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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
C9JEV8 TUBA4A Tubulin alpha chain Homo sapiens (Human) 153 aa

Protein Details: C9JEV8 (TUBA4A)

Protein Information
AccessionC9JEV8
Protein NamesTubulin alpha chain
Gene SymbolTUBA4A
OrganismHomo sapiens (Human)
Length153 aa
IsoformsNo isoforms
Related PMIDs 31251020 36430497
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MGNACWELYC11LEHGIQPDGQ21MPSDKTIGGG31DDSFTTFFCE41TGAGKHVPRA
51-10051VFVDLEPTVI61DEIRNGPYRQ71LFHPEQLITG81KEDAANNYAR91GHYTIGKEII
101-150101DPVLDRIRKL111SDQCTGLQGF121LVFHSFGGGT131GSGFTSLLME141RLSVDYGKKS
151-153151KLE
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
5 Tubulin/FtsZ, GTPase domain superfamily - -
GPS-Palm: 0.87
Deep-Palm: 0.02
10 Tubulin/FtsZ, GTPase domain superfamily Alpha tubulin - -
Deep-Palm: 0.02
39 SWISSPALM DBPTM CYSMODDB Tubulin/FtsZ, GTPase domain superfamily Tubulin -
cerebral cortex (36430497)
Deep-Palm: 0.89
114 - - -
Deep-Palm: 0.71
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
4
cerebral cortex
Specificity: 0.667
4/4 (100.0%)
2
LNCaP
Specificity: 0.333
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
108 Y → C 0.002545 SNP Missense Mutation GBM
123 R → C 0.001887 SNP Missense Mutation UCEC
158 S → C 0.001014 SNP Missense Mutation BRCA
210 Y → C 0.002506 SNP Missense Mutation COAD
221 R → C 0.003774 SNP Missense Mutation UCEC
229 R → C 0.005660 SNP Missense Mutation UCEC
243 R → C 0.002288 SNP Missense Mutation STAD
243 R → C 0.001887 SNP Missense Mutation UCEC
277 S → C 0.002427 SNP Missense Mutation BLCA
339 R → C 0.001887 SNP Missense Mutation UCEC
350 G → C 0.001887 SNP Missense Mutation UCEC