASKFRNTGQ311TCVCSNQFLV321QRGIHDAFVK331AFAEAMKKNL341RVGNGFEEGT
351-400351TQGPLINEKA361VEKVEKQVND371AVSKGATVVT381GGKRHQLGKN391FFEPTLLCNV
401-450401TQDMLCTHEE411TFGPLAPVIK421FDTEEEAIAI431ANAADVGLAG441YFYSQDPAQI
451-500451WRVAEQLEVG461MVGVNEGLIS471SVECPFGGVK481QSGLGREGSK491YGIDEYLELK
501-507501YVCYGGL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 4 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.03
|
| 10 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.07
|
|
| 22 | - | - | - |
GPS-Palm: 0.98
Deep-Palm: 0.98
|
|
| 46 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.98
|
|
| 93 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.98
|
|
| 110 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.90
Deep-Palm: 0.98
|
|
| 195 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.97
|
|
| 231 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.90
|
|
| 244 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.91
Deep-Palm: 0.94
|
|
| 312 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.77
|
|
| 314 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.81
Deep-Palm: 0.58
|
|
| 398 | - | - | - |
Deep-Palm: 0.74
|
|
| 406 | - | - | - |
Deep-Palm: 0.91
|
|
| 474 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.83
Deep-Palm: 0.95
|
|
| 503 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.96
Deep-Palm: 0.02
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
4
LNCaP
Specificity: 0.333
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.333
4/4 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.333
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 340 | C → Ifs*9 | 0.027027 | DEL | Frame Shift Del | DLBC |