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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
C9JDL2 TUBA4A Tubulin alpha 4a Homo sapiens (Human) 119 aa

Protein Details: C9JDL2 (TUBA4A)

Protein Information
AccessionC9JDL2
Protein NamesTubulin alpha 4a
Gene SymbolTUBA4A
OrganismHomo sapiens (Human)
Length119 aa
IsoformsNo isoforms
Related PMIDs 31251020 32944167 36430497
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MKVRECISVH11VGQAGVQMGN21ACWELYCLEH31GIQPDGQMPS41DKTIGGGDDS
51-10051FTTFFCETGA61GKHVPRAVFV71DLEPTVIDEI81RNGPYRQLFH91PEQLITGKED
101-119101AANNYARGHY111TIGKEIIDP
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
6 Tubulin/FtsZ, GTPase domain superfamily - -
GPS-Palm: 0.91
Deep-Palm: 0.02
22 Tubulin/FtsZ, GTPase domain OS01G0282866 PROTEIN Tubulin/FtsZ, GTPase domain superfamily - -
Deep-Palm: 0.32
27 Tubulin/FtsZ, GTPase domain superfamily Tubulin/FtsZ, GTPase domain OS01G0282866 PROTEIN Alpha tubulin - -
Deep-Palm: 0.14
56 SWISSPALM DBPTM CYSMODDB - -
cerebral cortex (36430497)
Deep-Palm: 0.89
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
cerebral cortex
Specificity: 0.571
4/4 (100.0%)
2
LNCaP
Specificity: 0.286
2/2 (100.0%)
1
PC3
Specificity: 0.143
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
108 Y → C 0.002545 SNP Missense Mutation GBM
123 R → C 0.001887 SNP Missense Mutation UCEC
158 S → C 0.001014 SNP Missense Mutation BRCA
210 Y → C 0.002506 SNP Missense Mutation COAD
221 R → C 0.003774 SNP Missense Mutation UCEC
229 R → C 0.005660 SNP Missense Mutation UCEC
243 R → C 0.002288 SNP Missense Mutation STAD
243 R → C 0.001887 SNP Missense Mutation UCEC
277 S → C 0.002427 SNP Missense Mutation BLCA
339 R → C 0.001887 SNP Missense Mutation UCEC
350 G → C 0.001887 SNP Missense Mutation UCEC