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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
C9JX21 RHOA Ras homolog family member A Homo sapiens (Human) 187 aa

Protein Details: C9JX21 (RHOA)

Protein Information
AccessionC9JX21
Protein NamesRas homolog family member A
Gene SymbolRHOA
OrganismHomo sapiens (Human)
Length187 aa
IsoformsNo isoforms
Related PMIDs 26876311 31251020 32944167 36430497
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MAAIRKKLVI11VGDGACGKTC21LLIVFSKDQF31PEVYVPTVFE41NYVADIEVDG
51-10051KQVELALWDT61AGQEDYDRLR71PLSYPDTDVI81LMCFSIDSPD91SLENIPEKWT
101-150101PEVKHFCPNV111PIILVGNKKD121LRNDEHTRRE131LAKMKQEPHC141VARLECCGTI
151-187151LAQLQPPPPR161FKRFPCLSLL171SSWGYRRPLP181HPGAGET
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
16 SWISSPALM DBPTM CYSMODDB Ras family P-loop containing nucleoside triphosphate hydrolase Transforming protein P21 ras signature Small GTPase Small GTPase Rho -
cerebral cortex (36430497)
GPS-Palm: 0.89
Deep-Palm: 0.98
20 P-loop containing nucleoside triphosphate hydrolase Transforming protein P21 ras signature Small GTPase Small GTPase Rho -
Unknown (32651440)
cerebral cortex (36430497)
GPS-Palm: 0.75
Deep-Palm: 0.97
83 - - -
Deep-Palm: 0.81
107 SWISSPALM DBPTM CYSMODDB Ras family -
Unknown (32651440)
cerebral cortex (36430497)
Deep-Palm: 0.97
140 - - -
GPS-Palm: 0.77
Deep-Palm: 0.87
146 - - -
GPS-Palm: 0.66
Deep-Palm: 0.90
147 - - -
GPS-Palm: 0.81
Deep-Palm: 0.85
166 - - -
GPS-Palm: 0.89
Deep-Palm: 0.97
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.375
3
PC3
Specificity: 0.375
3/3 (100.0%)
2
LNCaP
Specificity: 0.250
2/2 (100.0%)
2
cerebral cortex
Specificity: 0.250
2/2 (100.0%)
1
frontal cortex
Specificity: 0.125
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
16 C → S 0.007299 SNP Missense Mutation READ
20 C → G 0.002427 SNP Missense Mutation BLCA
34 Y → C 0.004577 SNP Missense Mutation STAD
34 Y → C 0.005435 SNP Missense Mutation ESCA
39 F → C 0.002288 SNP Missense Mutation STAD
42 Y → C 0.006865 SNP Missense Mutation STAD
68 R → C 0.002545 SNP Missense Mutation GBM
107 C → C 0.001887 SNP Silent UCEC
152 G → C 0.002294 SNP Missense Mutation OV
154 F → C 0.007299 SNP Missense Mutation READ
183 R → C 0.001887 SNP Missense Mutation UCEC