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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
C9JE06 PLSCR1 Phospholipid scramblase Homo sapiens (Human) 249 aa

Protein Details: C9JE06 (PLSCR1)

Protein Information
AccessionC9JE06
Protein NamesPhospholipid scramblase
Gene SymbolPLSCR1
OrganismHomo sapiens (Human)
Length249 aa
IsoformsNo isoforms
Related PMIDs 19801377 29575903 32651440 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MDKQNSQMNA11SHPETNLPVG21YPPQYPPTAF31QGPPGYSGYP41GPQVSYPPPP
51-10051AGHSGPGPAG61FPVPNQPVYN71QPVYNQPVGA81AGVPWMPAPQ91PPLNCPPGLE
101-150101YLSQIDQILI111HQQIELLEVL121TGFETNNKYE131IKNSFGQRVY141FAAEDTDCCT
151-200151RNCCGPSRPF161TLRIIDNMGQ171EVITLERPLR181CSSCCCPCCL191QEIEIQAPPG
201-249201VPIGYVIQTW211HPCLPKFTIQ221NEKREDVLKI231SGPCVVCSCC241GDVDFEIKS
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
95 - - -
Deep-Palm: 0.77
148 SWISSPALM DBPTM CYSMODDB Scramblase
HeLa (29575903)
cerebral cortex (36430497)
GPS-Palm: 0.91
Deep-Palm: 0.66
149 SWISSPALM DBPTM CYSMODDB Scramblase
HeLa (29575903)
cerebral cortex (36430497)
GPS-Palm: 0.92
Deep-Palm: 0.80
153 SWISSPALM DBPTM CYSMODDB Scramblase
HeLa (29575903)
-
GPS-Palm: 0.81
Deep-Palm: 0.08
154 SWISSPALM DBPTM CYSMODDB Scramblase
HeLa (29575903)
-
GPS-Palm: 0.86
Deep-Palm: 0.17
181 - - -
GPS-Palm: 0.91
Deep-Palm: 0.78
184 - - -
GPS-Palm: 0.96
Deep-Palm: 0.46
185 - - -
GPS-Palm: 0.96
Deep-Palm: 0.44
186 - - -
GPS-Palm: 0.96
Deep-Palm: 0.45
188 - - -
GPS-Palm: 0.96
Deep-Palm: 0.63
189 - - -
GPS-Palm: 0.92
Deep-Palm: 0.78
213 SWISSPALM DBPTM CYSMODDB Scramblase
HeLa (29575903)
-
GPS-Palm: 0.85
Deep-Palm: 0.83
234 -
HeLa (29575903)
-
Deep-Palm: 0.43
237 -
HeLa (29575903)
-
Deep-Palm: 0.16
239 -
HeLa (29575903)
-
GPS-Palm: 0.69
Deep-Palm: 0.03
240 -
HeLa (29575903)
-
Deep-Palm: 0.03
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.364
4
PC3
Specificity: 0.267
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.267
4/4 (100.0%)
1
HeLa cell
Specificity: 0.067
1/1 (100.0%)
1
Jurkat T cell
Specificity: 0.067
1/1 (100.0%)
1
DU145 cell
Specificity: 0.067
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.267
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
21 Y → C 0.002288 SNP Missense Mutation STAD
55 G → C 0.001764 SNP Missense Mutation LUAD
134 S → delinsILNC 0.001887 INS In Frame Ins UCEC
169 G → C 0.002033 SNP Missense Mutation LUSC
181 C → Y 0.002545 SNP Missense Mutation GBM
188 C → C 0.002294 SNP Silent OV
210 W → C 0.002033 SNP Missense Mutation LUSC
213 C → Y 0.001764 SNP Missense Mutation LUAD
254 C → Y 0.002506 SNP Missense Mutation COAD