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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
C9JNR4 RHOA Transforming protein RhoA Homo sapiens (Human) 138 aa

Protein Details: C9JNR4 (RHOA)

Protein Information
AccessionC9JNR4
Protein NamesTransforming protein RhoA
Gene SymbolRHOA
OrganismHomo sapiens (Human)
Length138 aa
IsoformsNo isoforms
Related PMIDs 19801377 26876311 31251020 36430497
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MAAIRKKLVI11VGDGACGKTC21LLIVFSKDQF31PEVYVPTVFE41NYVADIEVDG
51-10051KQVELALWDT61AGQEDYDRLR71PLSYPDTDVI81LMCFSIDSPD91SLENIPEKWT
101-138101PEVKHFCPNV111PIILVGNKKD121LRNDEHTRRE131LAKMKQEP
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
16 SWISSPALM DBPTM CYSMODDB Ras family P-loop containing nucleoside triphosphate hydrolase Transforming protein P21 ras signature Small GTPase Small GTPase Rho -
cerebral cortex (36430497)
GPS-Palm: 0.89
Deep-Palm: 0.98
20 P-loop containing nucleoside triphosphate hydrolase Transforming protein P21 ras signature Small GTPase Small GTPase Rho -
Unknown (32651440)
cerebral cortex (36430497)
GPS-Palm: 0.75
Deep-Palm: 0.97
83 - - -
Deep-Palm: 0.81
107 SWISSPALM DBPTM CYSMODDB Ras family -
Unknown (32651440)
cerebral cortex (36430497)
Deep-Palm: 0.97
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.333
2
LNCaP
Specificity: 0.333
2/2 (100.0%)
2
cerebral cortex
Specificity: 0.333
2/2 (100.0%)
1
frontal cortex
Specificity: 0.167
1/1 (100.0%)
1
DU145 cell
Specificity: 0.167
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
16 C → S 0.007299 SNP Missense Mutation READ
20 C → G 0.002427 SNP Missense Mutation BLCA
34 Y → C 0.004577 SNP Missense Mutation STAD
34 Y → C 0.005435 SNP Missense Mutation ESCA
39 F → C 0.002288 SNP Missense Mutation STAD
42 Y → C 0.006865 SNP Missense Mutation STAD
68 R → C 0.002545 SNP Missense Mutation GBM
107 C → C 0.001887 SNP Silent UCEC
152 G → C 0.002294 SNP Missense Mutation OV
154 F → C 0.007299 SNP Missense Mutation READ
183 R → C 0.001887 SNP Missense Mutation UCEC