Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| D6RF62 | PAICS | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase … | Homo sapiens (Human) | 333 aa |
Protein Details: D6RF62 (PAICS)
Protein Information
| Accession | D6RF62 |
|---|---|
| Protein Names | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase, isoform CRA_b) |
| Gene Symbol | PAICS |
| Organism | Homo sapiens (Human) |
| Length | 333 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MIPIEWVCRR11IATGSFLKRN21PGVKEGYKFY31PPKVELFFKD41DANNDPQWSE
51-10051EQLIAAKFCF61AGLLIGQTEV71DIMSHATQAI81FEILEKSWLP91QNCTLVDMKI
101-150101EFGVDVTTKE111IVLADVIDND121SWRLWPSGDR131SQQKDKQSYR141DLKEVTPEGL
151-200151QMVKKNFEWV161AERVELLLKS171ESQCRVVVLM181GSTSDLGHCE191KIKKACGNFG
201-250201IPCELRVTSA211HKGPDETLRI221KAEYEGDGIP231TVFVAVAGRS241NGLGPVMSGN
251-300251TAYPVISCPP261LTPDWGVQDV271WSSLRLPSGL281GCSTVLSPEG291SAQFAAQIFG
301-333301LSNHLVWSKL311RASILNTWIS321LKQADKKIRE331CNL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 8 | SAICAR synthase-like SAICAR synthetase/ADE2, N-terminal SAICAR synthetase, conserved site SAICAR synthetase | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.02
|
|
| 59 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.56
|
|
| 93 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.53
|
|
| 174 | - | - | - |
Deep-Palm: 0.96
|
|
| 189 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.88
Deep-Palm: 0.87
|
|
| 196 | DBPTM SWISSPALM | AIR carboxylase | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.93
|
| 203 | SWISSPALM DBPTM CYSMODDB | AIR carboxylase | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.96
|
| 258 | - | - | - |
Deep-Palm: 0.48
|
|
| 282 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.88
Deep-Palm: 0.97
|
|
| 331 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.03
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
4
cerebral cortex
Specificity: 0.333
4/4 (100.0%)
3
PC3
Specificity: 0.250
3/3 (100.0%)
1
LNCaP
Specificity: 0.083
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.333
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 14 | Y → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 185 | C → C | 0.001887 | SNP | Silent | UCEC |